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Biomedical subjects

J Fränken

Publications and source records attributed to J Fränken.

6 recordsLinked to original sources
PubMed1995

[Mycosis fungoides bullosa].

We report on a male patient with mycosis fungoides (MF) with blisters mainly occurring on clinically uninvolved skin. This rare association has to be differentiated from other bullous diseases of the skin. The clinical picture has been known since the end of the last century and has been described as mycosis fungoides bullosa. The pathomechanism, however, has not yet been exactly identified. The different clinical and histological features of the disease are discussed.

Aged↗
PubMed1995

Onychomatricoma.

BACKGROUND: Onychomatricoma is a rare benign tumor originating in the nail matrix. Only eight cases have been reported until now. OBJECTIVE: The clinical and histopathological features of this recently reported tumor will be described and its differential diagnoses outlined. A typical case of onychomatricoma is described in a 62-year-old white man. RESULTS: Clinically, onychomatricoma is characterized by: 1) a yellowish discoloration of a longitudinal segment of the nail plate with small splinter hemorrhages within the proximal portion of the nail; 2) a thickening with increased transversal curvature of the involved nail plate positively corresponding with the yellow discoloration; and 3) a matrix tumor consisting of multiple fine filiform projections that extend into the thickened nail plate. The treatment of onychomatricoma is complete excision of the tumor. CONCLUSION: Onychomatricoma is a new entity with clinical and histopathological features that are characteristic enough to make the correct diagnosis.

Diagnosis, Differential↗
PubMed1994

Identification of alpha-amylase inhibitor as a major allergen of wheat flour.

We isolated a major wheat flour allergen with a molecular weight of 15-kD. The 15-kD allergen was purified from an extract of wheat flour by ammonium sulfate precipitation followed by gel filtration. Using the immunoblot technique, IgE, specifically directed towards the single isolated allergen, was detectable in 50% of the applied sera. We determined the N-terminal amino acid sequence of the allergen and identified it as an alpha-amylase inhibitor protein. Our data emphasize that low molecular weight wheat flour allergens play an important role in the pathogenesis of baker's asthma disease.

Allergens↗
PubMed1991

Characterization of allergenic components of rye and wheat flour (Secale, Triticum vulgaris) by western blot with sera of bakers: their effects on CD23 expression.

The allergenic components of water-soluble rye flour extract were studied by immunoblotting. Sera from 100 bakers were analyzed for their IgG, IgG4 and IgE binding pattern. Two allergens with molecular weights of 35 and 14 kD were detected. Previously, the major allergens of wheat flour extract were identified. The wheat flour components at a MW of 15/17 kD and the rye flour component at a MW of 14 kD were purified and isolated. The modulation of the low affinity receptor for IgE (Fc epsilon RII/CD23) on monocytes by separated allergenic components was studied. Depending on the allergen concentration the CD23 expression on isolated cells increased after stimulation with the rye flour component (MW 14 kD). The combined addition of the rye flour component (14 kD) with IL-4 induced a significant CD23 expression as compared to IL-4 alone.

Allergens↗
PubMed1991

Staphylococcus aureus modifies the cytokine-induced immunoglobulin synthesis and CD23 expression in patients with atopic dermatitis.

The influence of Staphylococcus aureus on peripheral blood lymphocytes (PBL) of patients with atopic dermatitis (AD) was analysed. The parameters studied were spontaneous and interleukin-inducible immunoglobulin (IgA, IgE, IgG) synthesis, as well as CD23 expression. Various heat-killed, clinical isolates of S. aureus were analysed. PBL from non-atopic donors served as controls. The time-course of co-cultured PBL with S. aureus showed a dose-dependent increase in immunoglobulin (Ig) synthesis from PBL of normal donors, whereas the Ig synthesis of atopic cells was significantly depressed. Additional stimulation with interleukin-4 (IL-4) also led to a pronounced suppression of the IgE and IgA synthesis in normal donor cells, while the effect of S. aureus on PBL of atopic donors was not markedly affected by IL-4. Transwell cultures of bacteria separated from PBL by a semi-permeable membrane induced stimulation of IgA and IgE synthesis in patients with AD. The Ig synthesis in the control group was not altered. Co-stimulation of S. aureus and IL-4 in this system led to a suppression of IgA with cells of both atopic and normal donors. IgE synthesis from atopic PBL was significantly stimulated. The CD23 expression of atopic PBL was increased by S. aureus and IL-4. Our data indicate that S. aureus may modulate the cytokine-dependent humoral immunity in patients with AD and that chronic colonization of the skin may be responsible for allergic skin reactions in AD.

Antigens, Bacterial↗