[The effect of propranolol on basal and stimulated renin activity in patients with kidney transplantation].
Explore the source record for details and available documents.
Humans↗
Biomedical subjects
J Furrer
Publications and source records attributed to J Furrer.
In vivo effects of angiotensin antagonists on plasma aldosterone in the dog.
The effects of infusions of equimolar doses of Sar1-Ile8-angiotensin II and of Sar1-Ala8-angiotensin II on plasma aldosterone, plasma renin activity and arterial blood pressure were compared in normal dogs. Plasma aldosterone increased significantly after Sar1-Ile8-angiotensin II whereas it was unaffected by Sar1-Ala8-angiotensin II. Changes in blood pressure and renin activity were small without marked differences between both groups of animals. The experiments demonstrate a clear steroidogenic potency of Sar1-Ile8-angiotensin II. Therefore, Sar1-Ala8-angiotensin II should be preferred as antagonist of the action of angiotensin II in the adrenal gland.
Adrenal Cortex Hormones↗
Multistep synthesis of 2,5-diketopiperazines on different solid supports monitored by high resolution magic angle spinning NMR spectroscopy.
The solid-phase synthesis of 2,5-diketopiperazines containing the trans-4-hydroxy-L-proline amino acid residue (Hyp) was performed on Ellman polystyrene, polyoxyethylene-polyoxypropylene (POEPOP), polystyrene-polyoxyethylene NovaSyn, and Wang resins, respectively. The reaction pathway allowed the introduction of different functional groups around the bicyclic scaffold in a combinatorial approach, and it generated mixtures of isomers. A detailed characterization of the single reaction steps by high resolution magic angle spinning (HRMAS) NMR spectroscopy was performed. The NMR spectral resolution of the resin-bound intermediates and final products was greatly influenced by the polymer matrix. The POEPOP resin permitted to obtain HRMAS NMR spectra with a resolution comparable with that of the spectra of the molecules in solution. Moreover, configurational and conformational isomers formed during the solid-phase reaction steps could be detected and easily assigned. Therefore, the combination of the HRMAS NMR technique with the use of nonaromatic resins may become an extremely powerful tool in solid-phase organic synthesis. This approach will allow the monitoring of multistep reactions and the conception of on-bead structural studies either on small molecules or on natural and/or synthetic oligomers.
Journal Article↗
Skin capillary aneurysms detected by indocyanine green in type I diabetes with and without retinal microaneurysms.
Functional diabetic microangiopathy of skin vessels is well known (decreased reactivity of arterioles to various stimuli, increased capillary pressure and permeability). In contrast to conventional capillaroscopy, recently introduced infrared fluorescence videomicroscopy with indocyanine green allows one to depict capillary aneurysms, even when filled with plasma alone. Seventeen healthy volunteers (mean age 37.7 years), 14 patients with type I diabetes without (31.3 years) and 17 with retinal microaneurysms (46.8 years) were studied. The mean duration of diabetes in patients without retinal microaneurysms was 14.2 years (4-36 years) and in those with retinal microaneurysms 21.5 years (8-49 years). Nailfold capillary aneurysms were present in 3 of 17 healthy controls, in 7 of 14 patients without and in 10 of 17 patients with retinopathy. Patients with type I diabetes with and without retinopathy exhibited significantly more skin microaneurysms (p < 0.05 and < 0.005, respectively) than the controls. The prevalence in the patients with retinal microaneurysms tended to be even higher. Skin capillary aneurysms, which may be depicted in vivo by sophisticated infrared fluorescence videomicroscopy, even when filled by plasma alone, are an important morphological feature of diabetic microangiopathy.
Adult↗