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Biomedical subjects

J Forbes

Publications and source records attributed to J Forbes.

At least 73 records · Page 4Linked to original sources
PubMed1978

Chondrosarcoma of the thyroid cartilage.

A TUMOUR which had been present for nine years in the thyroid cartilage of a 45-year-old man, was shown on microscopy to be a chondrosarcoma. This tumour probably took its origin in a pre-existing benign tumour at this site. The literature on similar previously documented tumours is reviewed, and the classification, diagnosis and management of these rare tumours is briefly discussed. Primary cartilaginous laryngeal tumours are uncommon (Hyams and Rubuzzi, 1970; Zizmor et al., 1975). A tumour of the thyroid cartilage which had been present for about nine years was shown histologically to be a low-grade chondrosarcoma probably arising from a pre-existing chondroma at this site. The clinical and pathological features of this case are presented and discussed in the light of the available literature.

Chondrosarcoma↗
PubMed1977

Comparative trial of endocrine versus cytotoxic treatment in advanced breast cancer.

Ninety-two women with advanced breast cancer were allocated at random to receive either cytotoxic or endocrine treatment. Out of 45 women included in the cytotoxic treatment group, 22 (49%) achieved complete or partial remission of their disease, whereas of the 47 included in the endocrine treatment group, only 10 (21%) achieved such remission. Significantly longer survival times in the cytotoxic treatment group were most apparent among premenopausal women, 75% of such patients responding to cytotoxic drugs (median survival 46 weeks) compared with only 11% benefiting from ovarian ablation (median survival 12 weeks). In postmenopausal women with predominantly soft-tissue disease, however, additive hormonal treatment with tamoxifen produced remission rates and survival times equivalent to those produced by cytotoxic drugs.

Adenocarcinoma↗
PubMed1976

Transcriptional control of T4 coliphage-specific genes 30, 42, 43, rIIA, rIIB, and e.

Escherichia coli B/r (suo) was infected, at 30 degrees C, with T4Dam+, T4DamB24-amN82 (I-, 44-, DNA-negative phenotype), and T4DamN134amBL292 (33-, 55-, maturation-defective phenotype). A genetic ('transformation') assay was used to monitor transcription of genes 30 (polynucleotide ligase), 42 (deoxycytidylate hydroxymethylase), 43 (DNA polymerase), rIIA, rIIB, and e (endolysin). The principal results are: (I) All of the genes studied were transcribed exlusively from the so-called l-strand of phage DNA. (2) DNA synthesis and the maturation-defective proteins were required to turn-off transcription of genes 42, rIIA, tIIB, and 43. Experiments performed with chloramphenicol suggested that all phage-specific proteins required to turn-off transcription of these genes were not present until 6 to 8 min post infection (p.i.). (3) During a normal developmental programme, gene 30 was transcribed throughout the eclipse. DNA-negative and maturation-defective conditions had no obvious effect on transcription of this gene. (4) During a normal lytic event, two discrete waves of gene e transcription were observed. The late wave was dependent upon DNA-synthesis and presence of functional maturation-defective proteins. The early wave was unaffected by DNA-negative or maturation-defective conditions. Experiments with chloramphenicol indicated that, if any virus-specific proteins are involved with regulation of early e transcription, such proteins are present by 3 min p.i. The data are interpreted to mean that early gene transcription is regulated by a minimum of two mechanisms. One of these mechanisms is fully operational by the 3rd min and, among the genes studied, controlled early e transcription. A second mechanism becomes operational between 6 and 8 min p.i. and controls transcription of genes 42, 43, rIIA, and rIIB.

Animals↗
PubMed1974

Epidemiology of acute drug intoxications: patient characteristics, drugs, and medical complications.

Of 415 adult patients treated for acute drug intoxications in a university hospital emergency room, 64 (15.4%) required admission to the medical service for intensive care. A significantly larger proportion of patients over 40 years of age required hospitalization. Forty-eight of the episodes requiring hospitalization were identified as intentional drug intoxication. Women were admitted in 41 (64.0%) instances while men were admitted on 23 (36.0%) occasions. Non-barbiturate depressants, barbiturates, tranquilizers, and antidepressants were the drug classes most commonly incriminated. Almost one-half of all patients, however, had taken multiple drugs. Medical complications in these 64 patients included coma in 43 (67.2%), acute hypertension or hypotension in 21 (32.8%), and pneumonia in 16 (25%). Complications occurring less frequently were cardiac arrest in three (4.7%), anemia in two (3.2%), neuropathies, soft tissue necrosis, quadraplegia, renal failure, bullous dermatitis, and fetal death in one patient each. Two (3.2%) patients died as a result of drug ingestions. Forty per cent of patients had experienced previous episodes of acute drug intoxication.

Adult↗
PubMedDate not supplied

Two sequential randomized trials of community participation to recruit women for mammographic screening.

BACKGROUND: If mammographic screening is to reduce mortality from breast cancer, it is essential that a high proportion of the target population attend for screening. In order to achieve this, effective recruitment strategies are needed. This paper reports two trials of recruitment strategies for mammographic screening involving eight communities in rural New South Wales (NSW), Australia. METHODS: Each trial involved two matched pairs of towns in the Hunter Valley region of NSW. Towns were randomly allocated to intervention, receiving either mass media promotion or community participation in Trial 1 and community participation or family physician involvement in Trial 2. RESULTS: In Trial 1, significantly higher attendance rates were observed in the two towns that received the community participation intervention compared with their matched media promotion towns (63% vs 34%, P < 0.001 and 51% vs 34%, P < 0.01). In Trial 2, a significantly higher attendance rate was observed in one town that received the family physician involvement intervention compared with its matched town which received the community participation intervention (68% vs 51%, P < 0.01). There was no significant difference in attendance in the other pair of towns (68% vs 58%, P = 0.11). CONCLUSIONS: Both community participation and family practitioner involvement are more promising strategies for the promotion of attendance at mammographic screening facilities than media promotion alone.

Adult↗
PubMedDate not supplied

The Oak Tree Centre: initiatives for HIV-infected women, children, youth and families.

The Oak Tree Centre (Women and Family HIV Care Project) is designed to address the needs of women, youth, children and families affected by HIV infection in British Columbia. It is a conjoint project of the Women's Health Centre and British Columbia's Children's Hospital. Community involvement and the participation of individuals living with HIV infection continue to be vital components of the project. The ultimate goal is to enhance clinical and psychosocial care, and education, research and prevention initiatives for HIV-infected women, youth, children and families in British Columbia.

Adolescent↗
PubMedDate not supplied

Canadian national survey of perinatal HIV infection 1991-1992. Canadian Paediatric AIDS Research Group (CPAR).

OBJECTIVE: To define the burden of illness and the demographic characteristics of perinatally HIV exposed children in Canada. METHODS: Two national surveys of children born to HIV-infected mothers were conducted. The first survey captured information on all known cases up to March 1991, and the second, additional cases between April 1991 and May 1992. RESULTS: 220 children born to 204 HIV-infected mothers were identified. Quebec cases increased by 20% compared with 33% in Ontario (p < .003) and 50% in the rest of the country (p < .001). Quebec has a higher proportion of black mothers than the rest of Canada (p < .001). Sexual contact continues to be the major risk factor for maternal HIV infection. CONCLUSIONS: This survey confirms a substantial case load and provides an initial demographic profile of diagnosed HIV exposed infants in Canada.

Canada↗