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Biomedical subjects

J G Fox

Publications and source records attributed to J G Fox.

At least 361 records · Page 20Linked to original sources
PubMed1978

Analysis of lead in animal feed ingredients.

Analyses for lead content were done on 124 specific feed ingredients from 5 major pet food companies. The lead content of the different ingredients varied from 0.1 parts per million (ppm) to 3,600 ppm. Of the samples 48 (39%) had greater than 1 ppm lead. In particular, one type of ingredient (mineral mix) was contaminated with large amounts of this element. Feeds that contain a marked amount of lead could add an uncontrolled variable to experiments using laboratory animals and could cause misinterpretation of experimental results.

Animal Feed↗
PubMed1978

Hematologic and serum protein reference values of the Octodon degus.

Blood and serum from normal degus (Octodon degus) that ranged in age from 3 to 48 months were analyzed to determine reference hematologic and serum protein values. Both sexes were evaluated and were similar. The hematologic and serum protein values for males were: erythrocytes, 8.69 +/- 0.19 X 10(6) /microliter; packed cell volume, 42.1% +/- 0.59%; hemoglobin, 12.0 +/- 0.15 g/dl; leukocytes, 8.50 +/- 0.39 X 10(3)/microliter; neutrophil-to-lymphocyte ration, 40:60; and total protein, 5.70 +/- 0.20 g/dl. The hematologic and serum protein values for females were: erythrocytes, 8.94 +/- 0.16 X 10(6)/microliter; packed cell volume, 40.0% +/- 0.61%; hemoglobin, 11.7 +/- 0.17 g/dl; leukocytes, 8.20 +/- 0.36 X 10(3)/microliter; neutrophil-to-lymphocyte ratio, 40:60; and total protein, 5.62 +/- 0.18 g/dl. The hematologic and serum protein values for the degu were similar in some respects to values reported for guinea pigs and rats.

Animals↗
PubMed1977

Salmonella-associated conjunctivitis in a cat.

Salmonella typhimurium-associated conjunctivitis in an adult female cat was characterized by epiphora and blepharospasm. The cat also harbored intestinal S typhimurium, as did one other cat in the same shipment of 7 cats obtained from a commercial cat dealer. The 3 isolates were resistant to ampicillin, cephaloridine, cephalothin, streptomycin, triple sulfonamides, and tetracycline. All 3 isolates were capable of transferring a part of the antibiotic resistance pattern to an Escherichia coli K-12 recipient. Salmonella were not recovered from the conjunctiva or fecal flora of either cat after 10 days of therapy with chloramphenicol.

Animals↗
PubMed1977

Mycotic enteritis in a chameleon and a brief review of phycomycoses of animals.

Rectal prolapse in an adult chameleon was surgically replaced. The animal was given tetracycline and dextrose orally, but became comatose 7 days postoperatively and was euthanatized. Necropsy revealed intussusception of the terminal portion of the colon. Phycomycotic hyphae accompanied by necrosis and a mixed leukocytic infiltrate were found in the area of intussusception.

Animals↗
PubMed1977

Adverse effects of mouse hepatitis virus on ascites myeloma passage in the BALB/eJ mouse.

During experimental serial passage of ascites myelomas through BALB/cJ mice, unexpected illness and premature deaths occurred. Postmortem examination of affected mice revealed focal or diffuse discolored depressed areas in the liver and, in some cases, splenomegaly. Histopathologic findings consisted of focal to diffuse areas of necrosis with minimal leukocytic infiltration. Aerobic and anaerobic bacterial cultures of livers and spleens from affected mice were negative. Mouse hepatitis virus (MHV) was isolated from livers of clinically ill mice and from the ascites myeloma lines. An MHV contaminated ascites myeloma line, when passed into nude (nu/nu) mice, killed the animals in 6 days; the virus was isolated from livers of inoculated mice. Attempts to determine the source of the infection were unsuccessful. Serologic survey of newly acquired mice indicated no evidence of antibodies to MHV while mice in holding rooms had titers that ranged from 1:10 to 1:40. Two solid myeloma lines (being maintained by subcutaneous passage) were negative for MHV when tested by virus isolation techniques, and nine lines were negative to 11 murine viruses when tested by mouse antibody production assay. Attempts to demonstrate Eperythrozoon coccoides in control BALB/cJ mice were unsuccessful. Because of the outbreak, changes were made in animal handling procedures. A colony of BALB/cAn mice negative to MHV antibodies was established to provide animals for experimental passage of tumors, and animals in both the breeding and transfer room were placed under filter tops. The results were encouraging. In the four newly established tumor lines, one having been passed 46 times, no illness or unexplained deaths were observed.

Animals↗
PubMed1977

Ulcerative dermatitis in the rat.

Ulcerative dermatitis observed in several shipments of rats was found to be limited to one strain (Sprague Dawley) provided by one supplier from two specific breeding areas. The incidence of lesions was higher in males than in females. Rats receiving an agar base diet also appeared to have a higher incidence of the lesions. The lesion consisted of a moist ulcer usually involving the lateral aspect of the shoulder and often the sides of the neck. Staphylococcus aureus was isolated from lesions of affected rats and from the skin of unaffected rats. Inoculation of S aureus into susceptible animals resulted in lesions in 25-40% of the rats, but usually at sites other than the site of inoculation. Serum neutralization tests for sialodacryoadenitis virus indicated that about half the rats with lesions and half the rats without lesions were positive. Toenail clipping of the hind feet of affected rats reduced the severity of the lesions. Efforts to isolate fungi and ectoparasites were unsuccessful. The selective procurement of rats from specified breeding areas, eliminated the population susceptible to or harboring the etiologic agent or agents responsible for the development of the ulcerative dermatitis described.

Animals↗
PubMed1976

Cheyletiella infestation in cats.

While routinely examining a fecal specimen of a cat for evidence of intestinal parasitism, large eggs (230 by 110 mu) were observed. tfurther examination of the fecal specimen revealed an adult Cheyletiella sp. mite. Of 42 cats received from the same source, 11 had Cheyletiella mites, found either on the skin or in fecal specimens. Grossly visible skin changes were not observed in any of the cats. The conically shaped sensory organ on genu I of the mite resembled that of Cheyletiella blakei.

Animals↗
PubMed1976

Lead in animal foods.

Analyses for lead content were carried out on 78 random samples of pet food (purchased in local grocery outlets) and on 25 individual rations for laboratory animals. The lead content of 46 samples of cat food ranged from 0.1 to 7.6 mug/g, 32 dog foods ranged from 0.1 to 3.4 mug/g, and 25 laboratory animal feeds ranged from 0.1 t0 4.0 mug/g. Foods that contain a significant amount of lead could add an uncontrolled variable to experiments using laboratory animals and may cause misinterpretation of experimental results.

Animal Feed↗
PubMed1976

Disseminated staphylococcal disease in laboratory rabbits (Oryctolagus cuniculus).

The pathologic findings in 13 cases of staphylococcal disease in New Zealand white rabbits were described. Subcutaneous abscesses and embolic pyemic abscesses in kidney, heart, brain, and lung were found. Conjunctivitis, rhinitis, otitis media, and fibrinous pneumonia also occurred. One rabbit had a valvular endocarditis. Staphylococcus aureus, coagulase-positive, and fermenting mannitol were isolated from the lesions described. Staphylococcal disease was diagnosed in 13 of the 171 (7.6%) rabbits necropsied during a 3-yr period. Disseminated staphylococcal lesions were observed only in rabbits during this time.

Animals↗
PubMed1975

Meningitis caused by Klebsiella spp in two rhesus monkeys.

Two adult, female rhesus monkeys (Macaca mulatta) became depressed, weak, anorectic, and adipsic. Auscultation of the thorax of 1 monkey revealed bilateral harsh rales. Neither monkey responded to therapeutic doses of antibiotics, and both died soon after treatment was started. Meningitis was demonstrated histologically and pure cultures of multiply antibiotic-resistant Klebsiella were isolated from the brains of both monkeys. Of 13 clinically normal rhesus monkeys in the same facility, 5 had multiply antibiotic-resistant Klebsiella spp in their pharynges.

Animals↗
PubMed1975

Transmissible drug resistance in Shigella and Salmonella isolated from pet monkeys and their owners.

During two dysentery outbreaks in primate pet owners, Shigella and Salmonella strains were isolated from the enteric flora. In both outbreaks the source of infection was traced to asymptomatic spider monkeys (Ateles geoffroyi). The spider monkeys and their owners shed multiply drug-resistant Shigella and Salmonella serotypes. Six of the nine bacterial strains isolated from the animals were multiply drug-resistant and capable of transferring antibiotic resistance patterns.

Animals↗