Antihypertensive therapy in patients with type 2 diabetes mellitus: focus on nephropathy.
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Albuminuria↗
Biomedical subjects
J Franke
Publications and source records attributed to J Franke.
[Bilateral and simultaneous quadriceps tendon rupture in secondary hyperparathyroidism. A case report].
A case of bilateral simultaneous rupture of the quadriceps tendon without significant trauma is presented. Generally there is an association with chronic metabolic disorders, such as chronic renal failure and secondary hyperparathyreoidism, as well as hormonal diseases. The ruptures appeared in a 34-year-old man with chronic renal failure and severe secondary hyperparathyreoidism. Etiology, diagnostic procedures and treatment in comparison with the international literature are described. We discuss the value of ultrasound screening as a diagnostical and follow-up tool.
Adult↗
Stress burnout and addiction.
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Burnout, Professional↗
A novel component involved in ubiquitination is required for development of Dictyostelium discoideum.
A novel component of the ubiquitination system, called NOSA, is essential for cellular differentiation in Dictyostelium discoideum. Disruption of nosA does not affect the growth rate but causes an arrest in development after the cells have aggregated. nosA contains seven exons and codes for a developmentally regulated 3.5-kb mRNA. The 125-kDa NOSA protein is present in the cytosol at constant levels during growth and development. The C-terminal region of NOSA has homology with ubiquitin fusion degradation protein-2 (UFD2) of Saccharomyces cerevisiae and putative homologs in Caenorhabditis elegans and humans. UFD2 is involved in the ubiquitin-mediated degradation of model substrates in which ubiquitin forms part of the translation product, but ufd2 mutants have no detected phenotype. In accord with the homology to UFD2, we found differences in the ubiquitination patterns between nosA mutants and their parental cell line. While general in vivo and in vitro ubiquitination is minimally affected, ubiquitination of individual proteins is altered throughout growth and development in nosA mutants. These findings suggest that events involving ubiquitination are critical for progression through the aggregate stage of the Dictyostelium life cycle.
Amino Acid Sequence↗
[Perforated diverticulum of the vermiform appendix].
Diverticulitis of the vermiform appendix is an often disregarded disease. Diagnosis follows after appendectomy due to inflammatory complications in the form of diverticulitis and appendicitis. Diverticula can also be found as a reason for complaints in histologically unaltered appendix or as an incidental finding. Diverticula of the vermiform appendix are classified as false (acquired) or true (congenital). We report on the case of a 57-year-old man with a perforated appendix diverticulum as reason for peritonitis and a paralytic ileus of the colon and small intestine.
Appendectomy↗
County medical societies connect with members online.
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Computer Communication Networks↗
Med Bytes.
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Computer Communication Networks↗
Be prepared.
Remember back when Medicaid was Medicaid and Medicare was Medicare? These state and federal programs, which respectively provide medical assistance to low-income families and health insurance for individuals with disabilities and the elderly, were complicated enough when they became law as part of the Social Security Act in 1965. Now we've added managed care to the mix.
Humans↗
Selection for spiral waves in the social amoebae Dictyostelium.
Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium. Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Herein we test the essential features of this prediction by comparing wave propagation in wild type and inhibitor mutants. We find that mutants rarely form spirals. The territory size of mutant strains is approximately 50 times smaller than wild type, and the mature fruiting bodies are smaller but otherwise normal. These results identify a mechanism for selecting one wave symmetry over another in an excitable system and suggest that the phosphodiesterase inhibitor may be under selection because it helps regulate territory size.
3',5'-Cyclic-AMP Phosphodiesterases↗