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Biomedical subjects

J Giese

Publications and source records attributed to J Giese.

At least 127 records · Page 7Linked to original sources
PubMed1975

[131I]Hippuran renography in normal subjects and in patients with essential hypertension.

Seventeen normal subjects and 21 patients with essential hypertension were examined by [131I]hippuran renography. Both groups were studied twice on the same day, first in a state of moderate dehydration and then after rehydration. From these data, four sets of reference intervals were established for several renographic parameters. Differences between the two groups were defined. The most impressive observation was a greater functional disparity between the two kidneys of one individual in the group of hypertensive patients, particularly when in a state of moderate volume depletion. This was reflected in a greater variance of certain kidney-to-kidney ratios derived from the renographic tracings. This article presents basic data to be utilized in clinical renography, as described in an accompanying article.

Adult↗
PubMed1975

Diagnostic value of renography for detection of unilateral renal or renovascular disease in hypertensive patients.

In an effort to find an optimal set of renographic reference parameters for the study of hypertensive patients, the renographic data from 50 hypertensive patients with unilateral renal or renovascular disease were assessed against 95% confidence intervals obtained in normal subjects and in patients with essential hypertension in two different states of hydration. The highest all-over nosographic sensitivity and specificity were obtained by using the data from hydrated normal subjects as reference parameters. The nosographic sensitivity and specificity found in the selected series of hypertensive patients were converted to the clinically relevant predictive values of a positive and a negative test by assuming the prevalence of unilateral renal or renovascular disease in hospital populations of hypertensive patients to be 5% or 10%. In these model populations the predictive value of a postive was 33% and 51%, respectively. The predictive value of a negative test was higher than 99% for both populations. We find that predictive values of that order of magnitude are satisfactory for a test to be used in the initial phase of a diagnostic process.

Dehydration↗