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Biomedical subjects

J Foreman

Publications and source records attributed to J Foreman.

At least 73 records · Page 4Linked to original sources
PubMed1990

The intrauterine sound environment of the human fetus during labor.

Ten pregnant women near term with medical indications for internal monitoring during labor were studied to quantify the intrauterine sound environment. The intrauterine background noise was measured with a miniaturized hydrophone placed transcervically at the level of the fetal neck under ultrasonographic guidance. In eight women no cardiovascular noise was audible and the intrauterine noise consisted predominantly of low-frequency noise (less than 100 Hz) from 60 to 85 dB. Above 100 Hz, the sound pressure level was less than 60 dB, decreasing to 40 dB above 500 Hz. In only two women maternal cardiovascular sounds were audible during uterine relaxation and disappeared during uterine contraction. Maternal bowel sounds and maternal vocalization were well above the intrauterine background noise. Because of this relative quietness, we hypothesized that the fetal acoustic environment could be altered significantly during antenatal vibratory acoustic stimulation.

Acoustic Stimulation↗
PubMed1989

Human fetal behavioral states after vibratory stimulation.

A total of 14 healthy pregnant women between 37 and 41 weeks' gestational age were studied to determine the effects of a 5-second external vibratory stimulus (100 Hz, square wave) on human fetal behavioral states. Fetal behavioral state observations were made with simultaneous recordings of fetal heart rate, gross fetal body movements, and fetal eye movement between 8:30 AM and 4:00 PM. During the first episode of behavioral state 1F (quiet sleep state) greater than or equal to 10 minutes duration on two consecutive half days, the vibratory stimulus was placed on the surface of the maternal abdomen over the fetal head. Each fetus received one 5-second vibratory stimulus during either the first or second half day of observation. The time at which the instrument was applied but no vibratory stimulus was administered was considered as the control period. All women were then observed for 2 hours after the control period and after stimulation. A transition period from a quiet sleep state to a stable active sleep state (state 2F, rapid eye movement sleep) averaged less than or equal to 3 minutes after stimulation, as compared with 23 minutes after the control period. These changes in fetal behavioral states persisted for 20 minutes after vibratory stimulation. There also was an immediate and sustained increase in long-term fetal heart rate variability, the number of fetal heart rate accelerations and gross fetal body movement during the first 20 minutes after stimulus, without changes in basal fetal heart rate. We hypothesize that changes in fetal behavior seen after application of low frequency vibratory stimulus are more physiologic than the profound changes in fetal heart rate and gross fetal body movement previously described after vibratory acoustic stimulation with an electronic artificial larynx.

Behavior↗
PubMed1989

Effects of low-frequency vibration on human term fetuses.

Thirteen healthy pregnant women between 37 and 41 weeks' gestational age were studied to examine effects of a 5-second external vibratory stimulus (100 Hz, square wave) on fetal heart rate, fetal breathing, and gross fetal body movement patterns. All fetuses were stimulated during an episode of low fetal heart rate variability (mean minute range less than or equal to 32 milliseconds for greater than or equal to 5 minutes) lasting at least 5 minutes. There was an immediate and sustained increase in long-term FHR variability, number of FHR accelerations, and gross fetal body movements after stimulation. Fetuses made breathing movements more irregularly after vibratory stimulus. We hypothesize that external low-frequency vibratory stimulus, applied during episodes of low fetal heart rate variability, causes a change from a state of quiet sleep to a state of rapid-eye-movement sleep in healthy term fetuses.

Acoustic Stimulation↗
PubMed1989

The mechanism of action of retrograde oxygen persufflation in renal preservation.

Vascular perfusion of gaseous oxygen has been used to prolong the in vitro survival of a number of isolated organs, and has been shown to improve the hypothermic preservation of ischemically injured kidneys that were subsequently transplanted. We have investigated the mechanism of this effect. Rabbit kidneys were subjected to 60 min of warm ischemia prior to preservation for 24 hr with Ross, Marshall, and Escott's hypertonic citrate solution, with or without retrograde oxygen persufflation (ROP) via the renal vein. It was found that adenine nucleotide levels were almost doubled in the ROP-preserved kidneys, principally due to higher adenosine triphosphate (ATP) concentrations. It was shown that cytochrome oxidase activity was unaffected by ischemia or preservation method, but studies with the metabolic inhibitors ouabain and a mixture of cyanide and iodoacetate suggested that ATP was being synthesized during the storage period but was also being utilized to power the active volume-regulating pump. Morphological examination revealed a much greater degree of cell swelling and cytological injury in the kidneys not subject to ROP, and the interstitial space appeared much reduced in the latter group. At the ultrastructural level, the ROP-treated kidneys showed generally well-preserved mitochondria, mostly in the energized "orthodox" configuration. In contrast, the mitochondria in the nonpersufflated kidneys were generally in the "condensed" deenergized state. We conclude that the provision of sufficient oxygen by ROP allows the continued production of ATP in sufficient quantities to permit improved maintenance of cellular volume and morphology under the conditions of low-temperature storage that we have studied.

Adenine Nucleotides↗