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Biomedical subjects

J Frank

Publications and source records attributed to J Frank.

At least 415 records · Page 23Linked to original sources
PubMed1977

Oral contraceptives and blood pressure.

Both cross-sectional and longitudinal analysis of data from 13,358 women showed that oral contraceptive use is associated with a slight but statistically significant (P lesser than .05) rise in mean blood pressure, which is reversible. The age-adjusted proportion of oral contraceptive users with a blood pressure over 140/90 mm Hg was about three times that on nonusers. These findings are caused by a uniform upward shift in the blood pressure distribution of oral contraceptive users compared to nonusers. Women continuing oral contraceptive use had no appreciably greater change in blood pressure between two visits than persistent nonusers. The clinical implications of a mild contraceptive-induced blood pressure elevation (systolic, 5 to 6 mm Hg; diastolic, 1 to 2 mm Hg) remain unsettled but disturbing.

Adolescent↗
PubMed1977

The 11q -- syndrome.

An eighth case of terminal deletion of the long arm of chromosome eleven (11q--) is reported to emphasize both the distinctive facies, but otherwise non-specific nature of this disorder, and the female preponderance of affected patients. Growth and mental retardation, congenital heart disease and telecanthus are the other most constant features. The authors' experience with 3 unrelated cases in less than 2 years suggests that this syndrome is underdiagnosed.

Chromosome Aberrations↗
PubMed1977

IR spectrophotometric assay of carbachol solutions.

Carbachol ophthalmic solutions can be assayed by evaporating a measured volume, dissolving the residue in methanol, and scanning the carbonyl stretching frequency in an IR spectrophotometer using a cell with calcium fluoride windows. Methylcellulose and other formulation vehicle components do not interfere. The method is stability indicating with respect to hydrolysis. It affords a recovery of 99.5+/-0.51% (RSD).

Carbachol↗
PubMed1977

Motif detection in quantum noise-limited electron micrographs by cross-correlation.

The use of cross-correlation to detect randomly positioned low-dose realizations of a motif in an image field is quantitatively evaluated. For both the bright- and dark-field cases, we derive theoretical expressions for the minimum dose allowing detection in terms of motif size, resolution, and contrast. Model computations on simulated low-dose images of a spherical virus particle give results that agree with our theoretical formulas and demonstrate the feasibility of this approach.

Microscopy, Electron↗
PubMed1977

The incidence of cervical cancer and duration of oral contraceptive use.

In a prospective study carried out on a cohort of 17,942 women belonging to the Kaiser Foundation Health Plan and living in suburban communities of the San Francisco Bay Area, a positive association was found between the incidence of cervical carcinoma and total duration of oral contraceptive use. The association was established while controlling for the effects of age, education, and selected infections. The association persists when incident cases of dysplasia are added to those of carcinoma. A further study, in which covariates relating to sexual behavior will also be taken into account, is in progress.

Adolescent↗
PubMed1977

[Sclerotic occlusion of venous bypass].

The case of a patient is presented in whom in the course of repeated vascular surgery a venous by-pass was prepared. Eighteen months after the operation a sclerotic plaque occluded the bypass. After successful de-obliteration the patient became free of complaints. A review of the pertaining literature is presented and the possible causal factors are discussed.

Arteriosclerosis Obliterans↗
PubMed1976

Preservation of cross-modal transfer of a rate discrimination in the bushbaby (Galago senegalensis) with lesions of posterior neocortex.

The effect of lesions of posterior neocortex was assessed, using a test method that permits the demonstration of cross-modal transfer in intact bushbabies. Eight bushbabies were trained to discriminate light flashes of 18/sec and 3/sec in a go-no-go shock-avoidance task. On completion of training, four bushbabies received lesions of posterior neocortex by aspiration. After 6 wk both lesion and intact animals were returned to training in the visual discrimination. On the day following criterion performance on the visual tests, auditory clicks off the same rate and contingencies were substituted and maintained to criterion. All eight bushbabies demonstrated rapid transfer and the lesion animals were not retarded as compared with intact subjects. The cross-modal transfer of a specific rate discrimination was thus preserved in the absence of posterior intersensory neocortex. The results are discussed in terms of a hypothetical subcortical system capable of the amodal coding of simple stimulus dimensions.

Animals↗
PubMed1975

Averaging of low exposure electron micrographs of non-periodic objects.

The investigation concerns the possibility of extending to non-periodic objects the low exposure averaging techniques recently proposed for non-destructive electron microscopy of periodic biological objects. Two methods are discussed which are based on cross-correlation and are in principle suited for solving this problem.

Microscopy, Electron↗