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Biomedical subjects

J G Shire

Publications and source records attributed to J G Shire.

49 records · Page 3Linked to original sources
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Corticosterone catabolism by mouse liver homogenate: strain difference in dependence on added NADP.

The C57BL/10ScSn and DBA/2J strains of mice differed in the rate at which corticosterone was reductively catabolised by liver homogenates when the animals had been fed a diet low in fat. The addition of an NADPH generating system to the homogenates increased the catabolism of corticosterone. Its greatest effect was on the homogenates from DBA mice given a fat-free diet and its least effect on those from C57 mice fed a standard diet. The addition of NADP was similar in its effect to the addition of the complete NADPH generating system. Glucose-6-phosphate dehydrogenase stimulated corticosterone breakdown only in homogenates from C57 mice on the standard diet. The addition of glucose-6-phosphate had no effect. NADP was the only effective stimulator of corticosterone reduction in homogenates from CBA/FaCam mice.

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Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice.

Beige, bg, and reduced pigmentation, rp, are recessive mutations affecting lysosomal function. Homozygosity for beige prevented lipofuscinosis of the spleen in C57BL mice and its incidence was greatly reduced by homozygosity for rp. Dilute (d) homozygotes, with normal lysosomes, were susceptible to lipofuscinosis even though their melanosomes were more severely affected than those of beige mice.

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