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Biomedical subjects

J Gardner

Publications and source records attributed to J Gardner.

At least 145 records · Page 8Linked to original sources
PubMed1999

Sugar daddy. Most Americans know Medicare as the health insurance program for the elderly, but to providers, it's a jobs program, a capital financier and a safety net.

Most Americans know Medicare as the health insurance program that covers the elderly. But to providers it's much more that. The program pays for medical education, finances capital projects and subsidizes care for the indigent. Should Medicare continue making those add-on payments? Is that the program's mission? The debate is intensifying.

Aged↗
PubMed1999

HMO showdown. As House vote nears, managed-care lobby works to cut losses.

As the showdown over HMO patient protection nears in the House, the managed-care lobby realizes it probably has already lost the key battle over whether patients will have the right to sue their health plans. It's only a matter of how strong the final bill will be. The legislation also presents a dilemma for GOP leaders, who are trying to contain the issue and keep it from becoming campaign fodder.

Health Care Reform↗
PubMed1999

An HLA-A2 polyepitope vaccine for melanoma immunotherapy.

Epitope-based vaccination strategies designed to induce tumor-specific CD8 CTL are being widely considered for cancer immunotherapy. Here we describe a recombinant poxvirus vaccine that codes for ten HLA-A2-restricted epitopes derived from five melanoma Ags conjoined in an artificial polyepitope or polytope construct. Target cells infected with the melanoma polytope vaccinia were recognized by three different epitope-specific CTL lines derived from HLA-A2 melanoma patients, and CTL responses to seven of the epitopes were generated in at least one of six HLA-A2-transgenic mice immunized with the construct. CTL lines derived from vaccinated transgenic mice were also able to kill melanoma cells in vitro. Multiple epitopes within the polytope construct were therefore shown to be individually immunogenic, illustrating the feasibility of the polytope approach for melanoma immunotherapy. Tumor escape from CTL surveillance, through down regulation of individual tumor Ags and MHC alleles, might be overcome by polytope vaccines, which simultaneously target multiple cancer Ags.

Amino Acid Sequence↗