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Biomedical subjects

J Germouty

Publications and source records attributed to J Germouty.

At least 37 records · Page 2Linked to original sources
PubMed1986

Double-blind comparison of tulobuterol and salbutamol in chronic obstructive pulmonary disease.

A double-blind study compared tulobuterol (2 mg BID), a new beta 2-adrenergic agent, with salbutamol (2 mg TID) in 40 hospitalized men with chronic obstructive pulmonary disease. The study evaluated the bronchospasmolytic effects of the two drugs and their selectivity of action. Measurements and observations were made for six hours after the first oral dose, daily during nine days of continuous therapy, and for 12 hours after the final dose on the tenth day. Results show that the tulobuterol regimen produced a significant (P less than 0.01) improvement of the forced expiratory volume in one second equal to an increase of 25% above the pretreatment value, versus 16% with the salbutamol regimen. Cardiovascular effects appeared more rapidly with tulobuterol, but they stabilized to values lower than those observed with salbutamol. No clinically important adverse reactions were reported other than slight tremor, which was not objectionable.

Adrenergic beta-Agonists↗
PubMed1986

[Skin tests in the exploration of perianesthetic complications].

Adverse reactions in anesthesia are more and more frequent. The favoring factors are multiple but the physiopathology of these reactions are not right known: non specific histamine-release, complement activation is anaphylaxis can occur. Skin tests are an very important data for the diagnosis of these accidents. Forty patients and ten healthy subjects were tested with systematic research of a cross-reactivity for curare family; myorelaxants, fluid gelatin, dextran are the tests the most frequently positive. Cross reactivity for curare family is sure and sensibilization by some medicine is possible. Then the behavior of the data is looked at; the research of the favoring factors, the non utilization of some substances and prophylactic treatment are recommended.

Anesthetics↗
PubMed1986

[Immunotherapy of recurrent respiratory infections. Double-blind study of a new immunomodulator in 60 patients].

A new immunomodulator, SLO4 oral drops, was tested for treatment and prevention of recurrent respiratory infections in a double-blind, drug versus placebo trial conducted in 60 adults with chronic bronchitis or asthma. This agent brought about a highly significant reduction in the frequency and duration of infectious episodes, as well as a decrease in antibiotic consumption and lost work time. Well tolerated from the clinical and laboratory points of view, it proved remarkably effective. It has been hypothesized that induction of interferon may account for the excellent clinical results obtained with SLO4, and numerous authors regard this compound as one of the basic keys to regulation of immune reactivity. Pharmacological trials under way with SLO4 should help answer this question.

Adjuvants, Immunologic↗
PubMed1985

[Bronchopulmonary hamartochondroma (apropos of 136 cases, including a homogeneous series of 124 cases). Review of the literature].

On the basis of a series of 136 hamartochondromas, the largest ever published, the authors review the clinical and paraclinical characteristics of bronchopulmonary hamartochondromas. After describing their pathological study, particular attention is paid to the controversial pathogenesis of these tumors before dealing with therapeutic aspects. Review of the literature.

Adolescent↗
PubMed1983

[Secondary cancer of the bronchi. General review apropos of 3 cases].

The authors report 3 cases of endobronchial metastases of visceral carcinomas (kidney, breast, pancreas). With the aid of a review of the 144 cases found in the literature, they analyse the characteristics of this special type of secondary neoplasm and their diagnostic, physiopathological and therapeutic aspects.

Aged↗
PubMed1980

[Multicenter, double-blind study of oral acetylcysteine vs. placebo].

The mucolytic activity of acetylcysteine (NAC) was evaluated in a double-blind, placebo controlled, clinical trial performed in three pneumology centres and involving a total of 215 patients with the following diagnoses: 84 acute bronchitis, 95 superinfections of chronic bronchitis, 36 complicated bronchitis in patients with severe chronic respiratory insufficiency. Treatment consisted of 1 sachet of 200 mg NAC t.i.d. for 10 days. Standard antibiotic therapy (amoxycillin 1.5 g/day) was concurrently administered for 7 days. Statistical analysis comparing sputum volume and viscosity, sedation of cough and improvement of PEFR in 108 NAC and in 107 placebo treated patients, showed that NAC was very significantly more effective than placebo. The effect of NAC was negligible in the 36 patients with complicated bronchitis, whereas it was evident and remarkable in patients with acute and chronic bronchitis.

Acetylcysteine↗
PubMed1978

[Value of bronchopulmonary fibro-lavage in the treatment of severe suppurative pneumopathies].

The therapeutical use of bronchial fibroscopy is very promising. Already today it is much used in postsurgery atelectasies by obstruction or in suppurative atelectasies related to important infectious foci. It considerably improves the bronchial clearing previously done by blind aspiration or bronchoscopy. The coupling of this aspiration to a perfusion-lavage in severe suppurative bacterial pneumopathies yielded interesting results.

Acute Disease↗
PubMed1976

[Capillary sample and blood gas analysis. Technic and validity].

The authors have developed a technique of sampling and analysis of capillary blood which they describe here. Applied to 34 patients, it gives excellent correlations, both for PO2-PCO2 and pH. The advantages of capillary methods and their disadvantages are discussed.

Arteries↗
PubMed1976

[Benign tumors of the pleura].

The authors report a case of benign tumour of the pleura in a 74 year old woman. This is a pediculated tumour of the right base posteriorly above the diaphragm, the pleural nature of which was recognised before surgery and which, microscopically, proved to be a localized, benign mesothelioma of fibroblastic type. Benigh tumours of the pleura are rare but raise two interesting problems: that of their precise origin which is debated, and their prognosis; the possibility of relapse should be borne in mind.

Aged↗
PubMed1976

[Pulmonary metastasis from Vater's ampullomas].

The authors report two cases of carcinoma of the ampulla of Vater with numerous pulmonary metastases. This carcinoma is a malignant tumour with a very poor short-term prognosis. This tumour develops at the expense of the ampulla of Vater and may give rise to numerous pulmonary metastases and carcinomato,s lymphangitis. Authors are not unanimous concerning the course and prognosis of these tumours. In fact, one may note two tendencies, one optimistic, which seems to us erroneous, the other pessimistic, which we share.

Adenocarcinoma↗
PubMed1976

[Validity of bronchial flow measurement by Wright's air flowmeter. Comparison with maximal expiratory volume in a second].

The validity of measurement of bronchial air flow, using Wright's air flow meter, was studied comparing the maximum air flow thus obtained with the maximum expiratory volume in one second, used as unit of reference. During a first stage, the reproducibility of the test was determined this was excellent, 3.26% for the maximal flow rate and 2.48% for the maximum volume expired in one second. During a second stage were drawn up correlations between the two tests which were very narrow: O.971 in healthy sbjects, 0.919 in sick patients. The Wright flow meter is a strong, reliable and inexpensive instrument and will thus be very useful in the daily assessment of bronchiolar constriction at the bed side, and in the routine detection of obstructive syndromes.

Adult↗