Biomedical subjects
J Ford
Publications and source records attributed to J Ford.
Phase II study of a high-dose regimen of cyclophosphamide and prednisolone in advanced non-Hodgkin's lymphoma of favorable histologic type.
Fifty-seven courses of cyclophosphamide (2.5-5.0 g/m2) and prednisolone (1.0 g/m2 x 5) were given to 22 patients with advanced stage IV non-Hodgkin's lymphoma of favorable histology. Six patients (27%) had a complete response (CR) (median duration, 10.1 months), and six (27%) had a partial response (median duration, 3.0 months). All patients in whom CR was achieved had a previous disease pattern of remission and relapse, and no patient refractory to previous therapy had a CR. This association of CR to disease pattern was statistically significant (P less than 0.0001). There was no difference in the survival of complete and partial responders. There was a trend to a higher response rate and statistically significant survival advantage (P less than 0.05) for patients with the nodular histologic types. The transient nature of response and the toxicity of the regimen, with four therapy-related deaths, render it unsuitable as routine therapy.
A new assay for picomole levels of androsterone and testosterone using Co-immobilized luciferase, oxidoreductase, and steroid dehydrogenase.
Explore the source record for details and available documents.
Families and feelings: a time for sharing.
Explore the source record for details and available documents.
Persistent infection of cell cultures with an Australian strain of Newcastle disease virus.
Explore the source record for details and available documents.
Pulmonary strongyloidiasis and lung abscess.
We report a case of lung abscess associated with pulmonary strongyloidiasis which occurred in an asthmatic patient three years after migrating to Australia from Burma where strongyloidiasis is endemic. Thiabendazole was effective in eradicating the Strongyloides infection.
Design of an equine mobile surgery table.
Explore the source record for details and available documents.
A pilot course on ward teaching methods.
Explore the source record for details and available documents.
Ideas which have influenced attempts to solve the problems of African trypanosomiasis.
Explore the source record for details and available documents.
Equine pharyngeal cyst (a case report).
Explore the source record for details and available documents.
Complications of sand impaction colic (a case report).
Explore the source record for details and available documents.
A.A.R.N. Position Paper on Health Promotion.
Explore the source record for details and available documents.
Treatment of secondary guttural pouch infection in horses.
Explore the source record for details and available documents.
Sodium content and neutralising capacity of some commonly used antacids.
Explore the source record for details and available documents.
Influence of exploratory celiotomy on the management of carcinoma of the cervix. A preliminary report.
Explore the source record for details and available documents.
A novel sequence arrangement of SV40 late RNA.
Explore the source record for details and available documents.
Kinetic studies on 3-hydroxykynureninase from rat liver.
3-Hydroxykynureninase was purified from rat liver. The Michaelis constants for L-kynurenine and L-3-hydroxykynurenine were determined to be 2.33 X 10(-4)M and 6.85 X 10(-5)M, respectively, at pH 8.41 and 37 degrees. With L-kynurenine as substrate, the enzyme was competitively inhibited by L-alanine, 3-hydroxyanthranilic acid, and several other compounds which contained structural features of either amino acid or aryl portions of the substrate. The effect of pH on the initial velocity, maximal velocity, and Michaelis constant, using L-kynurenine as substrate, was studied. Maximal velocity was strongly pH-dependent, with a maximum at pH 8.4. The Michaelis constant decreased from 11.4 X 10(-4)M at pH 7.1 to 1.30 X 10(-4)M at pH 9.0. Logarithmic plots of these data showed pKa's for functional groups ionizing in the enzyme-substrate complex and free enzyme active center of 7.6 and 8.5, respectively. Possible groups responsible for these ionizations were discussed.