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Biomedical subjects

J Fothergill

Publications and source records attributed to J Fothergill.

25 records · Page 2Linked to original sources
PubMed1983

Intravenous prophylactic antimicrobial drugs in elective colorectal operations.

In a prospective, randomized, double blind study of 123 patients undergoing elective colorectal surgery, 61 received intravenously erythromycin gluceptate, and 62 received intravenously metronidazole perioperatively together with tobramycin. Three dosages of each drug were given. Eight patients in each treatment group had wound infections. Of these, only three in each treatment group were severe enough to require antibiotic therapy and to cause prolongation of hospitalization. Antibiotic levels in the serums of patients, in skin samples and in intestinal walls showed that metronidazole was most frequently detected at satisfactory concentrations in serum and that skin and the intestinal wall did not contain any detectable antibiotic.

Anti-Bacterial Agents↗
PubMed1982

Rapid method for determining antimicrobial susceptibility of Haemophilus influenzae.

A method was developed to determine the susceptibility of Haemophilus influenzae to ampicillin, cefamandole, and chloramphenicol by using the MS-2 system (Abbott Laboratories) for determining minimum inhibitory concentrations (MIC). The MS-2 results for 132 strains of H. influenzae were compared with the results of agar disk diffusion, agar dilution, and beta-lactamase tests. Twenty-four strains (18.2%) of H. influenzae were resistant to ampicillin by the agar dilution method, as opposed to 25 strains by the MS-2 method. For a beta-lactamase-negative strain, the agar dilution MIC was 4 micrograms/ml, and the MS-2 MIC was 16 micrograms/ml. Twenty-one strains produced beta-lactamase; two beta-lactamase-negative strains were resistant by MS-2, agar dilution, and agar disk diffusion. In addition, one beta-lactamase-negative strain, for which the agar dilution MIC was 32 micrograms/ml and the MS-2 MIC was 16 micrograms/ml, was sensitive by agar disk diffusion. Overall, the MS-2 method compared favorably with the agar dilution method for determining the MIC of ampicillin, cefamandole, and chloramphenicol for H. influenzae.

Ampicillin↗
PubMed1981

Amoebic liver abscess probably acquired in Birmingham, England.

Amoebiasis is usually acquired in countries where the disease is endemic. A case is presented of hepatic infection probably acquired indigenously with identification of the source of infection. The place of dual therapy for treatment is considered and the value of ultrasound scanning in management illustrated.

Adult↗