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Biomedical subjects

J Fujii

Publications and source records attributed to J Fujii.

384 records · Page 22Linked to original sources
PubMedDate not supplied

Norepinephrine turnover in the cardiovascular tissues and brain stem of the rabbit during development of one-kidney and two-kidney Goldblatt hypertension.

To assess the role of the sympathetic and central noradrenergic neurons in one- and two- kidney Goldblatt hypertension, we examined the concentration and turnover of norepinephrine (NE) in the aorta, mesenteric artery, left ventricle, hypothalamus, midbrain, and pons medulla of hypertensive and control rabbits. Animals were made hypertensive by constriction of the left renal artery after right nephrectomy (1KGH group) or with the right kidney left intact (2KGH group), or were sham-operated on the renal artery (1KGC and 2KGC groups). At 14 days after the constriction, the blood pressure was increased to 136 +/- 3 mm Hg in the 1KGH vs 98 +/- 3 mm Hg in the 1KGC (p less than 0.001), and 136 +/- 2 mm Hg in the 2KGH vs 94 +/- 2 mm Hg in the 2KGC group (p less than 0.001). Turnover time in the aorta, mesenteric artery, and left ventricle in the 1KGH group was decreased to 47%, 45%, and 65% of that in the 1KGC group, respectively. Results suggest that enhanced sympathetic neuron activity in the cardiovascular system, especially in the arteries, contributes to the development of one-kidney Goldblatt hypertension. Norepinephrine turnover in the cardiovascular tissues in the 2KGH group and in the brain stem in the 1KGH and 2KGH group was not different from that in the control group.

Animals↗
PubMedDate not supplied

Effect of high and low sodium intake on norepinephrine turnover in the cardiovascular tissues and brain stem of the rabbit.

To assess the relationship between sympathetic nerve function and sodium intake, we examined norepinephrine (NE) turnover in several cardiovascular tissues and the brain stem of rabbits maintained for 3 weeks on high (86 mEQ), normal (14 mEQ), and low (0.2 mEQ/day) sodium diet. None of the diets changed the blood pressure significantly. Plasma renin activity became high in the low sodium group and low in the high sodium group at the end of the treatment. NE turnover was measured from the rate of decline of tissue NE concentration after administration of alpha-methyl-p-tyrosine. Variation of sodium intake exerted opposite effects on NE turnover in the periphery and in the central nervous system; increasing sodium intake caused an increase in NE turnover in the thoracic aorta, mesenteric vein, and left ventricle, and a decrease in the hypothalamus, midbrain, and pons medulla. But in the mesenteric vein, and left ventricle, and a decrease in the hypothalamus, midbrain, and pons medulla. But in the mesenteric artery and abdominal aorta it was not affected by dietary sodium manipulation. The results show the varying influence of sodium balance on the central and peripheral noradrenergic neuron activity.

Adrenergic Fibers↗
PubMedDate not supplied

Legionella infection and control in occupational and environmental health.

This review describes the microbiological characteristics of Legionella species, their habits in the environment, source and route of infection, pathogenesis, symptoms and treatment of legionellosis, and disease outbreaks worldwide. We also describe prevention measures to deal with this organism in the work environment. Particularly in Japan, the present measures and countermeasures against legionellosis are inadequate when compared with those Europe and the United States because occupational and environmental medicine in Japan has not been structured from a microbiological viewpoint. As a result, workplace inspections have not covered cooling towers. We surveyed the cooling towers provided in work environments and in hospitals in Kitakyushu City for contamination by Legionella species. The surveillance definitely revealed that we are surrounded by cooling towers contaminated with Legionella. We conclude that in Japan, occupational and environmental physicians should routinely monitor the water in cooling towers.

Humans↗