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Biomedical subjects

J Fulton

Publications and source records attributed to J Fulton.

At least 37 records · Page 2Linked to original sources
PubMed1993

Public policy and funding issues. The role of the clinician from a Canadian perspective.

Radiologists and cardiologists may wish to consider an evolution of their roles: Begin to delegate some tasks to others so there is time to concentrate on the areas that are important in terms of the science of diagnosis. Train and empower technicians to do more; they are skilled and are capable of lightening the workload. It is important to offer outreach services to augment the training of other physicians. Many who work in referral and tertiary centers and teaching centers have a limited concept of what it is like to be in a center with limited technology. It is vital to know what is cost-effective and to promote those services. Physicians need media skills and ways to show other clinicians and consumers the importance of their work. It is also important to develop standards for the ordering of diagnostic procedures, to help referring physicians and young physicians to order effectively so that there is less need for policing. Evaluate new technology; informed physicians become partners in the choice and not the victim of the politics. Understand that the values about health care in Canada and the United States are changing. Have a flexible outlook. The world is changing very fast, and medicine needs to change with it. Innovate; try a new approach; take a risk. Continue to do what you already do best. Try to accept a share of social responsibility. If you really think inappropriate consumption of diagnostic services is occurring, try to deal with it. Cardiologists and radiologists have done innovative, creative things, and few people know about them because not everybody reads scientific journals.(ABSTRACT TRUNCATED AT 250 WORDS)

Canada↗
PubMed1983

Methylation of satellite DNA.

The lower amount of 5 methylcytosine in DNA from bull sperm relative to DNA of other bovine tissues is a result of the absence of this minor base from several of the satellite DNAs in sperm. This applies particularly to the 1.715, 1.711b and 1.709 satellites and less so to the 1.706 and 1.711a satellites. Mouse sperm DNA is also partially undermethylated.

Animals↗
PubMed1982

The effect of 5-azadeoxycytidine on cell growth and DNA methylation.

By growing cells in the presence of 3 mM thymidine and 5-azadeoxycytidine up to 20% of DNA cytosines have been substituted with azacytosine. No substitution was obtained on incubating with 5-methyldeoxycytidine. Azacytosine-substituted DNA has a very low level of 5-methylcytosine and cells, which survive azadeoxycytidine treatments maintain this low level of methylation in the absence of the drug. The DNA of such cells is undermethylated fairly evenly in all classes of DNA e.g., satellite and unique DNA. Incubation of cells in azadeoxycytidine leads to high cell mortality which is not related to the lack of DNA methylation but may be linked to the altered interactions of proteins with the substituted DNA. This effect, rather than reduced DNA methylation, may be the cause of differentiative changes observed on treatment of cells with 5-azacytidine.

Animals↗
PubMed1975

Effects of retinoic acid on prostaglandin biosynthesis in guinea-pig skin.

Topical application of retinoic acid on guinea-pig skin resulted within 70 hours in erythema with a concomitant elevation of endogenous prostaglandin E2 (PGE2) in the treated areas of the skin. Prolonged daily treatment resulted in the development of severe scaly dermatoses and a corresponding decrease in the level of PGE2 in the skin. Examination of retinoic acid effects on the in vitro biosynthesis of PGE2 from arachidonic acid by extracts from guinea-pig skin and sheep vesicular gland demonstrated that retinoic acid inhibits prostaglandin synthesis in a concentration and time-dependent manner. These results indicate that retinoic acid may exert a regulatory role on prostaglandin biosynthesis in the skin.

Animals↗
PubMed1965

Penicillin sensitivity.

The results obtained in this study indicate that there are various patterns of hypersensitivity to penicillin. In order to detect these variations it is suggested that two antigens, penicillin and penicilloyl-polylysine, be employed to test for both serum and skin sensitivity. Absolutely accurate predictions cannot be made from these tests, but it is felt that their use will minimize untoward reactions of the anaphylactic type in patients thus screened for penicillin allergy.

Drug Hypersensitivity↗
PubMedDate not supplied

The Graduate Record Examination as an admission requirement for the graduate nursing program.

The use of the Graduate Record Examination (GRE) as an admission criterion for the master's degree program was evaluated using data from student records of the population that graduated or dropped out of the State University of New York at Buffalo program between 1983 and 1992. The GRE correlated with first-year and overall graduate grade point averages, but it was a weaker predictor of performance than was the undergraduate grade point average. These findings are discussed in light of the negative consequences of using the GRE related to the recruitment of minority students, women, and older students.

Adult↗