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Biomedical subjects

J Garriga

Publications and source records attributed to J Garriga.

47 records · Page 3Linked to original sources

Thyroidal hemiagenesis.

Three cases of thyroidal hemiagenesis have been reported. The patients were euthyroid and presented with adenomatous goiters; one uninodular and the others multinodular in the contralateral lobe. In two cases the diagnosis was established by the thyroid stimulation test and confirmed at operation. In one case, this test was not performed and the hemiagenesia was discovered at routine surgical exploration of the scintigraphically absent lobe. From our cases and review of the literature we have concluded that the anomaly is usually discovered while searching for a contralateral pathologic abnormality, a thyroid stimulation test is essential for a preoperative suspicion, it occurs more frequently among women and in the left lobe, and ours are the first cases reported from Spain.

Adenocarcinoma↗

Clinical and pathologic evaluation of 342 benign ovarian tumors.

A series of 289 patients who were diagnosed with 342 benign ovarian tumors (BOT) at laparotomy have been reviewed. Mean age was 36.7 years (S.D. +/- 13.9), mean parity was 1.5 (S.D. +/- 1.6); 236 (81.7%) patients had a single unilateral ovarian tumor; 29 (10%) patients had bilateral ovarian tumors. Benign cyst teratoma was diagnosed in 89 (26%) tumors, and it was the most frequent histological type. In eight patients (2.8%) the post-operative pathologic report was compatible with malignancy, despite the lack of suspicion at laparotomy. Mean maximal diameter of BOT was 9.1 cm, and almost 60% of the mucinous cystoadenomas were larger than 16 cm. Benign cyst teratoma and serous cytoadenoma had a medium size, about 6-10 cm. Lower abdominal-pelvic pain was the symptom most frequently reported by patients with BOT. Calcifications were most frequently seen in benign cyst teratoma. Tumors of 11-15 cm in size were the tumors most frequently torsioned. Twenty four (8.3%) patients had their surgical operation done during pregnancy; benign cyst teratoma was the tumor most frequently associated with pregnancy.

Adolescent↗

Parietal cell volume, hypergastrinemia, and gastric acid hypersecretion after small bowel resection. Experimental study.

One hundred and fifty male Sprague-Dawley rats were divided into six groups: control, antrectomy, truncal vagotomy with pyloroplasty, intestinal resection, antrectomy with intestinal resection, and truncal vagotomy with pyloroplasty and intestinal resection. In the control group gastric acid secretion and plasma levels of gastrin were calculated. In the other five groups the same calculations were made 3 months after the corresponding operations. In all animals samples of the gastric wall were taken after specific dyeing of the parietal cells of these samples. In all samples prepared in this way, the variables of parietal cell volume per unit of muscularis mucosa were obtained by a morphometric method. The statistical survey using the levels of gastric acidity, gastrinemia, and parietal volumes of the six groups of animals showed that there is no relation between gastrinemia and gastric acid secretion, nor between gastrinemia and parietal volume, but that there is a significant correlation between gastric acid secretion and parietal volume. Those results suggest that the parietal cell volume in the rat decreases when the secreting capacity of the mucosa is decreased, and that the plasma levels of gastrin do not have a direct trophic effect on the parietal cells of gastric mucosa.

Animals↗

Gonadal dysgenesis (46,XY) and gonocytoma.

A case of 46,XY gonadal dysgenesis with a type III Teter's gonocytoma occurred in the left ovary of a 22-year-old woman. Hormonal, genetic and laparoscopic studies were performed before the diagnosis of gonadal dysgenesis was made. Gonadal neoplasm was found after bilateral gonadectomy.

Adult↗

Ethanol inhibits skeletal muscle cell proliferation and delays its differentiation in cell culture.

Chronic ingestion of ethanol (EtOH) produces physiological and morphological alterations in skeletal muscle. The effects of EtOH on skeletal muscle have been studied in experimental animals or on biopsies from alcoholic patients. However, alterations in skeletal muscle from alcoholic patients could be secondary to the effects of EtOH on the nervous system. In this study, by assaying the action of EtOH on primary skeletal muscle cell cultures, we provide evidence of its direct effect on skeletal muscle proliferation and differentiation. The results indicate that EtOH: (1) significantly inhibits skeletal muscle cell proliferation at the beginning of the proliferation phase; (2) delays skeletal muscle differentiation, shown by the significant changes in the evolution of the percentage of the creatine kinase isozymes; (3) has no significant effect on skeletal muscle DNA or protein content during the proliferation phase.

Animals↗

[Leiomyoma of the rectum. A diagnostic and therapeutic dilemma].

A case is reported of leiomyoma of rectum, a rare tumor since it is detected in 2 of 3000 rectal tumors. It occurs principally in patients between 40 and 50 years. The tumor is submucosal, is difficult to diagnose and biopsy is often valueless since it does not involve the tumor mass. The interest of the present case is that trans-rectal ultrasound imaging of the leiomyoma was performed. Differential histologic diagnosis between benign and malignant forms is a dilemma, these tumors being of slow growth with a marked tendency for recurrence and malignant degeneration. Treatment should always be surgical, with local resection if histology has excluded malignancy, followed by periodic surveillance. Radical surgery is indicated in malignant forms or for local recurrence of benign tumors.

Adult↗

Hepatic trauma.

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Adolescent↗

[Variations in post-small bowel resection gastric acid hypersecretion and hyper-gastrinemia after vagotomy and antrectomy. Experimental study in rat (author's transl)].

Resection of the small bowel provokes gastric acid hypersecretion and hyper-gastrinemia. Various studies have been conducted to assess the effects of vagotomy and antrectomy on post-resection gastric hyperacidity, both on basal levels and those after stimulation with histamine and pentagastrin. Similar studies involved hypergastrinemia levels. A total of 100 Sprague-Dawley rats were divided into 6 groups : controls (C). massive small bowel resection (R), vagotomy plus pyloroplasty (VP). antrectomy (A), vagotomy plus pyloroplasty and bowel resection (VPR), and antrectomy plus bowel resection (AR). - It was demonstrated that vagotomy is the most effective method for reducing gastric acid hypersecretion after small bowel resection. Antrectomy provokes diminution of gastric acid secretion in animals without bowel resections, but neither this nor gastrinemia levels are significantly altered in operated animals. Synergistic action of the mechanisms provoking post-resection and post-vagotomy hyper-gastrinemia is observed when they occur in the same group of animals, the incidence being higher than that observed after vagotomy or resection alone. Gastrinemia levels increased after VPR or reduced after AR cannot be differentially transposed to gastric secretion in these two groups of animals, demonstrating that, under these conditions, blood gastrin levels are not the principal factor involved in gastric secretion control.

Animals↗