Biomedical subjects

J G Lanham

Publications and source records attributed to J G Lanham.

22 records · Page 2Linked to original sources

PubMed1982

Familial amyloidosis of Ostertag.

A 23 year old Englishman presented with keratoconjunctivitis sicca and was found to have systemic amyloidosis. Five members of his family in two generations also had non-neuropathic amyloid particularly affecting the kidneys. This conforms to the Ostertag type of hereditary amyloidosis. Amyloid deposits in the proband showed permanganate-sensitive Congophilia and positive immunofluorescence staining for P component, but were negative for amyloid A and prealbumin. These observations suggested that the fibril protein in this patient was immunochemically distinct from the amyloid fibrils characterized hitherto.

Adult↗

PubMed1981

The effect of a protein meal on three fluid-phase assays for circulating immune complexes.

Serial blood samples were taken from eight patients with systemic lupus erythematosus and five normal controls before and after a standard meal containing 20 g of protein. The samples were assayed for circulating immune complexes by the fluid-phase C1q, monoclonal rheumatoid factor and conglutinin-binding assays. No significant differences were seen in the post- as compared to the pre-prandial levels of circulating immune complexes. In neither controls nor patients did circulating complexes appear for the first time within 90 min after starting the meal. We conclude that if systemic antigen--antibody reactions occur soon after a protein meal they are not detected by the polyethylene glycol-dependent tests in current use and do not appear to influence the immediate clearance of endogenous immune complexes.

Antigen-Antibody Complex↗

PubMedDate not supplied

Churg-Strauss syndrome.

The presentation of Churg-Strauss syndrome is most distinctive, permitting diagnosis on clinical grounds. It is a phasic disorder with allergic rhinitis and asthma initially, often followed by peripheral blood eosinophilia with eosinophilic tissue infiltrates. The vasculitic illness is the life-threatening phase, but it can be effectively suppressed by prompt treatment.

Adult↗

PubMedDate not supplied

Renal vein thrombosis in systemic lupus erythematosus: association with the "lupus anticoagulant".

Two patients with lupus erythematosus and renal vein thrombosis are described. Both patients had the "lupus anti-coagulant" in their serum. It is postulated that in these patients the clotting tendency could be favoured by a cross reaction of the "lupus anti-coagulant" with phospholipids in the endothelial cell membrane, resulting in inhibition of prostacyclin release.

Adolescent↗