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J Fritze

Publications and source records attributed to J Fritze.

At least 109 records · Page 6Linked to original sources
PubMed1990

Puerperal and cycloid psychoses. Results of a retrospective study.

Puerperal psychoses are traditionally considered to be nosologically unspecific. They are defined exclusively by their occurrence close to delivery. Attempts to further diagnostically subdivide puerperal psychoses have been prevented to date by the influence of Kraepelin's dichotomy. New possibilities of nosological differentiation arose out of Kasanin's (1933) description of schizoaffective psychoses and out of Leonhard's differentiated nosology (1986). The objective of the present, retrospective study was to apply Leonhard's nosology to 42 postpartal psychoses. Five diagnostic groups could be identified: 6 cases of manic-depressive disorder, 7 cases of pure depression, 8 cases of pure melancholia, 2 cases of unsystematic schizophrenia, and 19 cases of cycloid psychoses. For this reason we consider that the concept of the cycloid psychoses is appropriate for the characterization of a large proportion of childbed psychoses.

Adult↗
PubMed1990

Schedule for operationalized diagnosis according to the Leonhard classification of endogenous psychoses.

Psychiatric diagnoses in endogenous psychoses are still largely based on clinical psychopathology. Despite intensive efforts including progress to more reliability in classification, no definite and causally relevant biological abnormalities have been identified so far. This failure might be due to the present standard classification systems like DSM or ICD being too crude to allow the distinction of homogeneous nosological entities. The classification developed by K. Leonhard offers a more subtle alternative. In order to facilitate the handling of this system and in the interest of reliability, an algorithm for computer-assisted diagnostic decision making based on similarities to Leonhard's ideal types is presented.

Bipolar Disorder↗
PubMed1989

Isoelectric focusing of monoamine oxidase subtypes as identified by MAO inhibitors.

Monoamine oxidase from various human tissues from several individuals was labeled with [3H]pargyline and solubilized by means of Triton X-100 or Triton X-100 and urea. The specificity of the labeling was assessed using various selective, reversible and irreversible inhibitors as pharmacologic tools in competition experiments. The labeled material was submitted to isoelectric focusing on polyacrylamide gels according to one- and two-dimensional electrophoretic procedures and with fluorographic detection. While the differences in electrophoretic mobility of the two subtypes, MAO-A and MAO-B, could be replicated the subtypes showed identical although heterogeneous charges in isoelectric focusing. This contrasts with recent findings of clear differences in the primary structure of monoamine oxidase subtypes and thus needs further clarification.

Adult↗
PubMed1989

Plasma moclobemide and metabolites: lack of correlation with clinical response and biogenic amines.

The concentration of the reversible monoamine oxidase type-A (MAO-A) inhibitor moclobemide (Ro 11-1163) was determined by high pressure liquid chromatography (HPLC) in the plasma of 16 depressives treated with moclobemide. Moreover, the inhibitory potency of organic extracts of the plasma on a standard MAO-A preparation from human placenta was measured spectrophotometrically. The inhibitory potency significantly correlated with the HPLC results. However, it overestimated the concentration of moclobemide by one order of magnitude possibly due to the presence of yet unknown metabolites more active than moclobemide itself. These have already been suggested in view of the higher inhibitory potency of moclobemide ex vivo than in vitro. This new methodological approach might represent a comfortable alternative to HPLC procedures in pharmacokinetic studies on reversible MAO inhibitors. Plasma biogenic amines and their metabolites might be indicative of the biologic activity of moclobemide. Plasma homovanillic acid (HVA) decreased and norepinephrine (NE) increased under moclobemide, although insignificantly. There was no significant correlation between the plasma concentration of moclobemide as estimated by either method and the therapeutic response and the change of plasma HVA and NE.

Adult↗
PubMed1989

Effect of antemortem and postmortem factors on [3H]MK-801 binding in the human brain: transient elevation during early childhood.

The effect of a number of antemortem and postmortem factors on [3H]MK-801 binding was investigated under equilibrium conditions in the frontal cortex of human brains of 38 controls. Binding values transiently increased during the early postnatal period reaching a maximum at the age of about 2 years. After age 10 years [3H]MK-801 binding sites disappeared at 5.7% per decade. The storage time of brain tissue had a reducing effect on these binding sites. There was no effect of gender, brain weight or postmortem time interval and the binding sites were bilaterally symmetrically distributed in the frontal cortex.

Age Factors↗
PubMed1989

Demonstration of monoamine oxidase-A and -B in the human brainstem by a histochemical technique.

The distribution of both monoamine oxidase subtypes, monoamine oxidase-A and -B, is demonstrated in brainstems from 16 humans by use of a histochemical technique. The results presented here, focus primarily upon the aminergic areas of the substantia nigra, the locus coeruleus and the raphe nuclei. While dopaminergic neurons of the substantia nigra revealed no staining for monoamine oxidase, noradrenergic neurons of the locus coeruleus stained positively with the monoamine oxidase-A substrate serotonin, and serotonergic neurons of the raphe nuclei were stained by the monoamine oxidase-B substrate beta-phenylethylamine. In addition, data are presented showing that glial cells stain predominantly for monoamine oxidase-B.

Adolescent↗
PubMed1988

Effect of antemortem and postmortem factors on [3H]glutamate binding in the human brain.

The effect of a number of antemortem and postmortem factors on both N-methyl-D-aspartate (NMDA) sensitive and NMDA insensitive [3H]glutamate binding was investigated in the frontal cortex and putamen of human brains. There was a high correlation between both binding sites (r = 0.86, P less than 0.001) and both binding sites increased during the early postnatal period reaching a maximum between age 1 and 2 years. After age 10 years NMDA sensitive sites disappeared at 9.2% per decade while the NMDA insensitive sites disappeared at 7.4% per decade only. Therefore, the ratio between NMDA sensitive and NMDA insensitive sites changed in favor of the NMDA insensitive site with increasing age. The storage time of brain tissue had a strong reducing effect on both binding sites, again affecting the NMDA sensitive sites more severely. There was no obvious effect of gender, brain weight or postmortem time interval on either binding site. Furthermore, there was no difference between frontal cortex and putamen. Both binding sites were bilateral symmetrically distributed in either frontal cortex and putamen.

Adolescent↗
PubMed1988

Endocrine parameters and biogenic amines in relationship to psychopathology after cholinergic drug challenge (RS-86).

The centrally active muscarinic agonist RS-86 elicited a dose-dependent anergic-anhedonic syndrome in a double-blind dose-response study in one healthy volunteer. At 4 and 5 mg, RS-86 induced escape from cortisol suppression by dexamethasone parallel to an increase in prolactin. The time course, as well as the absence of increases in plasma epinephrine and growth hormone, suggests that the changes are not due to nonspecific stress. However, there was a slight increase in plasma norepinephrine, tentatively dependent on the dose of RS-86. In 12-hour urine samples the excretion of 3-methoxy-4-hydroxy-phenylglycol and homovanillic acid tended to decrease in a dose-dependent manner, with a subsequent increase during the following nights. No systematic changes occurred in plasma dopamine, serotonin, and cyclic adenosine monophosphate or in plasma and urinary 3,4-dihydroxyphenylacetic acid or urinary vanillylmandelic acid. The findings are discussed in terms of the cholinergic-adrenergic balance hypothesis of affective disorders and biochemical findings in major depression.

Adult↗
PubMed1988

[The cholinergic-adrenergic equilibrium hypothesis of affective psychoses].

The biochemical effects of antidepressant drugs generated the hypothesis of disturbances in the noradrenergic system in the pathogenesis of affective disorders. However, interference with the cholinergic system also yields psychotropic sequelae. Central cholinomimetics revealed antimanic properties as opposed to antidepressant effects of anticholinergics. Therefore, in extension of the catecholamine hypothesis and again based on the paradigm of pharmacological isomorphism, a cholinergic-adrenergic balance hypothesis has been suggested for affective disorders. This postulates a cholinergic predominance relative to noradrenergic activity in depression and the converse in mania. Although there are indications of inverse behavioural effects of cholinergic as opposed to catecholaminergic stimulation in man and animal, there is only few evidence at the neurophysiological and biochemical level in favour of the net effects depending on such a balance. However, only the direct demonstration of a biochemical defect can prove the balance hypothesis. More probably, interindividually different defects must be expected. They need not necessarily involve the synaptic signal transduction directly. Strategies and findings which might demonstrate biochemical disturbances are presented and discussed.

Affective Disorders, Psychotic↗
PubMed1988

Reflection of central aminergic-cholinergic imbalance by peripheral enzymes in psychiatric disorders?

Disturbances of central catecholaminergic-cholinergic balances have been discussed as causing affective disorders and schizophrenia. Such imbalances might be due to abnormalities of the metabolizing enzymes, especially their activities relative to each other. With this in mind, the activities of platelet monoamine oxidase and plasma butyrylcholinesterase (pseudocholinesterase) were determined spectrophotometrically in 33 psychiatric patients and eight controls. No significant differences could be detected for the enzyme activities as such and their relationship as expressed by their ratios. Thus, these peripheral enzymes seem to be unlikely indicators of supposed central imbalances.

Adult↗