Search PubMed⌕ Search

Biomedical subjects

J Francis

Publications and source records attributed to J Francis.

At least 145 records · Page 8Linked to original sources
PubMed1977

Immunotherapy of bovine ocular squamous cell carcinomas.

Squamous cell carcinomas were collected from the eyes of cattle and saline phenol extracts of the tumours were prepared. The aqueous phase of the extract was used in studies on the immunotherapy of ocular squamous cell carcinomas in cattle. After a single intramuscular injection of the extract, regression and sometimes complete disappearance of eye tumours were observed in 39 of 46 carcinomas. Tumours as large as 4 X 5 cm regressed completely. Enhanced growth of tumours was noted in two of three cattle given multiple injections. Regressing tumours were examined histologically and regression appeared to be associated with a cell-mediated immune reaction. Spontaneous regression of a confirmed squamous cell carcinoma was observed in one animal. This spontaneous tumour in one of the larger domestic animals provides a useful experimental model for the study of tumour antigens.

Animals↗
PubMed1976

Bos taurus Y chromosome of Africander cattle and the development of improved breeds for the tropics.

The Africander has anatomical and other characteristics of an animal of approximately 3/4 Bos indicus heredity. The fact that these cattle carry the Bos taurus Y chromosome supports this view and indicates that the local cattle in South Africa would have been crossed with one or more Bos taurus bulls. Droughtmaster and Braford cattle retain the Bos indicus Y chromosome because Bos indicus instead of Bos taurus bulls were used to establish these taurindicus breeds. Contrary to some assumptions, an approximate tenfold increase in productivity of cattle was made during the 18th and 19th centuries due to improvements in disease control, nutrition and genetic improvement. What is now needed is the development of taurindicus breeds combining to the maximum possible extent the disease resistance and hardiness of Bos indicus with the early maturity and productivity of Bos taurus cattle. In addition, the ravages of disease and the seasonal variations of food supply need to be overcome in tropical areas.

Animals↗