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Biomedical subjects

J Fujii

Publications and source records attributed to J Fujii.

At least 289 records · Page 16Linked to original sources
PubMed1982

Experimental production of papillary muscle and mitral valve lesions by vagal manipulations in rabbits.

The present paper describes peculiar lesions in papillary muscles and mitral valves produced by vagal manipulations. In the 109 rabbits killed one week after clipping or crushing of their cervical vagi, papillary muscle and mitral valve lesions were found in 53 (48.6%) and 52 (47.7%) hearts respectively. The lesions were identified by visible deposits of colloidal carbon which had been injected intravenously during the first 3 postoperative days. The left ventricular free wall, interventricular septum and right ventricle were free of carbon deposits. The papillary muscles involved were characterized by swelling and increased stiffness which corresponded to degeneration of the myocardial cells and interstitial fibrosis on microscopic observation. Hydroxyproline content of the papillary muscles involved was 1.4 times more than that of normal hearts, while there was no significant difference in hydroxyproline content of either interventricular septum or left ventricular free wall between the manipulated and the normal preparations. Heart murmurs were heard in 23 animals studied. Phonocardiograms revealed mid to late systolic murmurs with or without midsystolic click. These results indicate that the vagus nerve plays an important role in the pathogenesis of some forms of papillary muscle and mitral valve lesions.

Animals↗
PubMed1982

Evaluation of the left ventricular function in aortic regurgitation by echocardiography and indicator dilution method.

The left ventricular function and severity of LV volume overload were assessed in 30 patients with aortic regurgitation by a combined use of echocardiography and indicator dilution method. With decreasing functional capacity of patients, there tended to be greater increase in EDV, and decreases in CO, EF, Vcf, and BAP(DN)/ESV, and shift of LV function curve downward and to the right, reflecting LV myocardial dysfunction. There was a substantial correlation between functional capacity and the severity of regurgitation as well as LV myocardial function, suggesting the possibility that clinical symptoms may depend upon both the myocardial function and severity of aortic regurgitation. In contrast with many patients with AR of functional class I or II, who had relatively normal LV function, the patients of class III consistently showed substantial LV myocardial dysfunction. After sublingual administration of ISDN, BAP lowered, EDV and RF decreased. Lowering of BAP and RF were more prominent in class III than in class I. It has been proved that a combined use of echocardiography and indicator dilution method is of value in assessing the left ventricular function and regurgitant fraction in patients with aortic regurgitation, allowing a better understanding of the disease process and the potential for recognizing patients who may require early valve replacement.

Aged↗
PubMed1982

Left atrial enlargement in patients with paroxysmal atrial fibrillation.

The present study was designed to examine whether the left atrium is dilated in paroxysmal atrial fibrillation or not. Left atrial dimension (LAD) on M-mode echocardiogram was (1) 23.3 +/- 0.7 mm (mean +/- S.E.) in 24 normal subjects, (2) 30.5 +/- 0.7 mm in 58 patients without atrial fibrillation who had hypertension and/or ischemic heart disease, (3) 35.5 +/- 0.9 mm in 27 patients with paroxysmal atrial fibrillation of whom 23 had non-rheumatic cardiovascular diseases and 4 had idiopathic atrial fibrillation, (4) 40.5 +/- 1.1 mm in 38 patients with persistent atrial fibrillation of whom 30 had nonrheumatic cardiovascular diseases and 8 had idiopathic atrial fibrillation, and (5) 53.3 +/- 2.0 mm in 17 patients with persistent atrial fibrillation who had rheumatic heart disease. LAD showed a stepwise and significant increase from the first to the fifth group. LAD of patients with paroxysmal atrial fibrillation was not related to either the number or duration of paroxysms. These results indicate that the left atrium is slightly dilated in patients with paroxysmal atrial fibrillation.

Adult↗
PubMed1982

[Evaluation of regional wall motion of the left ventricle before and after nitroglycerin administration in patients with ischemic heart disease: comparison between two-dimensional echocardiograms and coronary angiograms].

Effects of nitroglycerin (NTG) on segmental wall motion and pump function of the left ventricle (LV) were studied in 19 patients with ischemic heart disease (IHD) and 10 normal controls by two-dimensional echocardiography (2DE) and coronary arteriography (CAG). Short-axis cross-sectional images of the LV at the mitral valve, papillary muscles and the apex were recorded and subdivided into quadrants at each level. The center of gravity of the end-diastolic LV cavity and the axis intersecting this point and the right side of the posterior end of the interventricular septum were used as the reference point and line. The areas of whole sections and of each quadrant at end-diastole (Ad) and end-systole (As) were measured by the computer. Regional contractility and pump function of the LV were evaluated by (Ad-As)/Ad and (Ad-As) of quadrants and sections. The results were as follows: Blood pressure (BP), Ad and (Ad-As) of sections significantly decreased after NTG administration. (Ad-As)/Ad of the sections with normal wall motion showed no significant change after NTG. (Ad-As)/Ad of the quadrants with hypokinetic segmental wall motion showed a tendency to increase after NTG in contrast with the normal quadrants which showed no significant change. CAG findings and hemodynamic parameters in patients who showed a significant increase in (Ad-As)/Ad of all sections after NTG (Gr. I) were compared with those in patients who showed a decrease in (Ad-As)/Ad of all sections (Gr. II). There was no significant correlation between CAG findings in Gr. I and Gr. II. The only difference between these two groups before NTG was that mean Ad of sections in Gr. I was significantly greater than that of Gr. II. After NTG, Gr. I showed a significant decrease of BP, but Gr. II did not show any significant change. (Ad-As) of sections in Gr. I increased or showed no change after NTG, but those in Gr. II decreased. In conclusion, NTG can reverse wall motion asynergy, especially in hypokinetic segments, and produce favorable changes in pump function in patients with increased Ad before NTG. The mechanism of NTG to improve wall motion and pump function is considered to be afterload and preload reduction.

Blood Pressure↗
PubMed1982

[Computer analysis of wo-dimensional echocardiogram for the quantitative evaluation of left ventricular asynergy in myocardial infarction].

Quantitative assessment of left ventricular asynergy in myocardial infarction was made by computer analysis of the two-dimensional echocardiogram. Short-axis cross-sectional images of the left ventricle at the levels of the mitral valve, papillary muscle and apex were recorded by a phased array sector scanner in 20 patients with myocardial infarction and ten normal controls. End cardial and epicardial outlines at end-diastole and end-systole were traced and analyzed by a computer system. Short-axis cross-sectional images of the left ventricle were divided equally into octants and analyzed with a fixed external reference system, using the center of gravity of end-diastolic left ventricular cavity and the axis intersecting this and the right side of the posterior interventricular septum as the reference point and line. Segmental hemiaxis, area, wall thickness and those changes during cardiac cycle were measured and calculated in each octants. Regional contractility of the left ventricle was evaluated by systolic percent change of segmental hemiaxis, area and wall thickness. These parameters were significantly reduced in the infarcted segments documented by left ventriculography and electrocardiography. The area method is better than the hemiaxis system in both reproducibility and variability. The center of gravity of the left ventricular cavity determined by the computer shifted slightly towards the anterior wall during systole in normal subjects, possibly reflecting anterior swinging motion of the entire heart. The center of the gravity of the left ventricular cavity in myocardial infarction showed the tendency to shift towards the infarcted region, suggesting the possibility that the location of asynergic area can be detected by determining the direction of the gravity center shift during systole in patients with a single infarction. This finding gives a basis of using the fixed reference system for the detection of asynergy. The use of computers for the analysis of short-axis two-dimensional echocardiographic images is very useful for the quantification of regional contractility of the left ventricle in a clinical setting.

Computers↗
PubMed1981

Pseudo right atrial overloading pattern in complete defect of the left pericardium.

Two cases with complete defect of the left pericardium showing tall and peaked P waves in the right precordial leads are described. A review of the literature has yielded nine cases with uncomplicated complete defect of the left pericardium showing similar P wave changes. Right heart catheterization, performed in nine cases, including the present two cases, revealed no evidence of an intracardiac shunt in any case and normal intracardiac pressure in eight cases. Therefore, this P wave changes seems to be related to intrathoracic shift in cardiac position permitted by the absence of the restraining pericardium.

Adult↗
PubMed1981

Studies on the structures of the carbohydrate moiety of human prothrombin.

Human prothrombin contains three asparagine-linked sugar chains in one molecule. The sugar chains were quantitatively liberated as radioactive oligosaccharides from the polypeptide moiety by hydrazinolysis followed by N-acetylation and Nab3H4 reduction. All of the oligosaccharides contain N-acetylneuraminic acid. The neutral oligosaccharides obtained from all acidic oligosaccharides by sialidase digestion are identical. By the combination of sequential exoglycosidase digestion and methylation analysis, the structures of the asparagine-linked sugar chains of human prothrombin were confirmed to be as follows: (sequence in text).

Carbohydrate Sequence↗
PubMed1981

Experimental production of poststenotic dilatation in the carotid arteries of rabbits.

Arterial dilatation distal to a stenosis has been known as poststenotic dilatation (PSD). This paper describes arterial constriction enough to produce PSD, time course of PSD, structural changes of the dilated segments and influence of hypertension on the development of PSD. These problems were studied in 2 experimental protocols. In protocol I, 87 carotid arteries of 45 rabbits were constricted by silver clip of 0.65 to 2.0 mm in diameter. The arterial diameter was measured at the sites both proximal and distal to the constriction after 3 days to 8 weeks. In protocol II, 22 carotid arteries of 12 rabbits with experimental one-or two-kidney Goldblatt hypertension were constricted and the development of PSD was compared with age matched controls. Remarkable PSD developed in arteries with moderate stenosis of 45 to 60% constriction. The degree of dilatation expressed as ratio of distal to proximal diameter reached about 1.5 at the end of the second week and remained unchanged thereafter. Destruction of the elastic fibers with intimal hyperplasia was observed in the dilated segments even at the early stages of the PSD. Both mild and severe stenosis failed to produce prominent PSD. In protocol II, the PSD averaged 1.18 +/- 0.05 (mean +/- SE) in hypertensive, and 1.32 +/- 0.03 in normotensive animals (p less than 0.05). The result suggests that chronic hypertension decreases the distensibility of the arteries.

Animals↗
PubMed1981

Clinical features of paroxysmal atrial fibrillation. An observation of 94 patients.

During the past 10 years we experienced 234 patients with atrial fibrillation of whom 94 patients (40.2%) showed a paroxysmal form. Underlying diseases of these 94 patients were hypertension and/or coronary heart disease in 51 (54.3%), rheumatic valvular disease in 3 (3.2%), hyperthyroidism in 2 (2.1%), and miscellaneous diseases in 15 patients (16.0%). Idiopathic atrial fibrillation was found in the remaining 23 patients (24.5%). Frequency of paroxysm was variable. paroxysm occurred only once or twice in 35 patients (37.2%) and more than 21 times in 20 patients (21.3%). Duration of a single paroxysm ranged from less than 24 hours in 49 patients (52.1%) to more than 15 days in 7 patients (7.4%). Atrial fibrillation became permanent in 19 (25.3%) of 75 patients who had been observed for a period of more than 1 year.

Adult↗
PubMed1981

Elevation of serum creatine phosphokinase during pindolol treatment.

We observed elevation of serum CPK in hypertensive patients under pindolol treatment. In this report, we showed a representative patient and compared serum CPK values in 56 patients under pindolol treatment to those in 64 patients under propranolol treatment. Mean serum CPK values in the patients under pindolol treatment and propranolol treatment were 117.0 +/- 12.6 (S.E.) and 50.8 +/- 3.8 IU/liter, respectively (p less than 0.01). Although the mechanism of elevation of serum CPK cannot be well understood, we should be careful in clinical evaluation of serum CPK during pindolol treatment.

Creatine Kinase↗
PubMed1981

[Studies of interventricular septal motion after heart valve replacement by two-dimensional echocardiography and thallium 201 scintigraphy (author's transl)].

Etiology of abnormal interventricular septal motion detected by M-mode echocardiography after heart valve replacement was studied by two-dimensional echocardiography and thallium 201 scintigraphy in three patients with valvular heart disease (two with mitral regurgitation, and one with aortic regurgitation). M-mode and two-dimensional echocardiograms were recorded before and after heart valve replacement, using Aloka SSD-800. After intravenous injection of 2.0 mCi of ionic thallium 201, myocardial images were recorded with a scintillation camera (Searle PHO Gamma V) with converging collimator. Abnormal interventricular septal motion (systolic anterior motion) was observed echocardiographically in all of three patients after mitral or aortic valve replacement. Two-dimensional echocardiogram showed systolic anterior motion of the whole heart towards the anterior chest wall, though the left ventricle itself contracted normally. Thallium 201 scintigram showed no significant perfusion defects of the left ventricular wall including ventricular septum. No findings showing conduction disturbance, right ventricular volume overload or pericardial effusion were observed after heart valve replacement.

Adult↗
PubMed1981

[Digital image processing of the two-dimensional echocardiogram for the evaluation of regional contractility of the left ventricular wall (author's transl)].

Short-axis cross-sectional images of the left ventricle at the levels of the mitral valve, papillary muscles and apex were recorded on video tape by using a phased-array sector scanner. Endocardial and epicardial outlines of the cross-sectional left ventricular wall were determined automatically by a computer tracing process including digital image processing system. Short axis cross-sectional left ventricular walls of upper-, middle- and lower parts of the left ventricle were divided into eight segments, the center of gravity of end-diastolic left ventricular cavity being used as the reference point. Various parameters such as segmental radius, segmental wall thickness, cross-sectional area, left ventricular circumference and those changes during the cardiac cycle were determined in eight segments at three levels of the left ventricle. Regional contractility of the left ventricular wall was evaluated by systolic shortening of segmental radius and systolic thickening of segmental wall thickness. Contractility and pumping function of the overall left ventricle was assessed by shortening velocity of left ventricular circumference and fractional changes of cross-sectional area at three levels of the left ventricle. These were significantly and diffusely reduced in a patient with congestive cardiomyopathy (CCM), contrasting with a normal subject. Systolic changes in segmental radius and segmental wall thickness were significantly reduced in infarcted myocardium. Digital image processing system and segmental analysis of the left ventricular short-axis two-dimensional echocardiogram are very useful to evaluate the regional contractility of the left ventricle, quantitatively and automatically, especially in patients with myocardial disease including CCM and myocardial infarction with left ventricular asynergy.

Computers↗