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Biomedical subjects

J Gardner

Publications and source records attributed to J Gardner.

At least 37 records · Page 2Linked to original sources
PubMed2001

2001 up & comers.

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Awards and Prizes↗
PubMed2001

Cytotoxic T cell polyepitope vaccines delivered by ISCOMs.

CD8 alphabeta cytotoxic T lymphocyte (CTL) polyepitope or polytope vaccines have traditionally been delivered using recombinant vector or DNA based delivery modalities. Here we show the delivery of polytope vaccines in the form of either synthetic polypeptides or recombinant polytope proteins by ImmunoStimulatory COMplexes (ISCOMs(R)). Induction of multiple protective CTL responses by these polytope-ISCOM formulations were comparable to viral vector or DNA based delivery modalities as assessed by IFNgamma ELISpot, chromium release and viral challenge assays. Measurement of CTL responses specific for the different epitopes revealed immunodominance patterns, which were largely independent of the vaccine vector or the order of the epitopes in the polytope. ISCOMs thus emerge as a viable human delivery modality for protein-based polytope vaccines.

Amino Acid Sequence↗
PubMed2001

Who holds the cards in healthcare poker?

Healthcare has always been a tricky game in Washington. Reaching consensus has often been almost impossible. Now, two months after James Jeffords defected from the Senate GOP fold, handing control to the Democrats, shifting coalitions are creating an even more volatile environment.

Health Care Reform↗