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J George

Publications and source records attributed to J George.

At least 289 records · Page 16Linked to original sources
PubMed1986

[The use of microcrystalline cellulose dispersions for the production of dermatologic agents].

The employment oft microcrystalline cellulose of the Heweten-type (cellulose powder(AB-GDR) for the production of dermatological preparations as aqueous and aqueous-oily multicomponent systems can contribute to the opening of a further field of application of this auxiliary substance in pharmaceutical factories and pharmacies. By means of intensive shearing and mixing forces, e.g. a colloid mill, it is possible to produce dispersions with fluid media, which proved to be stable when they contained a solid content over 8 p.c. Such dispersions can improve the utilization properties of various preparations. By varying the solid content concentration one can produce dispersions of different properties. Microcrystalline cellulose powders meet the demands which characterize an auxiliary substance in general. Special attention has to be drawn on the problem of microbiological stability because of the necessarily high moisture content of the dispersion. Preparations manufactured by colloid wet grinding with microcrystalline cellulose are distinguished by a high physicochemical stability.

Cellulose↗
PubMed1985

Sequence-specific BamHI endonuclease. The proposed role of arginine residues in substrate binding and recognition.

Arginyl residues in BamHI endonuclease were examined because of their alleged role in proteins that contain nucleotide- or phosphate-binding sites. Butanedione, an arginine-specific reagent, inhibited the endonuclease in the presence of sodium borate. The inhibition was decreased by preliminary incubation of the enzyme with DNA or competitive inhibitors which were the 5'-phosphoryl deoxydinucleotide subsets of the BamHI recognition sequence. The dinucleotide pdGpdG protected the enzyme most efficiently against the butanedione modification. Dinucleotides that were unrelated to the recognition sequence failed to protect the enzyme from inactivation. These studies indicate that arginine residues may reside in the enzyme's active site and might function in the sequence-specific recognition of the BamHI palindrome.

Arginine↗
PubMed1985

Self-biting with multiple finger amputations following spinal cord injury.

We have observed mutilative self-biting leading to multiple finger amputations in two patients following C4 complete spinal cord injury (SCI). Both men were of normal intelligence without psychosis and each had a neurotic personality and history of fingernail biting. They related the self-biting to anxiety and depression. We believe these to be the first English language reports of multiple finger amputations due to self-biting following SCI.

Adult↗
PubMed1985

Enhanced luminescence enzyme immunoassay for factor VIII related antigen.

A sandwich enzyme immunoassay for plasma factor VIII related antigen has been developed which exploits a para-iodophenol enhanced chemiluminescent reaction to detect the horseradish peroxidase label. The assay entailed 15 min incubations with sample and with conjugate and had a detection limit of 0.12 mU. It showed good within batch precision (coefficient of variation = 2.95-5.8%) and results on a series of 57 specimens agreed with results obtained by immunoelectrophoresis (correlation coefficient = 0.97).

Antigens↗
PubMed1984

Democracy rules.

Explore the source record for details and available documents.

Democracy↗
PubMed1984

Sequence-specific BamHI methylase. Purification and characterization.

BamHI methylase has been purified to apparent homogeneity. The isolated form of the enzyme is a single polypeptide with a molecular weight of 56,000 as determined by sodium dodecyl sulfate-polyacrylamide electrophoresis. Unlike BamHI endonuclease, which is isolated as a dimer and higher aggregates, the methylase has no apparent higher form. The methylase requires S-adenosyl-L-methionine as the methyl-group donor and is inhibited by Mg2+. The enzyme is also inhibited by 2,3-butanedione and reagents specific for sulfhydryl groups, such as N-ethylmaleimide, which suggests a role for arginine and cysteine residues, respectively. DNA efficiently protects the enzyme against the butanedione modification while S-adenosylmethionine has no effect. In contrast, S-adenosylmethionine protects against cysteine modification while DNA produces only small amounts of protection. Studies on the mechanism of methylation indicate that both strands of the recognition sequence are modified in a single binding event. The sequence specificity of the methylase is relaxed upon the addition of glycerol in the reaction mixture. In the presence of 30% glycerol the enzyme methylates sequences that are also recognized by BamHI endonuclease when acting under conditions of relaxed specificity.

Bacillus↗
PubMed1984

Baclofen toxicity associated with declining renal clearance after ibuprofen.

A 64-year-old male with an incomplete spinal cord injury had been taking baclofen 20 mg tid for 2 1/2 months without side effects. His blood urea nitrogen and serum creatinine rose from 13 and 0.9 mg%, respectively, to 59 and 2.8 mg% after ibuprofen 600 mg tid was begun. The patient displayed baclofen toxicity, developing confusion, disorientation, bradycardia, and hypothermia. His blood pressure dropped and he complained of blurred vision. Ibuprofen discontinuation and fluid repletion corrected the renal indices. Rapid tapering of baclofen was accompanied by reversal of baclofen toxicity. Patients taking baclofen must be monitored closely for toxicity when declining renal function is present. Clinicians should be alert to the possibility of renal insufficiency developing when ibuprofen is initiated. This case demonstrates the potential for ibuprofen-induced renal insufficiency to reduce baclofen clearance, thereby leading to baclofen toxicity. Published reports of ibuprofen-induced renal insufficiency are reviewed and pertinent pharmacokinetics of baclofen discussed.

Acute Kidney Injury↗
PubMed1984

Telogen effluvium: hair loss after spinal cord injury.

A 26-year-old man sustained a C5 complete spinal cord injury (SCI) and displayed hysteric behavior which continued into the fourth month of hospitalization. Four months after injury, sudden loss of scalp hair was noted, consistent with psychogenic telogen effluvium. Other causes of hair loss were ruled out. During the sixth month, peak hair loss was noted over the back of the head. Four months after peak shedding, the loss of young club hairs was no longer observed. Recovery was complete seven months after peak loss, leaving a smaller permanent area of diffuse hair loss over the occiput. This pattern of hair loss has not been described previously in association with SCI.

Adult↗