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Biomedical subjects

J G Mosley

Publications and source records attributed to J G Mosley.

At least 37 records · Page 2Linked to original sources
PubMed1983

Long term results of 66 femoral-to-femoral by-pass grafts: a 9-year follow-up.

Over an 8-year period, 66 femoral-to-femoral grafts were performed for unilateral iliac artery disease. The grafts were inserted retropubically with an operative mortality of 4.5 per cent. The minimum follow-up has been 12 months and cumulative patency 80 per cent at 6 years. Sixteen patients had critical ischaemia (preoperative Doppler ankle pressure less than 40 mmHg) and 50 patients had severe ischaemia (preoperative ankle pressure greater than 40 mmHg). The graft significantly improved initial ankle pressures and this improvement was maintained at late follow-up (average 45 months). There was no evidence of a detrimental effect on the donor limb. Long term patency was adversely affected if there was preoperative critical ischaemia, a woven Dacron prosthesis was used or the patient continued to smoke.

Aged↗
PubMed1983

An assessment of long saphenous venography to evaluate the saphenous vein for femoropopliteal bypass.

A long saphenous venogram was performed on a consecutive series of 42 patients (5 bilateral) though in 4 the vein was not satisfactorily demonstrated. In all cases the long saphenous vein was dissected out and its suitability for use for a femoropopliteal bypass compared to the radiological findings. Eleven veins were unusable for a bypass and radiologically these were narrower (mean diameter 2.8 mm) than the veins which functioned satisfactorily (mean diameter 5.0 mm), and had more tributaries (mean 5) than the suitable veins (mean 2). Preoperative venography is a useful technique to identify veins that will be unsuitable for a femoropopliteal bypass and thereby save an unnecessary dissection.

Evaluation Studies as Topic↗
PubMed1981

Pancreatic function in domestic cats with pancreatic fluke infection.

Thirty-one of 290 cats (10.7%) from the area around St Louis, Mo, were infected with Eurytrema procyonis. In some cats, the pancreas was severely affected, with almost complete atrophy and fibrous replacement of the gland. Both bicarbonate and protein secretions were impaired, although clinically evident pancreatic insufficiency was not seen.

Animals↗
PubMed1981

Effect of 16, 16 dimethyl prostaglandin E2 on aspirin-induced permeability changes in the pancreatic duct.

Perfusion of the pancreatic duct with acidified aspirin in cats increased the permeability of the duct to HCO3-. Intravenous administration of the synthetic prostaglandin analog 16,16 dimethyl prostaglandin E2 (PGE2) prevented this permeability change. The effect was dose-related and at the highest dose (50 microgram/kg/hour) was essentially complete. The beneficial effect of the PGE2 was apparent even when it was given after the duct had been exposed to aspirin. PGE2 had no effect on pancreatic water or electrolyte secretion in the unstimulated nonsecreting gland. No histologic changes in the pancreatic ducts were seen after exposure to aspirin, PGE2 or both. The effectiveness of PGE2 in restoring membrane permeability towards normal suggests the possibility of its therapeutic role in pancreatitis.

16,16-Dimethylprostaglandin E2↗
PubMed1980

The effect of bile salts on the pancreatic duct mucosal barrier.

The effects of various bile salts on the permeability of the pancreatic duct in cats have been investigated. The sodium salts of cholic, glycocholic, taurocholic, chenodeoxycholic, glycochenodeoxycholic, deoxycholic and glycodeoxycholic acids were perfused through the main duct in concentrations similar to those found in the duodenal contents (15-42 mM). HCO3- and Cl- fluxes were determined before and after perfusion. The unconjugated dihydroxy bile salts increased permeability to these anions to a greater degree than the trihydroxy bile salt, but all were damaging to the duct when they were perfused at an alkaline pH (8.4-9.1). The glycine conjugates of the bile salts were as damaging as the unconjugated form, but 42 mM taurocholate was more damaging than 42 mM glycocholate. When 25 mM glycocholate was perfused at pH 2.4 there was potentiation of the damage produced during perfusion of glycocholate at pH 8.7. Sterile cat bile did not damage the duct, but infected bile did. The ability of bile salts to increase the permeability of the pancreatic ducts must be considered as a possible aetiological factor in the pathogenesis of inflammatory and malignant diseases of the pancreas.

Animals↗
PubMed1980

Haemorrhoids--objective measurement of proctoscopic appearances.

The proctoscopic diagnosis of haemorrhoids may be influenced by the surgeon's knowledge of the presence or absence of associated symptoms. In this study, an observer with no knowledge of the history, was used to check the surgeon's proctoscopic findings in 12 asymptomatic controls, and 24 symptomatic patients on 2 occasions, the latter group undergoing McGivney rubber band ligation. There was very good correlation between the findings of the surgeon and the observer, indicating a lack of 'historical bias'. The documentation method designed to allow this comparison proved sufficiently accurate and reproducible to enable a correlation between haemorrhoidal mass and symptoms. Relief of symptoms after treatment correlated well with an objective reduction in haemorrhoidal mass.

Adult↗
PubMed1978

Arterial anastomoses in renal transplantation.

A consecutive series of 260 renal transplants was analysed to find the outcome of different arterial anastomoses. In 177 cases the renal vessel was anastomosed to the end of the internal iliac artery; 15 per cent developed vascular complications. Thirty-eight of these patients subsequently underwent allograft nephrectomy; none died from haemorrhage. In 83 patients the renal vessel was anastomosed end to side to the iliac artery, and vascular complications occurred in 14 per cent. Thirty-two patients subsequently underwent allograft nephrectomy; 8 were associated with severe haemorrhage and 5 of these were fatal.

Female↗
PubMed1978

Effects of amputation and Corynebacterium parvum on tumour metastases in mice.

The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated. Anaesthesia alone or with amputation did not affect primary tumour growth. C. parvum depressed this growth. Anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. C. parvum inhibited metastases and completely counteracted the effects of operation on them. Large doses of cortisone acetate significantly increased metastases but small doses had no effect. Experiments with adrenalectomized mice suggested the effects of operation were due to non-specific stress.

Adrenalectomy↗
PubMed1977

Prevention of wound infection in abdominal operations by peroperative antibiotics or povidone-iodine. A controlled trial.

The wound-infection rate after abdominal operations was compared in 113 patients randomly allocated to an untreated control group, a group receiving preoperative lincomycin and tobramycin, or a group receiving local instillation of povidone-iodine. The wound-infection rate was 8.1% in 37 patients receiving antibiotics, 42.1% in 38 untreated controls, and 39.5% in 38 patients in the povidone-iodine group.

Abdomen↗