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Biomedical subjects

J Fox

Publications and source records attributed to J Fox.

At least 307 records · Page 17Linked to original sources
PubMed1975

The use of structural diagnostics in recognition.

The suggestion of Krueger (1973) and other that wholistic processes underlie certain perceptual judgments is taken up in this paper. It is argued that properties such as bilateral symmetry can have a "diagnostic" significance for visual matching tasks. Diagnosticity means that if the property is present the appropriate response to a stimulus could theoretically be determined without any other analysis of the stimulus. Experiments 1 and 2 indicate that symmetry is exploited as a diagnostic property for the simultaneous same-different judgment. Displays that show the diagnostic form produce short reaction times. These experiments also show that the diagnosticity effect can be demonstrated independent of potentially confounding factors such as simplicity or redundancy. Experiments 3, 4, and 5 discount further confounding factors and also show that other properties, notably parallelism and colinearity of stimulus elements, can also be exploited as diagnostic in the simultaneous matching task. Diagnostics can have a structural or relational form. Diagnostic features are viewed as two-place structural predicates. Whether these diagnostics always have the same underlying form or not, the need for some representation of structure is a prerequisite for understanding even these simple recognition phenomena.

Association↗
PubMed1973

Biological availability of digoxin from Lanoxin produced in the United Kingdom.

Though established quality control standards were maintained, the bioavailability of digoxin from Lanoxin tablets produced in the United Kingdom fell in 1969, and was restored in 1972. After 1.5 mg doses of representative batches, tablets made between 1969 and 1972 produced mean values for area under the 50 hours plasma concentration/time curve of 36.6 ng/ml/hr and four-day urinary excretion of 340 mug, compared with respective values of 67.5 ng/ml/hr and 696 mug for recently produced tablets.After 0.5 mg doses of four recent independently produced batches of Lanoxin tablets no significant between-batch difference was found for area under the plasma concentration/time curve or cumulative urinary excretion.Absorption of digoxin from batches of Lanoxin manufactured since May 1972 is uniform and consistent. Content uniformity is an inadequate measure of tablet quality, and consistent digoxin bioavailability cannot be ensured by existing regulations.

Biopharmaceutics↗