Biomedical subjects

J G Allen

Publications and source records attributed to J G Allen.

201 records · Page 12Linked to original sources

PubMedDate not supplied

Influence of a hospital-based wellness program on employee fitness.

The purpose of this study was to evaluate changes in aerobic fitness among female participants in a hospital-based wellness program. Subjects were divided retrospectively into control (n = 5) and experimental (n = 17) groups, based on their frequency of exercise during a supervised exercise program. The control group exercised less than two days a week, the experimental group exercised two to four days a week. Body weight, percent body fat, and estimated maximal oxygen consumption (VO2 max) were assessed before and after 6- to 12-months of individually prescribed exercise. Pre- and post-test results were analyzed with paired t tests. In the experimental group, body weight and percent body fat remained unchanged (P greater than .05) whereas estimated VO2 max increased significantly (P less than .05). No changes (P greater than .05) were observed in the control group. These results demonstrated that regular participation in a supervised exercise program can effectively increase aerobic fitness.

Adult↗

PubMedDate not supplied

Metabolism of debrisoquine sulfate. Identification of some urinary metabolites in rat and man.

A high proportion of an oral dose of 14C-debrisoquine sulfate is excreted in the urine by rat and man. The urinary radioactivity consists of a mixture of unchanged drug and polar, water-soluble metabolites which cannot be extracted into organic solvents. Treatment of methanolic extracts of the freeze dried urine with acetylacetone incorporates the amidino group of debrisoquine and these metabolites into a 4,6-dimethylpyrimidine ring, and yields derivatives which can be readily extracted from aqueous solution. Gas-liquid chromatographic-mass spectrometric studies of these extracts have shown that in both species: 1) the major metabolite is formed by 4-hydroxylation of debrisoquine; 2) a significant proportion of the dose is excreted as acidic metabolites, formed by opening the tetrahydroisoquinoline ring; 3) trace amounts of phenolic metabolites (5-, 6-, 7-, and 8-hydroxydebrisoquines) are also excreted.

Animals↗

PubMedDate not supplied

Postoperative analgesia following total knee arthroplasty: a study comparing spinal anesthesia and combined sciatic femoral 3-in-1 block.

BACKGROUND AND OBJECTIVES: The quality of analgesia and subsequent morphine requirements following spinal anesthetic block (SAB) or combined sciatic and femoral (3-in-1) block (SFB) for total knee arthroplasty were compared. METHODS: The 39 patients studied were randomly assigned to receive either SAB (n = 19) or SFB (n = 20). All patients received a standardized general anesthetic, patient-controlled analgesia, and regular diclofenac. Visual analog pain scores and morphine requirements were recorded for 48 hours following surgery. Observations were grouped into four 12-hour periods. Pain scores (0-10 cm) were expressed as 95% confidence intervals; the criterion for analgesic success was a confidence interval in the range 0-3 cm. RESULTS: Although pain-free on awakening, the SAB patients failed to achieve analgesic success in any of the four periods, while the SFB patients did so in three of the four periods. Morphine consumption was significantly higher in the SAB group during the first two periods but similar to the SFB group thereafter. CONCLUSION: In comparison with SAB, SFB resulted in superior analgesia and reduced morphine consumption for the first 24 hours following total knee arthroplasty.

Aged↗