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Biomedical subjects

J Fernandez

Publications and source records attributed to J Fernandez.

At least 199 records · Page 11Linked to original sources
PubMed1982

Ten-year pathological study of Beall mitral valve prostheses.

Detailed pathological studies are reported on 20 cloth-covered Beall mitral valve prostheses, which had to be removed for valve failure nine months to 10 years after implantation. Results in all patients except one indicated that there was a progressive and persistent granulomatous reaction that continued up to at least 10 years. Although the rate of tissue ingrowth into the valve decreased with time, the total volume of tissue formation increased. Cloth wear and disruption and deformity of the teflon discs was frequently seen. In these 20 valves the desired result--namely, the complete and smooth endothelialisation of the prosthesis--was certainly not achieved.

Adult↗
PubMed1981

Fungal endocarditis complicated by mycotic aneurysm of sinus of Valsalva, interventricular septal abscess, and infectious pericarditis: unique M-mode and two-dimensional echocardiographic findings.

A 26-year-old male with fungal aortic endocarditis is presented in whom unique M-mode and two-dimensional echocardiographic findings permitted a diagnosis of mycotic aneurysm of right sinus of Valsalva and ventricular septal abscess preoperatively. The aneurysm was excised, and the affected aortic and tricuspid valves were replaced with valve prostheses.

Abscess↗
PubMed1981

Giant Lambl's excrescences of papillary muscle and aortic valve: echocardiographic, angiographic, and pathologic findings.

A 54-year-old female with rheumatic heart disease was found to have a mass in the left ventricle by echocardiography and angiography. Subsequently, giant Lambl's excrescences of papillary muscle and aortic valve were confirmed by operation and pathologic examination. Possible complication from cardiac catheterization could be avoided by the utilization of echocardiography prior to catheterization.

Aortic Valve↗
PubMed1979

Malignant cardiac myxoma with cerebral metastases.

Two cases of cardiac myxoma with secondary involvement of the brain and death are reported. In one case, tumor emboli to the middle cerebral artery caused massive cerebral infarction, while in the other case true cerebral metastasis developed in the cerebrum and cerebellum, with rapid demise ensuing in both patients. It is emphasized that an emergency exists in cases ihat prompt echocardiography and computerized tomography of the brain are indicated. The second case represents the only instance of cardiac myxoma behaving as a true malignant neoplasm with actual invasion of the neural tissues recorded in the literature.

Brain Neoplasms↗
PubMed1978

Structure of the leech nerve cord: distribution of neurons and organization of fiber pathways.

The abdominal nerve cord of the leech Macrobdella decora was studied under the light and electron microscopes. The ganglionic cortex consists of six hemicone-shaped packets of neuronal perikarya and apical processes regularly assembled in bilaterally symmetric rows. The orderly projection of the apical processes into the hilum of the packets is also followed by an orderly distribution of their branches across the neuropile. This part of the ganglion is made of two symmetrical halves or hemineuropiles enclosing two types of nerve tissue: coarse and fine neuropiles. The coarse neuropile has seven longitudinal and four commissural tracts of fibers and a distinctively segregated synaptic zone. Nerve processes in this neuropile mostly proceed from the neurons in the ganglia and some are the branches of giant afferent axons. The fine neuropile includes several longitudinal tracts of fibers and a non-segregated synaptic zone. Most nerve processes in this neuropile are small afferent axons and some come from neurons in the ganglia. Bundles of axons in the connectives result by the orderly projection of the neuropile longitudinal tracts and together form fiber pathways connecting the synaptic zones of successive ganglia. Pathways of through-ganglia giant axons, linking the coarse neuropile synaptic zones, and of small axons, linking the fine neuropile synaptic zones, are described.

Animals↗
PubMed1978

Massive mitral regrgitation from chordal rupture and coronary artery disease.

The precise mechanism that causes spontaneous rupture of chordae tendineae remains unknown. That it may occur in patients with no disease other than underlying or associated coronary artery occlusion has not been previously reported. Six patients with chordal rupture were found among 600 patients who underwent operation for mitral regurgitation in a 6-year period. All 6 patients without exception underwent simultaneous mitral valve replacement and coronary revascularization. The salient clinical features of these patients are summarized, and 1 case is reported in detail.

Aged↗
PubMed1978

Double-blind comparison of cefazolin and cephalothin in open-heart surgery.

Ninety-nine patients undergoing cardiac surgery were randomly assigned to treatment with cefazolin and cephalothin to compare the effectiveness of these cephalosporins in the prevention of postoperative infections. The incidence of infections was low with both antibiotics (cefazolin 2.1 percent, cephalothin 4.6 percent). Intraoperative serum cefazolin levels were more evenly distributed, whereas a wide dispersion of cephalothin levels was observed. There was no measurable antibiotic detected in cardiac tissue samples in the majority of the cases. Adverse reactions (skin rashes) occurred only in three patients, all receiving cephalothin. It is concluded that cefazolin is as safe and effective as cephalothin in the prevention of postoperative infection in patients undergoing open-heart surgery.

Adult↗
PubMed1976

Zinc, copper and ceruloplasmin in arteriosclerosis.

High serum levels of Zn, Cu and Ceruloplasmin were found in 13 patients with arteriosclerosis when compared with controls. The Zn/Cu ratio is much higher in arteriosclerotic patients than in healthy subjects.

Adult↗
PubMed1976

Late thrombosis of the aortic Bjork-Shiley prosthesis. Its clinical recognition and management.

Seven cases of massive thrombosis of an aortic Bjork-Shiley prosthesis were encountered among 433 valvular implants. Four patients died before treatment could be instituted, and three underwent repeat surgery successfully. Anticoagulation therapy was probably well maintained in four, and poorly maintained in three patients. These cases illustrated the need for a high index of suspicion and prompt recognition of this complication in patients with Bjork-Shiley prostheses. The diagnosis of massive thrombosis should be suspected with the rapid onset of (1) signs of congestive heart failure, (2) absence or attenuation of valvular clicks, (3) aortic regurgitation, or (4) hemolytic anemia. Salvage of these patients requires emergency replacement of the thrombosed prosthesis or removal of the thrombus.

Aged↗