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Biomedical subjects

J Fenton

Publications and source records attributed to J Fenton.

87 records · Page 5Linked to original sources
PubMedDate not supplied

Sutureless and reduced suture anastomosis of hollow vessels with fibrin glue: a review.

Research in reduced suture fibrin glue (FG) and sutureless FG anastomosis has been lagging behind FG utilization in other surgical fields. A review of the literature for vascular, esophageal, tracheal, gastrointestinal, common bile duct, ureteral, vas deferens, and Fallopian tube FG anastomosis indicates that reduced suture FG and sutureless FG procedures may be performed with less training, reduced operating time, leakage, ischemia, inflammation, and necrosis compared to sutured techniques. Reduced suture FG vascular anastomosis augments early anastomotic strength. Suture number for esophageal, tracheal, and tracheobronchial anastomoses can be reduced with FG. Bursting strength in pig small intestine and rat colon was lower at 4 days postoperatively, but returned to sutured strength at 7 days. Mortality was unaffected, and 18-month follow-up in sutureless FG intestinal anastomosis in pigs showed no stenosis. Preliminary ureteral studies have demonstrated successful sutureless FG and reduced suture FG laparoscopic techniques in pigs. Reduced suture FG and sutureless FG vas deferens anastomosis may reduce sperm granuloma rates, with increased patency and pregnancy rates. Patency and pregnancy rates have been similar for tubal FG, reduced suture FG, autologous fibrin glue (AFG), and sutured anastomosis. Any risk of viral transmission or immune response is eliminated by AFG. While there are few studies in many areas of FG hollow vessel anastomosis, the current literature illustrates many of the advantages of FG over other anastomotic techniques and should provide impetus for continued research in this promising field of surgery.

Anastomosis, Surgical↗
PubMedDate not supplied

Hydromorphone and hydrocodone interference in GC/MS assays for morphine and codeine.

The specificity of a GC/MS assay of morphine and codeine was examined with particular regard to the potential interference due to hydromorphone and hydrocodone, compounds that cross-react extensively in opiate screening tests. A GC/MS method with solid-phase extraction and acetylation or trimethylsilylation was used. The equilibrium between keto and enol forms of the potential interferents was evaluated. Sodium borohydride was tried as a means for converting potential interferents into products that are more clearly separated from morphine and codeine. It was found that borohydride reduction proceeded easily and led to products that could be distinguished from morphine and codeine. Moreover, the quantitation of morphine in the presence of hydromorphone was improved if the borohydride step was included in the analysis.

Acetylation↗
PubMedDate not supplied

[A prospective study of chronic radiation lesions of the small intestine after radiotherapy of gynecologic cancer].

A prospective study was made of 80 patients with a history of gynecological malignancy, and who had received radiotherapy 2 to 5 years previously in the same centre, with the aim of determining the incidence of lesions of the small intestine after pelvic radiotherapy. Various moderate gastrointestinal symptoms were seen in 33 patients and incapacitating diarrhea in 2. Thirty-seven patients underwent gastrointestinal investigations. The great majority had a good nutritional status and normal laboratory results. Fecal losses on a normal oral diet and alpha-1-antitrypsin clearance were most often normal (3 cases of steatorrhea, 8 of creatorrhea). Small bowel barium studies revealed minor abnormalities of folds in 5 cases. There was no correlation between clinical symptomatology and the existence of laboratory and radiological abnormalities. This study shows the usual good tolerance of pelvic radiotherapy by the small intestine, at least in the mid-term. Routine investigations seeking sub-clinical intestinal lesions do not appear to be justified in patients who have undergone pelvic radiotherapy.

Adult↗
PubMedDate not supplied

Nasopharyngeal carcinoma--the Irish experience.

Ten new cases of nasopharyngeal carcinoma were diagnosed at our unit during a recent twelve month period. An evaluation of these cases is presented. This stimulated an examination of the national data for the years 1981-1990 and it was discovered that 69 cases were diagnosed in that period. A chart review was performed of the patients with nasopharyngeal carcinoma that were treated at St. Lukes Hospital 10 years previously and compared to the 10 recently diagnosed patients. This data highlights: the young age at which this tumour can occur; that there has been no improvement in the early detection of these neoplasms and the importance of an ENT assessment for patients presenting with cervical lymphadenopathy, persisting middle ear effusion or atypical headaches.

Adolescent↗