Search PubMed⌕ Search

Biomedical subjects

J Geldmacher

Publications and source records attributed to J Geldmacher.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Tendon sutures with a new monofilament synthetic absorbable suture material (PDS-suture of 6-0 strength). Results of animal experiments].

The absorbable synthetic suture (PDS suture 6-0 with spatula needle) was examined by experiments on the tendon of the M. flexor digitorum pedis communis of the hare. A total of 34 tendon sutures was prepared histologically and evaluated. The new suture material is distinguished by greatly extended absorption time, low foreign body reaction and an improved tensile strength. With this suture, the conditions in which absorbable suture material can be used are increased. This is particularly true of so-called bradytrophic tissue.

Animals↗
PubMed1981

Comparison of ftorafur with 5-fluorouracil in combination chemotherapy of advanced gastrointestinal carcinoma.

The aim of the study was to compare the combination 5-FU-carmustine with ftorafur-carmustine in the treatment of advanced gastrointestinal cancer. To this end, a prospective, multicenter, randomized trial was initiated. Part I of this trial showed that similar response rates can be obtained with 5-FU-carmustine and ftorafur-carmustine in 109 patients (32.7% versus 26.3%). However, median survival was better in patients treated with 5-FU-carmustine (307 days versus 163 days). Part II of the trial revealed that neither a higher dosage of ftorafur (2 g/m2/day X 5 days) nor the addition of vincristine to both regimens changed the previously obtained results significantly. Again, median survival was found to be better in patients treated with 5-FU combination chemotherapy (304 days versus 144 days). Both the 5-FU and the ftorafur combination were tolerated reasonably well. The results suggest that combination chemotherapy including 5-FU is superior to ftorafur at the applied dosages in terms of survival.

Adult↗
PubMed1981

[Transplantation of nervus peroneus by microsurgery (author's transl)].

From 1969-1977 at the Erlangen University Surgical Clinic 15 transplantations of the nervus peroneus were performed. 10 patients could be followed up within a time of 2-5 years after operation. As to the sensibility in most cases only protective sensibility could be achieved; as to the motor function the results were likewise poorer than in the upper limb. Beside our own results those of other authors were reported. Possible causes of the relatively bad prognosis of the Nervus peroneus were shown.

Accidents↗
PubMed1981

[Reconstruction of flexor tendons of the hand (author's transl)].

In the reconstruction of lacerated flexor tendons excellent and good results could be achieved in 51%.--The best results were obtained in zone 1, 3, 4 and 7 according to Verdan's classification. Depending on the operative technique of reconstruction the best results were obtained in reinsertion and primary suture of the tendons. In free tendon grafting the two-staged procedure gave better results than the modified Paneva-Holewich-technique and this was better than the classical tendon grafting in one operation.--Dissected flexor tendons are recommended to be reconstructed primarily according to Kleinert's principles. Some special operative techniques, suture materials, and new instruments are discussed.

Finger Injuries↗
PubMed1980

[The small fragment in the finger and middle hand region].

The fixation of mini-fragments in phalangeal or metacarpal bones after exact operative reposition is often very difficult. The use of pull-out-wires or Kirschner-wires leads often to a new dislocation or the fragment breaks. Such little fragments we fix with a synthetic glue (Histoacryl). The results are good. Infections have not been observed.

Enbucrilate↗
PubMed1980

[Plastic surgery of soft tissue defects of the hand].

The primary closure of defects of the hand is mandatory. In case of exposure of deeper structures a flap procedure is necessary. Random and axial pattern flaps and also tissue transplantation with microsurgical anastomoses are demonstrated in this paper.

Amputation, Traumatic↗
PubMed1980

[Late complications of infections and their treatment].

Operations to improve function after pyogenic infections of the hand and fingers should not be planned as long as a flare up of the infection is to be feared. There sould be no disturbance of circulation, no scars of skin or subcutaneous tissue and an adequate range of passive finger joint-movement. If there is little chance of restitution, one should not hesitate to amputate.

Cellulitis↗
PubMed1979

[A prospective multi-centre study of the response of metastatic gastrointestinal tumours (author's transl)].

In a prospective, multi-centre, randomized study of 109 patients with metastatic gastro-intestinal adenocarcinomas the response rate, survival time and side-effects of two drug combinations, carmustin +5-fluorouracil and carmustin + ftorafur, were compared (same carmustin dosage in both groups). Response to the treatment was 32.7% in those receiving carmustin +5-fluorouracil, 26.3% in those on carmustin + ftorafur. This difference occurred among the 42 patients with gastric adenocarcinoma (33.3% compared with 25%), as well as in 11 with pancreatic adenocarcinoma, and in 56 with colorectal adenocarcinoma (32.1% and 28.6%). Median survival time for 5-fluorouracil + carmustin was 330 days, double that for ftorafur + carmustin (163 days). Bone-marrow toxicity (leukopenia, thrombopenia) was below 10% for both drug combinations. Alopecia occurred in only a few patients. Gastro-intestinal toxicity was common (20% and 18.5%, respectively), but there was no difference between the two groups. The somewhat lower effectiveness of ftorafur compared with 5-fluorouracil was probably due to the deliberately smaller dosage of the former.

Adenocarcinoma↗
PubMed1979

[The enlarged butterfly-flap operation].

On regard to the butterfly flap plasty of SHAW 1973, we developed a modified technique by enlarging this method. This method will deepen the interdigital fold without transplantation of skin. We have operated between 1976--1979 twenty two patients by this method with a rather good functional and aesthetic result.

Hand↗
PubMed1978

[Amputation involving the hand: indication and technique (author's transl)].

More than 3% of all work-related hand injuries result in partial or total amputation of fingers or hands (of 14621 patients with hand injuries, 479 patients had 878 amputations). When there is no possibility or indication for microsurgical replantation, the aim of the surgical effort is to rebuild a sensitive, vigorous grasp. The different procedures for plastic surgery of the hand are discussed.

Accidents, Occupational↗
PubMed1978

[Gout - a surgical problem].

The incidence of gout has increased in recent years. For effective treatment an interdisciplinary approach is necessary. Medical therapy can be effectively supported by surgical removal of the tophi. This way normalisation of the uric-acid-pool can be achieved more quickly without additional harmful effects on the kidneys. Especially in the area of the hand surgical extirpation of the tophi can be gratifying, though it may be a difficult task. Severe restrictions in function of the hand can be corrected. This is demonstrated by the case of a 56 year old patient.

Allopurinol↗
PubMed1977

[Intraosseous neurinoma].

A case of neurilemmoma in bone localized in the proximal phalanx of the right thumb is described. There are less than 40 cases of this typoe of tumor to be found in the literature. The majority of them were localized in the jaw and maxillary bones. The tumor usually grows slowly, histories of up to 20 years duration being described. Clinical symptoms are not characteristic. X-ray examination shows cystic bone defects. The origin of the neurilemmoma in bone is believed to be cells of SCHWANN of the paravasal nerves, which accompany the nutrient artery. Microscopically two types of cells can be distinguished in the tumor. The neurilemmoma in bone is probably always benign. The therapy of choice is local excision of the tumor.

Adult↗
PubMed1977

[Tumors and tumor-like lesions of the hand].

Between 1967 and 1976, 269 tumors of the hand were treated. Among the 56 epithelial tumors the malignant ones played the dominant role whereas they are seldom found in those of soft tissue and osseous skeleton. From the tumors of the hand the "tumorlike lesions" have to be separed according to the recommendations of the World Health Organisation in 1969. In the epithelium the most frequent ones are the verruca vulgaris, the verruca plana, the atheroma, the molluscum contagiosum and the mucoid epithelial cyst. In the soft tissues most common are ganglion, traumatic neuroma, nodular tenosynovitis, giant cell tumor of synovium, hygroma, foreign body granuloma and other inflammatory or metabolic alterations, as for example on the basis of degenerative arthritis or primary chronic polyarthritis. Dupuytren's contracture and keloid are also considered "tumorlike lesions" within the frame of fibromatosis. The osseous skeleton is included in the so-called solitary bone cysts.

Bone Neoplasms↗
PubMed1976

[Tenosynovitis nodosa].

Nodular tenosynovitis occurs in a localized and in a diffuse form. The histologie finding are rather variable. According to electron microscopic studies nodular tenosynovitis originates in the synovial membrane. Mainly there are two types of cells to be found in the tumor: Type A, similar to macrophages - type B, similar to fibroblasts. The localized form of nodular tenosynovitis has a higher incidence in woman and occurs predominantly in the hand. The clinical symptoms are not characteristic and usually not very pronounced. More than one tumor in a single patient and also bone erosions caused by nodular tenosynovitis are rare occurrences. A case of a patient with multilocular occurrence of tenosynovitis is described here.

Elbow↗
PubMed1976

[A new ceiling microscope suspension for plastic and reconstructive microsurgery].

Since 1969, 168 microsurgical interfascicular nerve transplantations have been performed in the Department for Hand Surgery and Plastic Surgery in the Surgical Clinic of the University of Erlangen. Since the end of 1974, the Zeiss Operation Microscope OPMI 2 has been hung from an electrohydraulic ceiling suspension and has proved invaluable. The construction and function of the apparatus is described. Such suspension of the microscope in combination with original Hanau operation lights, facilitates microsurgery in hand and plastic surgical procedure by saving space, reducing operating time and providing a better opportunity of ensuring sterility in the operating field.

Humans↗