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Biomedical subjects

J Foley

Publications and source records attributed to J Foley.

At least 109 records · Page 6Linked to original sources
PubMed1980

Experimental toxoplasmosis in calves and pregnant cows.

Experimental Toxoplasma gondii infections were studied in pregnant cows and in calves. In tests to compare their virulence, three strains of the toxoplasmal parasite were red to cats; then fecal oocysts were collected and given per os to calves. In tests to determine their effects, virulent tachyzoites or oocysts were given to 10 calves and to 22 pregnant cows by the oral, IV, or intraamniotic routes. Clinical signs were fever and inappetence. One cow in early gestation aborted 24 days after IV administration of tachyzoites. Gross and microscopic changes were slight and nonspecific. Toxoplasmas were isolaated from brain or liver of 4 cows, placenta of 2 cows, gastric contents of 2 near-term fetuses, and blood and tissues of calves. Toxoplasmas were not isolated from control cows.

Abortion, Veterinary↗
PubMed1978

Vestibulogenic imbalance.

Vestibular lesions may cause imbalance that long outlasts vertigo. Photographic analysis in five cases showed defects not only of the tilting reactions, which are of labyrinthine origin, but also of certain other postural reactions, notably the counterpoising and protective stepping reactions. All of these reflexes are unconscious and consequently such patients are rendered unstable in several ways simultaneously and may have difficulty describing their symptoms.

Adult↗
PubMed1978

Evidence for increased protease activity secreted from cultured fibroblasts from patients with pseudoxanthoma elasticum.

Abnormal polyanion metabolism in cultured fibroblasts from patients with pseudoxanthoma elasticum (PXE) was studied by incubating normal and PXE fibroblasts in culture medium containing 35SO4 for 96 hr and measuring differences in secreted 35SO4-labelled proteoglycans (35S-PG). PXE medium contained less high molecular weight (MW) 35S-PG and more low MW 35S-labelled molecules than normal medium. Addition of diisopropylfluorophosphate (DFP), a serine protease inhibitor, to the media after the 96 hr incubation resulted in no change in the MW distribution of 35SO4-labelled molecules in normal media. However, DFP treated PXE medium contained significantly more high MW 35S-PG than either untreated PXE medium or DFP treated normal medium. High MW 35S-PG was isolated from PXE fibroblast culture medium and incubated with serum free medium from either normal or PXE fibroblast cultures. There was significantly more degradation of this 35S-PG to low MW 35S-labelled molecules by PXE medium than by normal medium. 32P-DFP, which binds to the active site of serine proteases, was added to serum free medium from normal and PXE cultures. The specific radioactivity of PXE medium was 4 times greater than that of normal medium. These lines of evidence are consistent with the hypothesis that a biochemical defect in cultured PXE fibroblasts is the increased secretion of a serine protease that can degrade sulfated proteoglycans.

Fibroblasts↗
PubMed1978

Antibody response of horses to Mycoplasma mycoides subsp capri.

In horses given whole cultures or cells of Mycoplasma mycoides subsp capri (by subcutaneous and intravenous injections), antibody responses were measured by serologic procedures. During an immunization period of 22 weeks, horses produced an antiserum that was used to identify M mycoides subsp capri by agglutination, complement-fixation, and fluorescent antibody (FA) tests, but not by the growth-inhibition test. Horses that were injected with whole cultures of M mycoides subsp capri responded better than horses that were injected with only cells, ie, antibodies were detectable sooner by agar gel diffusion and FA tests and the serums displayed more bands of precipitation. The FA reagent was stable during lyophilization and storage at 5 C for 60 days.

Agglutination Tests↗
PubMed1975

Metabolism of dog gastric mucosa. Nucleotide levels in parietal cells.

Adenine and pyridine nucleotide levels as well as those of phosphate, phosphocreatine, lactate, pyruvate, beta-hydroxybutyrate, acetoacetate, glucose, and glycogen were measured in histologically defined parietal and mucous cell sections of biopsies of dog gastric mucosa at rest, and in various secretory states. As a result of stimulation of secretion, there appeared to be no change in adenine nucleotide levels, or phosphocreatine, but there was a rise in inorganic phosphate and a fall in phosphorylation potential. However, there was a marked increase in NADH, but no change in NADPH with onset of acid secretion. The increase in the lactate to pyruvate ratio showed that the increased NADH level occurred in the cytoplasm and these data are discussed with reference to change in cell pH.

Acetates↗