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Biomedical subjects

J G Ferguson

Publications and source records attributed to J G Ferguson.

At least 37 records · Page 2Linked to original sources
PubMed1988

Ultrastructural study of synovial membrane from the antebrachiocarpal joint of calves.

The synovial intima from the antebrachiocarpal joint of 4-month-old calves was between 1 and 3 cells in thickness and did not have a basal lamina. Numerous areas of the intimal matrix were in direct contact with the joint lumen. The synovial membrane was comprised mainly of A-type synoviocytes usually located adjacent to the joint lumen. These cells were characterized by numerous filopodia (or lamellipodia), large, empty-appearing vacuoles, numerous lysosomes, large vacuoles containing granular material separated from the vacuolar membrane by a radiolucent band, and coated micropinocytotic vesicles. Smooth micropinocytotic vesicles were seen only rarely in these cells. In contrast, B-type cells had few filopodia, numerous smooth micropinocytotic vesicles, few coated micropinocytotic vesicles, a well-developed Golgi apparatus and rough endoplasmic reticulum, mitochondria that were longer and had a denser matrix than that of A cell mitochondria, and surprisingly, only few maturing or fully formed secretory granules. A distinct intermediate (C or AB) type synoviocyte could not be unequivocally identified. Desmosome-like structures were present between synoviocytes, although it was considered questionable if these were true intercellular junctions. No other junctions were present.

Animals↗
PubMed1986

Logistic analysis of risk factors in acute retinopathy of prematurity.

In a prospective study of 328 high-risk neonates, we used computer-assisted logistic regression of 47 potential risk factors to study acute retinopathy of prematurity. Only four factors were significant in the logistic regression equation: ventilator hours, xanthine administration, birthweight, and maternal bleeding. Xanthine administration was identified as a new independent and significant (P less than .0001) predictor of acute retinopathy of prematurity.

Female↗
PubMed1986

Corneal epithelial cells produce thromboxane in response to interleukin 1 (IL-1).

Synthesis of thromboxane, a product of arachidonic acid formed via the cyclooxygenase pathway, was studied in rabbit corneal epithelial cells (SIRC cell line) under resting conditions and under the influence of interleukin 1 (IL-1). IL-1 potentiated the production of thromboxane 3-10-fold in a dose-dependent manner. This finding assumes added significance in view of the previous observations that the same cells are capable of producing IL-1. Thus, the corneal epithelial cells may be viewed in this context as an autocrine cell producing two biologically active substances which can serve as mediators of inflammation, one of which can augment the production of the other.

Animals↗
PubMed1985

Special considerations in bovine orthopedics and lameness.

This article discusses the features that make bovine orthopedics a unique area. Changes in methodology and design of internal fixation devices are considered, particularly as they differ in application to the different age and weight categories. Pediatric and economic considerations and the importance of client communications are reviewed in detail.

Age Factors↗
PubMed1985

Principles and application of internal fixation in cattle.

The principles of bone healing and vascular and periosteal responses are considered in relation to different methods of fracture fixation and complications. Advantages and disadvantages of the available internal fixation devices are reviewed for the fractures that most commonly occur in the different age groups.

Animals↗
PubMed1985

Alternatives to amputation.

Amputation of the digit of valuable animals is an inappropriate technique for resolving the serious infective processes that involve the important structures of the distal interphalangeal region. Surgeons should be able to recognize the early clinical signs and radiographic indications of three distinct, but interrelated, phenomena--the septic joint, the retroarticular abscess, and the complication of tenovaginitis. Tenovaginitis depends on either the septic joint or retroarticular abscess for its etiology. In any of these complications, the effective treatment will be based on the removal of diseased tissue and on irrigation with drainage of the area, followed by the elimination of mechanical forces or movement in the affected region.

Abscess↗
PubMed1983

Management of umbilical hernias in cattle and horses.

The medical records of 60 cattle and 47 horses treated for umbilical hernia at the Western College of Veterinary Medicine over a 3-year period were studied retrospectively. Age, hernia size, physical signs at admission, reducibility, method of repair, prevalence, and types of complications were evaluated. Most patients were less than 6 months old, with hernias less than 10 cm long. Affected cattle had a higher prevalence of organic diseases associated with umbilical hernias and more postsurgical complications than did affected horses.

Animals↗
PubMed1982

Progressive visual loss, diabetes mellitus, and associated abnormalities (DIDMOAD syndrome).

A syndrome including juvenile-onset diabetes mellitus, optic atrophy, diabetes insipidus, and high-frequency sensorineural hearing loss, expressed completely or partially, is being identified with greater frequency. Visual loss may be progressive and accompanied by primary optic atrophy. Concurrent diabetic retinopathy has only rarely been reported. Visual acuity may deteriorate to less than 20/400. The etiology is unknown. However, histopathologic studies indicate that the diabetes insipidus, optic atrophy, and neurosensory hearing loss represent progressive degenerative conditions. Inheritance appears to be autosomal recessive with incomplete penetrance. The syndrome is rare; therefore, a complete neuroophthalmologic and neuroradiologic evaluation is imperative to rule out a mass lesion. This syndrome should be considered in young people with visual loss and optic atrophy of unknown etiology even if they are not known juvenile diabetics.

Adolescent↗
PubMed1981

Functional organization of the oculomotor nucleus in the baboon.

The functional organization of the oculomotor nucleus was investigated using horseradish peroxidase (HRP) histochemistry. In a series of baboons, injections of HRP were made into the skeletal muscles supplied by the oculomotor nerve (medial rectus, superior rectus, inferior rectus, inferior oblique, and the levator palpebrae superioris). After a 48-hour survival time the animals were sacrificed via perfusion-fixation and the brains treated according to the tetramethylbenzidine (TMB)-HRP method of Mesulam (1978). The inferior oblique, inferior rectus, medial rectus, and levator palpebrae superioris muscle are supplied by cells located primarily in the homolateral oculomotor nucleus. Some fibers to the levator palpebrae superioris arise from cells in both caudal central nuclei. The superior rectus muscle receives fibers from cells in the contralateral oculomotor nucleus. The results were compiled using a Lucite-plate reconstruction method that permits visualization of the three-dimensional configuration of the neuronal populations within the oculomotor nucleus. Oculomotor neurons are organized in a vertical column that may be anatomically divided into rostral, middle, and caudal thirds. A section through any of these levels may be further subdivided into dorsal, intermediate, and ventral zones. Each of the oculomotor skeletal muscles was found to have cells at almost all levels of the nucleus and in certain zones at each level. These functional cell groups intermingle with one another in the baboon and do not remain segregated into distinct subnuclei or subdivisions. Much overlap was evident between cells innervating the homolateral inferior rectus, homolateral inferior oblique, and the contralateral superior rectus muscles. There was also overlap between those cells supplying the homolateral levator palpebrae superioris and the homolateral medial rectus muscles.

Animals↗
PubMed1981

Clindamycin therapy for toxoplasmosis.

Clindamycin hydrochloride hydrate (Cleocin), a semisynthetic antibiotic shown experimentally to be effective in ocular toxoplasmosis in the rabbit, was used in the treatment of four patients with active retinochoroiditis secondary to toxoplasmosis. The drug was administered subjunctivally on alternate days for 30 days. Both subjective and objective evidence indicated beneficial results in these patients during the first 30 days. One of the four did not respond during the first 30 days but did respond during an extended period. One of those who responded initially had exacerbations when the drug was stopped and required treatment.

Adolescent↗
PubMed1979

A cytologic aid to diagnosing congenital glaucoma.

Using the Giemsa and Papanicolaou staining methods, the authors studied the superficial corneal epithelium of 17 glaucoma patients and 25 normal patients. Smears of the normal patients exhibited a high frequency of precornified cells and a paucity of cornified cells with pyknotic nuclei. Smears of the glaucomatous patients illustrated striking tinctorial changes; these changes were so pronounced that examination of a single section strongly suggested a diagnosis of glaucoma. A case report is presented in which a preliminary diagnosis of congenital glaucoma was disproved by these staining techniques.

Adolescent↗
PubMed1978

Tibiotarsal arthrodesis in a Moufflon sheep.

Restraint of a mature Moufflon sheep resulted in severe fracture and luxation of a previously osteoarthritic tibiotarsal joint. Arthrodesis was accomplished by means of internal pin fixation and an external fiberglass cast. After 3 months of hospitalization, the ram was returned to the original flock. Competition for dominance within the flock resulted in physical trauma to the ram. Seven months after surgery, the ram sustained a fractured ulna and died from exposure.

Animals↗