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Biomedical subjects

J Genest

Publications and source records attributed to J Genest.

At least 451 records · Page 25Linked to original sources
PubMed1971

A decreased metabolic clearance rate of aldosterone in benign essential hypertension.

Aldosterone secretion rate, metabolic clearance rate, and/or plasma concentration were determined in 16 patients with benign, uncomplicated essential hypertension and compared with those of control subjects. The mean metabolic clearance rate of aldosterone in 10 patients was significantly (P < 0.001) lower (mean 867 liters of plasma/day per m(2) +/-270 SD) than in a group of 7 healthy subjects (mean 1480 liters/day per m(2) +/-265 SD). Secretion rates in 13 patients (including the 10 already mentioned) tended to be low (83 +/-43 vs. 109 +/-54 mug/day) and plasma concentrations tended to be high (13.6 +/-4.6 vs. 7.5 +/-4.8 ng/100 ml), but neither of these differences was statistically significant. The lower metabolic clearance rate could account for elevated plasma concentrations of aldosterone even when the secretion rate is normal or low. Measurement of secretion rate or urinary excretion only is therefore insufficient to establish the presence and/or mode of evolution of hyperaldosteronism. Failure of the aldosterone secretion to adapt fully to a decreased aldosterone metabolic clearance rate (MCR) could explain the state of relative hyperaldosteronism in patients with benign essential hypertension, even when the secretion rate and the urinary excretion rate are in the normal range.

Adaptation, Physiological↗
PubMed1970

Autopsy study of adrenals in unselected normotensive and hypertensive patients.

The records of the Hôtel-Dieu Hospital of Montreal, a general teaching hospital, provided 2425 consecutive autopsies done between January 1, 1955 and January 1, 1965. According to the diagnostic criteria used, 44.2% of the patients were hypertensive. Adrenal adenomas, nodules or hyperplasia were found in 7% of the hypertensive patients and in only 1.9% of the normotensive ones. The most frequently encountered lesion was adenoma (4.2% in the hypertensive population and 1.1% in the normotensive one). These results constitute supportive evidence for a low incidence of "normokalemic primary aldosteronism".

Adenoma↗