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Biomedical subjects

J Friedberg

Publications and source records attributed to J Friedberg.

52 records · Page 3Linked to original sources
PubMed1980

Tympanoplasty in childhood.

Seventy cases of tympanoplasty in children in whom disease appeared to be limited to the mesotympanum were reviewed. Careful pre-operative selection is recommended; however, the surgery itself presented no particular problems. Success in closure of the perforation and improvement in hearing is comparable to adult studies.

Adipose Tissue↗
PubMed1977

Shock treatment, brain damage, and memory loss: a neurological perspective.

The author reviews reports of neuropathology resulting from electroconvulsive therapy in experimental animals and humans. Although findings of petechial hemorrhage, gliosis, and neuronal loss were well established in the decade following the introduction of ECT, they have been generally ignored since then. ECT produces characteristic EEG changes and severe retrograde amnesia, as well as other more subtle effects on memory and learning. The author concludes that ECT results in brain disease and questions whether doctors should offer brain damage to their patients.

Amnesia, Retrograde↗
PubMed1977

Correction of congenital meatal atresia of the ear, utilizing a superiorly based post-auricular pedicle flap.

A technique for correction of congenital meatal atresia of the ear using a superiorly based post-auricular skin pedicle is presented. Once the bony meatus has been created and middle ear work completed, this flap may be transposed into the defect and it will provide sufficient skin to fully line all raw areas. This provides rapid healing and thus far, out of seven cases, no stenosis or longterm cavity problems have developed.

Ear Canal↗
PubMed1976

Xeroradiography in the assessment of the pediatric larynx and trachea.

Xeroradiography is a newer technique of radiologic imaging which provides both a wide recording latitude and the phenomenon of edge enhancement. It is the phenomenon of edge enhancement in particular which allows for excellent imaging of mucous membrane anatomy and abnormalities. The purpose of this presentation is to demonstrate the role of xeroradiography in the assessment of the pediatric larynx and trachea, with particular reference to the evaluation of tracheal stenosis.

Abscess↗
PubMedDate not supplied

Traumatic bronchial injuries in children.

Between 1975 and 1981 five children (three girls and two boys) from 3 to 11 years were treated for blunt chest trauma with major tears in two areas of the right main bronchus. All were hit or run over by motor vehicles and were in acute respiratory distress. All suffered right pneumothoraces; three did not respond to a chest tube with suction. Four of five children had subcutaneous emphysema, and two had fractured ribs on the ipsilateral side; three children also had contralateral chest injuries. Four had major extrathoracic injuries. Three children required early repair, while two needed late treatment. All five patients recovered well and have remained healthy from 5 to 10 years after injury. These cases serve as illustrations for a review of a survey of the literature.

Bronchi↗
PubMedDate not supplied

Discontinuing antidepressant treatment in major depression.

Maintenance treatments in bipolar disorders and schizophrenia are securely established, and their discontinuation is associated with high but modifiable risk of early relapse. The benefits of long-term antidepressant treatment in major depression and the risks of discontinuing medication at various times after clinical recovery from acute depression are not as well defined. Computerized searching found 27 studies with data on depression risk over time including a total of 3037 depressive patients treated for 5.78 (0-48) months and then followed for 16.6 (5-66) months with antidepressants continued or discontinued. Compared with patients whose antidepressants were discontinued, those with continued treatment showed much lower relapse rates (1.85 vs. 6.24%/month), longer time to 50% relapse (48.0 vs. 14.2 months), and lower 12-month relapse risk (19.5 vs. 44.8%) (all p < 0.001). However, longer prior treatment did not yield lower postdiscontinuation relapse risk, and differences in relapses off versus on antidepressants fell markedly with longer follow-up. Contrary to prediction, gradual discontinuation (dose-tapering or use of long-acting agents) did not yield lower relapse rates. Relapse risk was not associated with diagnostic criteria. More previous illness (particularly three or more prior episodes or a chronic course) was strongly associated with higher relapse risk after discontinuation of antidepressants but had no effect on response to continued treatment; patients with infrequent prior illness showed only minor relapse differences between drug and placebo treatment.

Analysis of Variance↗