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Biomedical subjects

J Gardner

Publications and source records attributed to J Gardner.

679 records · Page 38Linked to original sources
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Urinary incontinence in the elderly.

Incontinence is a distressing, complex health problem which disproportionately affects older people. It is commonly endured silently, with many sufferers and carers not receiving appropriate support. In addition, incontinence is generally poorly managed both by families and health-care professionals, and is a major contributing factor in the institutionalization of the elderly. This paper argues that incontinence experienced in later life is often multifactorial in nature, thus health care professionals need to be cognizant of the many causes of incontinence, as well as the impact of lifestyle factors and 'normal' ageing processes. Incontinence in the community-based elderly can be cured or significantly improved in over 60% of cases with conservative management. Unfortunately community and professional attitudes and ignorance remain major barriers to continence.

Aged↗
PubMedDate not supplied

Health fair & CPR training: a successful community outreach, partnering & marketing opportunity.

The Penn State Geisinger Cardiovascular Center at the Milton S. Hershey Medical Center offered a free public Health Fair with Cardiopulmonary Resuscitation (CPR) training on February 28, 1998. This program was provided in recognition of Pennsylvania's "Heart Month" and benefited the Central Pennsylvania community. This article details the rationale, planning, implementation, as well as the proven marketing advantages for providing such an event.

Anniversaries and Special Events↗
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Cauda equina syndrome secondary to disseminated zygomycosis.

We describe a case of cauda equina syndrome secondary to disseminated zygomycosis. A 52-year-old man had myelodysplastic syndrome, progressive weakness of the lower extremities, and incontinence. Neuroradiological findings were consistent with lumbar stenosis and probable disk herniation. A lung lesion was also discovered on the chest roentgenogram. The patient's condition rapidly deteriorated after surgical decompression. Attempts at determining other etiologies were unsuccessful. At autopsy, disseminated zygomycosis was found affecting the lung and the vasculature of the cauda equina and lumbosacral nerve roots, with resultant focal demyelination of these structures. Ribbon-like hyphal elements were also present in the caudal roots. This opportunistic pathogen is discussed along with the diagnostic challenge presented by its unusual clinical presentation.

Autopsy↗
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Ascitic fluid cytology in a case of metastatic malignant mixed mesodermal tumor of the ovary.

The cytologic features of the abdominal fluid from a patient with a malignant mixed mesodermal tumor (MMMT) of the ovary are presented. Both malignant epithelial and stromal elements were cytologically appreciated and confirmed by histologic examination. Other ovarian neoplasms that can present with malignant sarcomatous elements or mixed epithelial and sarcomatous elements are discussed; this case documents the importance of recognizing these features when staging patients with unusual ovarian neoplasms. To our knowledge, this is the first complete report of the ascitic fluid cytology of an MMMT of either ovarian or uterine origin.

Aged↗
PubMedDate not supplied

Modification of the carboxyl terminal group affects replacement set analysis of a cytotoxic T cell epitope.

An Epstein-Barr virus-specific cytotoxic T cell (CTL) clone was previously shown to recognize the epitope FLRGRAYGL. The ability of substituted peptides to sensitize target cells for lysis by this clone was investigated using two peptide replacement sets, one synthesized with free carboxyl termini and another made with a carboxyl terminal beta-alanine-diketopiperazine (beta A-DKP) group. Curiously, the effect of certain substitutions differed for the two peptide sets. For example, NH2-FLRGRAYGL-beta A-DKP was 15-fold more active than NH2-FLRGRAYGI-beta A-DKR, but NH2-FLRGRAY-GL-COOH had the same activity as NH2-FLRGRAYGI-COOH. Evidence presented here illustrates that the activity of beta A-DKP peptide preparations was entirely due to contaminating peptides with free-COOH termini. The amount of active-COOH contaminants within a -beta A-DKP preparation thus appeared to vary depending on the substitution, resulting in some anomalous results from replacement set analysis using -beta A-DKP peptides.

Amino Acid Sequence↗