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Biomedical subjects

J G Wall

Publications and source records attributed to J G Wall.

15 recordsLinked to original sources

Wine tasting and dental erosion. Case report.

A case of widespread dental erosion is reported in an individual who had worked in the wine industry for ten years. This occupation involved daily tasting of at least 20 wines, but often more. The erosion manifested as dental sensitivity with there being cervical erosion, occlusal pitting, and loss of enamel around restorations. The effect of immersing unerupted human teeth in white wine (pH 3.3) was examined with the scanning electron microscope, where marked surface changes had occurred after 24 hours of exposure.

Adult

Phase II trial to topotecan in hepatocellular carcinoma: a Southwest Oncology Group study.

Hepatocellular carcinoma remains a highly chemoresistant neoplasm. In this study of the topoisomerase I inhibitor topotecan a response rate of 13.9% (95% confidence interval 4.7%-29.5%) was obtained utilizing a five consecutive day bolus infusion schedule. There were no complete responses and the median survival was only eight months. Furthermore, treatment with topotecan produced significant toxicity with two-thirds of patients experiencing life-threatening (grade 4) neutropenia. When used in this dose and schedule, topotecan does not appear to be effective for patients with advanced hepatocellular carcinoma.

Adult

Enamel erosion related to winemaking.

Enamel erosion is a recognized problem in those ingesting large quantities of fruit juice. While discomfort of the teeth is acknowledged to be a problem for those people tasting wines regularly, the information is anecdotal. A case is presented of a winemaker who has generalized erosion of the teeth, the onset of which is related to his occupation.

Adult

Effects of overexpressing folding modulators on the in vivo folding of heterologous proteins in Escherichia coli.

Interest continues to increase in the use of folding modulators to overcome problems with heterologous protein folding in Escherichia coli. Currently, this approach, though highly successful with a number of individual proteins, remains a somewhat hit-and-miss affair. Ongoing research directed at unraveling the precise role and specificity of these folding modulators should generate a clearer understanding of the potential and limitations of overexpressing folding catalysts in vivo. This will facilitate the development, in the not too distant future, of a more structured and rational approach to improving the folding of heterologous gene products in E. coli.

Endopeptidases

Cement luting thickness beneath porcelain veneers made on platinum foil.

Porcelain laminate veneers were made using a platinum foil matrix and were subsequently cemented to mandibular anterior Cymel teeth. Cement film thickness was measured in six predetermined locations. Repeated measures analysis of variance and single degree of freedom contrasts delineated a significant difference between marginal openings at the incisal edge where foil is folded and in four of the other vertical areas (132 versus 74.1 microns). Marginal cement film thickness of veneers made on platinum foil is less than that reported for veneers made on a refractory investment.

Analysis of Variance

A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days.

Topotecan (SK&F 104864) is a novel antitumor agent whose mechanism of action is inhibition of the DNA unwinding protein topoisomerase I. An analog of camptothecin, topotecan was designed to be more water soluble in an effort to decrease the severe and sporadic toxicities experienced during phase I/II trials of the parent compound. In this phase I clinical and pharmacological trial, topotecan was given as a bolus intravenous (i.v.) infusion over 30 min every 21 days. A total of 42 patients entered the study, receiving doses ranging from 2.5 to 22.5 mg/m2. The maximum tolerated dose (MTD) of topotecan given in this schedule was 22.5 mg/m2. Myelosuppression, primarily neutropenia, was dose-limiting. The extent of prior therapy did not predict for more severe neutropenia. Non-hematologic toxicities were mild and included low-grade to moderate fever, nausea, vomiting, alopecia, diarrhea and skin rashes. There were no objective partial or complete responses, although there was a suggestion of antitumor activity in three patients. Topotecan undergoes pH-dependent hydrolysis of the lactone ring; only the closed, lactone form is active. The lactone form predominated during infusion, with hydrolysis occurring rapidly following the end of infusion. There were linear relationships between dose administered and peak plasma lactone concentrations as well as AUC lactone to AUC total. The lactone was rapidly cleared from plasma with a total body clearance of 25.7 (+/- 6.7) l/h/m2. The plasma lactone concentration declined rapidly with a harmonic mean terminal half-life of 3.4 (+/- 1.1)h. Lactone hydrolysis and renal excretion were the major routes of elimination.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult

Alternative crown systems. Is the metal-ceramic crown always the restoration of choice?

The metal-ceramic crown system still is selected the most frequently because of its strength and versatility. The ability to select metals for color or strength for single units or fixed partial dentures gives great flexibility, but when esthetics of the anterior region are a prime concern, the all-ceramic crown is still an excellent choice. Choice of which all-ceramic system to use is dependent on the strength demands, esthetic needs, amount of tooth structure that can be preserved, and laboratory support available. Where good tooth structure remains but some color, contour, or incisal length changes are desired, the porcelain laminate veneer is an outstanding esthetic and restorative choice. When good labial tooth structure remains but lingual structure is inadequate, a partial veneer gold crown can be an excellent esthetic choice. If moderate tooth structure is lost or moderate staining is present, the Dicor crown is a superb choice. In those instances in which heavy staining is present, a foil or core system should be considered to completely block out the background colors. As the occlusal forces become more of a factor, selection of a restorative system will depend more on strength than esthetic demands. The aluminous porcelain jacket crown still offers great strength and esthetics at a reasonable price. When most of the color is on the surface of the teeth, or when there is a high translucency to the teeth, Dicor can provide very esthetic results, and the Dicor Plus crown offers the opportunity to develop intrinsic shading. When greater strength is required, selection of a foil and core system is suggested, as might be a system that provides a stronger core material, like Alceram or Inceram. These stronger core materials will render improved flexural and compressive strengths, but some increases in brightness may occur with the increased alumina content of the cores. The future in ceramic restorative dentistry may be in the computer-generated crown if ways to develop internal coloring and layered building can be developed and cost can be controlled. Ceramic crowns are best limited to the anterior region of the mouth where occlusal forces normally are less than those found in the posterior region. In selected cases, in which there is no evidence of parafunctional habits, and when the dentist and technician are well versed in functional occlusion and have maximum restorative control of the occlusion, posterior ceramic restorations will be successful. It is important to remember in these cases that porcelain is harder than enamel and very strong in compression.(ABSTRACT TRUNCATED AT 400 WORDS)

Aluminum Oxide

Esthetics in fixed and removable prosthodontics shade selection in metal-ceramics.

Many factors affect selection of the proper shade for metal-ceramic restorations. The purpose of this paper was to present the inherent limitations in accurate shade determination and discuss methods to control these limitations. A systematic approach is presented as an aid for attaining accurate shade selection. Using this approach will enable the dentist to place more esthetic restorations.

Color

Esthetics in fixed and removable prosthodontics: the composition of a smile.

The composition of an esthetic smile can be an elusive goal. The purpose of this paper is to present and clarify the principles of perception and the common errors in dental esthetics. A review of the literature is distilled into basic building blocks for composing the esthetic smile. Utilization of the principles presented here will allow the practitioner+ to improve the appearance of fixed and removable restorations.

Denture Design

Arterial thrombosis associated with adjuvant chemotherapy for breast carcinoma: a Cancer and Leukemia Group B Study.

PURPOSE: Multiagent chemotherapy and chemohormonal therapy for breast cancer are associated with an increased risk for venous thromboembolic complications. We observed instances of arterial thrombosis in two studies of breast cancer involving multiagent chemotherapy for stages II and III disease. Our purpose in this study was to determine the incidence of this complication and whether it appeared to be related to the chemotherapy or was a random event. PATIENTS AND METHODS: Episodes of arterial thrombotic events were identified from record reviews of 1,014 assessable patients with breast cancer entered on two Cancer and Leukemia Group B protocols. Details of the kind of arterial event, when it occurred, the outcome, and the occurrence of metastases were analyzed. RESULTS: Thirteen (1.3%) patients had an arterial thrombosis: six (5.3%) of 113 patients with stage III disease and seven (0.8%) of 901 patients with stage II disease. Four of these patients had a peripheral arterial thrombosis and nine had strokes (four were fatal). All these events occurred while the patients were receiving adjuvant chemotherapy. Only one additional arterial event (a stroke approximately four years later) has occurred in this patient group after chemotherapy was completed. CONCLUSION: Arterial thrombosis is also associated with multiagent chemotherapy in patients with breast cancer. The mechanism is unknown.

Aged

Hairy cell leukemia presenting as a lupus-like illness.

We describe a young Hispanic man who presented with features suggestive of a diagnosis of systemic lupus erythematosus. Eventually, a bone marrow biopsy was performed, and it revealed the presence of hairy cell leukemia. This case of a lupus-like syndrome should be added to the list of reported rheumatic syndromes that are associated with hairy cell leukemia.

Adult

Incisal-edge strength of porcelain laminate veneers restoring mandibular incisors.

Porcelain laminate veneers can be used to increase incisal-edge length. The purpose of this study was to determine the fracture resistance of porcelain veneer restorations on Cymel 1077 mandibular incisors that were incisally reduced 0.0, 0.5, 1.0, and 2.0 mm. Variables studied were incisal-edge length and the angle of applied force. Sixty-one porcelain laminate veneers were made to restore incisal-edge length and bonded to the prepared teeth. Samples were fractured at force angles of 130 degrees and 137 degrees. No significant difference was found between varying incisal-edge lengths (P > .05). However, the lower applied angle required greater average force to fracture (P = .005) as tested by ANOVA.

Analysis of Variance

Collaborative Care.

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Dental Care