Search PubMed⌕ Search

Biomedical subjects

J Fevery

Publications and source records attributed to J Fevery.

At least 163 records · Page 9Linked to original sources
PubMed1984

Alpha-1-antitrypsin (AAT) and its stimulation in the liver of PiMZ phenotype individuals. A "recruitment-secretory block" ("R-SB") phenomenon.

PiMZ individuals in conditions of clinical stimulation show a peculiar immunohistochemical staining pattern for alpha-1-antitrypsin (AAT) in the liver: 1) the positivity involves large zones of parenchyma (up to 100% of hepatocytes); 2) in zone 2 and zone 3 hepatocytes the positivity appears in the form of crescents or rectilinear arrays along the sinusoids. This new pattern is designated type II, in contrast to type I which occurs in periportal hepatocytes in the form of inclusions spread over the whole cytoplasm. This peculiar staining pattern is associated with serum elevation of AAT and is considered to be an expression of liver reactivity. Type II positivity marks the hepatocytes which are newly recruited for the synthesis of AAT; owing to its defective export, the Z AAT is retained within the cell and detectable by immunohistochemistry. Thus this staining pattern is an expression of both recruitment for synthesis and block of secretion ("Recruitment-Secretory Block" "R-SB" phenomenon). In PiMZ individuals, the secretory block affects selectively and exclusively the Z fraction of AAT. At the EM level the vast majority of the retained protein is found in the RER, which represents the major and the earliest site of storage. Viewed in the framework of present knowledge of glycoprotein biosynthesis, the results of this study shed further light on the nature and cellular site of the Z AAT defect.

Biopsy↗
PubMed1984

Influence of sex and sex steroids on bilirubin uridine diphosphate-glucuronosyltransferase activity of rat liver.

Bilirubin uridine diphosphate-glucuronosyltransferase activity was markedly higher in liver preparations of adult female rats when compared with adult male rats. Ovariectomy decreased the levels in females whereas orchiectomy produced an increase in males. Totally opposite results were obtained when assaying p-nitrophenol uridine diphosphate-glucuronosyl-transferase; this suggests the existence of different enzymes. Administration of physiologic amounts of testosterone decreased enzyme activities in orchiectomized males to normal levels. Estradiol had no effect but progesterone significantly enhanced the transferase activity of gonadectomized females. The effect was more pronounced when progesterone was associated with estradiol. The combined treatment of ovariectomized rats resulted in physiologic plasma levels of sex steroids and could increase the levels of glucuronosyl-transferase to values of normal females. Male and female sex hormones thus exert opposite effects on bilirubin uridine diphosphate-glucuronosyltransferase. If applicable to humans, this might explain the differences in serum bilirubin levels in adult men and women, and in the prevalence of Gilbert's syndrome.

Animals↗
PubMed1984

Complete recovery from hepatitis B and associated hemolysis in a patient with underlying T-cell deficiency.

A 17-yr-old woman presented with acute hepatitis B. She had preexisting well-documented immune deficiency, clinically apparent as chronic mucocutaneous candidiasis, and recurrent severe viral infections. Life-threatening but spontaneously resolving Coombs-negative hemolysis complicated the recovery phase. Complete healing of the hepatitis with disappearance of hepatitis B surface antigen from serum and normal hepatitis B surface antibody and hepatitis B core antibody production occurred in spite of T-cell dysfunction.

Acute Disease↗
PubMed1984

Cystadenoma of the common bile duct demonstrated by endoscopic retrograde cholangiography: an uncommon cause of extrahepatic obstruction.

Obstructive jaundice may rarely be caused by a benign tumor of the biliary tract. We describe a patient in whom the diagnosis of cystadenoma of the common bile duct was established. Complete resection of the tumor could be carried out. The clinical, radiological, and histological features of this neoplasm are reviewed.

Cholangiopancreatography, Endoscopic Retrograde↗
PubMed1983

Comparative histology of acute hepatitis B and non-A, non-B in Leuven and Padova.

A histological study was performed on liver biopsies from patients with acute hepatitis A (n = 13), B (n = 35) and non-A, non-B (nAnB) (n = 35) in search for microscopical features characteristic for each type of hepatitis. Biopsies from two centres (Padova, Italy and Leuven, Belgium) were studied in order to determine whether the histological pattern in acute hepatitis A, B and nAnB may differ from one centre to another. The histology of cases of hepatitis A and B from Italy and Belgium did not differ. Less liver cell plemorphism was found in hepatitis A than in B. Clear differences were observed between acute hepatitis nAnB occurring in Padova when compared with cases from Leuven. The Padova-biopsies obtained from patients with transfusion-induced viral hepatitis were mainly characterized by a high degree of lympho-histiocytic intrasinusoidal infiltration whereas the Leuven-biopsies, mostly taken in patients with sporadic hepatitis, were characterized by the presence of numerous acidophilic bodies and Mallory body-like cytoplasmic alterations. Morphologically, the latter cases appear to be closely related to hepatitis B.

Belgium↗
PubMed1983

Ultrasonography of liver haemangioma. A report of 35 patients totalizing 53 lesions.

During the last two years a total of 53 liver angiomas in 35 patients were examined by sonography. The angiomatous nature of these lesions was proven by angiography, CT, laparotomy, laparoscopy or autopsy. In this material the most striking sonographic data are the reflective character of the angiomas (94%), the subcapsular location (70%), the small size under 2 cm. (32%) and the multiplicity (35%). 90% of the lesions larger than 3 cm. tend to display polylobular contours.

Adult↗
PubMed1983

Prognostic significance of piecemeal necrosis in acute viral hepatitis.

The predictive value of piecemeal necrosis (PMN) in acute hepatitis was investigated in 62 patients (39 hepatitis B virus infection, 9 hepatitis A virus infection and 14 possible hepatitis NANB virus infection). The 62 initial biopsies were blindly recoded and classified into three groups: 1. Acute hepatitis with signs of possible transition to chronicity (AHTC) (n = 35) (i.e. a picture of acute hepatitis associated with PMN). 2. AHTC-borderline group (BL) (n = 15) (i.e. a picture of acute hepatitis with minimal PMN). 3. Uncomplicated acute hepatitis (AH) (n = 12) (i.e. a picture of acute hepatitis without PMN). Follow-up of the patients revealed an evolution to chronicity in a very high percentage of the AHTC-cases of hepatitis B (95%) and NANB (89%) etiology. Also 67% of the BL-cases of hepatitis B etiology developed chronic liver disease. In hepatitis B the immunohistochemical pattern of HBsAg is of additional help. In hepatitis A, PMN is often present (5/9) but no evolution to chronicity was observed. This study shows that PMN in acute hepatitis appears to be a useful prognostic feature for chronicity in hepatitis B and NANB.

Acute Disease↗
PubMed1983

Maximal hepatic bilirubin transport in the rat during somatostatin-induced cholestasis and taurocholate-choleresis.

A steady maximal biliary secretion of bilirubin has been produced in male Wistar rats, recovered from anesthesia, by continuous infusion of 256 nmol of unconjugated bilirubin per hour per 100 gm body weight, after priming with 3.4 mumols. The administration of somatostatin (2 micrograms/hr/100 gm body weight) produced a reversible decrease of bile flow and bile acid excretion while bilirubin output was unchanged. After discontinuation of somatostatin, a slight increase in the output of bilirubin conjugates was observed with the rapid recovery of bile flow. Administration of Na+ taurocholate at increasing rates (30 to 480 nmol/min/100 gm body weight) progressively enhanced bile flow and bile acid secretion. The rate of secretion of bilirubin conjugates increased to 18% above the values in controls at a taurocholate dose of 120 nmol/min/100 gm body weight and remained at that level with higher amounts, in spite of further increases in flow. Under Na+ taurocholate, somatostatin failed to reverse the enhancement of bilirubin output, although it still inhibited the secretion of bile acids and bile flow. A mechanism linked to osmotic flow induced by taurocholate would appear to serve as a component of the total capacity of the hepatocyte to transfer bilirubin conjugates into the canaliculus. At low bile-acid secretory rates this component seems of minor quantitative importance, whereas a major (specific) pathway seems not yet saturated.

Animals↗
PubMed1983

Early diagnosis of Budd-Chiari syndrome by computed tomography and ultrasonography: report of five cases.

In 5 patients with Budd-Chiari syndrome, computed tomography after intravenous bolus injection of iodinated contrast agents demonstrated images not previously seen in other diseases. The images are compatible with stagnation of contrast material at the periphery of the liver. In 3 of the 5 cases, grey-scale ultrasonography failed to document the normal hepatic veins draining into the inferior caval vein, but showed an intrahepatic network of comma-shaped venous structures. It is proposed that these two noninvasive approaches can help in establishing an early diagnosis.

Adult↗
PubMed1983

Case report: fourteen-year follow-up of an apudoma of the bile ducts at the hilum of the liver.

A patient presented with a sclerosing tumor at the bifurcation of the main hepatic ducts and was followed for 14 yr after the initial symptoms. Palliative surgery was performed in 1968, followed by a remission of 10 yr. A reintervention in 1979 showed an impressive fibrotic mass that could be extirpated. The patient is again in complete remission for almost 3 yr. A tumor biopsy specimen, obtained at the second intervention, showed an apudoma-type tumor. This was confirmed by a positive Grimelius stain and by immunohistochemical investigation.

Adult↗
PubMed1982

New ultrastructural marker in hepatocytes in non-A, non-B viral hepatitis.

A new ultrastructural cytoplasmic marker designated as type 2, and distinct from type 1 previously associated with NA-NB hepatitis in chimpanzees, was found in hepatocytes of two patients and of one experimentally infected chimpanzee. These cases represent a minority of all cases we studied as presumed NA-NB viral hepatitis. Type 2 marker consists of tubular structures composed of an assembly of ring-like units coated with smaller uniform fragments, accumulated in different patterns in dilated cisternae of the endoplasmic reticulum. Preliminary data using immunofluorescence with NA-NB hepatitis convalescent serum and antiserum against fibrinogen are reported. Type 2 marker may represent a different agent or a different reaction pattern to one agent of NA-NB viral hepatitis. Its features are compared with those of hepatitis B.

Adult↗
PubMed1982

Clinical evaluation of the liver cell membrane autoantibody assay.

To evaluate the clinical significance of the liver cell membrane autoantibody (LMA) assay, we studied the presence, titre and immunoglobulin classes of LMA in 162 patients with various liver diseases and 156 controls. LMA was detected predominantly in patients with HBsAg-negative chronic active hepatitis (73% of 26 patients), but was also found in lower prevalences in other liver diseases, such as primary biliary cirrhosis syndrome (43% of 28 patients). LMA-positive primary biliary cirrhosis patients could be distinguished from LMA-positive patients with other liver diseases by the virtual absence of IgG class LMA. The LMA assay adds to the panel of assays for non-organ-specific autoantibodies in that it is more specific for autoimmune liver disease and in that it increases the diagnostic yield of autoantibody assays, e.g. in HBsAg-negative chronic active hepatitis from 77 to 92%. Immunosuppressive therapy status and biochemical parameters of disease activity, such as transaminase values, did not show a statistically significant relationship with the prevalence, the titre and the immunoglobulin class of LMA. It is concluded, that LMA is a sensitive and specific diagnostic marker for autoimmune liver disease.

Acute Disease↗