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Biomedical subjects

J Fillmore

Publications and source records attributed to J Fillmore.

2 recordsLinked to original sources

A simple institutional educational intervention to decrease use of selected expensive medications.

OBJECTIVE: To determine whether a simple educational intervention can influence use of prescription medications at an institution. DESIGN: Cost-effectiveness analysis of prescribing behavior before and after an educational intervention. SETTING: A large, urban, free-standing academic rehabilitation hospital. PARTICIPANTS: Physicians, residents, and physician extenders. INTERVENTIONS: The hospital's pharmacy department provided simple written educational material about cost differences of various prescription medications to attending and resident physicians, nurse leaders, and case managers. Telephoned reminders were given when targeted medications were prescribed. MAIN OUTCOME MEASURES: Total prescription medication use was recorded monthly for 12 months before and after the intervention. Pharmaceuticals monitored were subcutaneously administered anticoagulants, histamine type 2 (H2) blockers, and nonsteroidal anti-inflammatory drugs (NSAIDs). RESULTS: A 32% decrease in use of the more costly anticoagulant and a 20% increase in use of the less costly anticoagulant (p <.0001), representing an estimated annual savings of nearly $66,000. Use of more costly H2 antagonist decreased 50% and use of less costly H2 antagonist increased 128% (p <.0001). With written intervention only, use of more costly NSAIDs declined 28%, whereas use of less costly NSAIDs increased 58% (p <.0020). CONCLUSION: Providing physicians with simple pharmaceutical cost information and telephone reminders decreased the use of targeted more costly medications.

Anticoagulants↗

Chronic repeated cocaine administration increases dopamine D1 receptor-mediated signal transduction.

Alteration in dopamine D1 receptor-mediated signal transduction following repeated cocaine administration was investigated. Male Fischer rats were administered saline or cocaine HC1 (15 mg/kg, i.p.) three times daily at 1-h intervals for 1, 7, or 14 days. Stimulation of adenylyl cyclase activity by dopamine and the selective dopamine D1 receptor agonist, (+/-)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2, 3,4,5-tetra-hydro-1 H-3-benzazepine hydrobromide (SKF 82958), was significantly greater in the nucleus accumbens and caudate putamen of animals injected with cocaine for 14 days compared with control animals, but was unchanged in animals administered cocaine for 1 or 7 days. These results suggest that dopamine D1 receptor signal transduction in the nucleus accumbens and caudate putamen is enhanced following chronic repeated administration of cocaine.

Animals↗