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Biomedical subjects

J Feingold

Publications and source records attributed to J Feingold.

276 records · Page 16Linked to original sources
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[Genetics and cancer].

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Blood Group Antigens↗
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[Alpha-1-antitrypsin and cystic fibrosis (author's transl)].

A methodical study of the alpha-1-antitrypsin serum level and the Pi type in 69 CF children, 156 CF heterozygote parents and 200 blood donors from Paris, has been made. Although the PiZ allele frequency was found to be higher in the CF population, especially in fathers, than in the reference population, the difference is not statistically relevant. Therefore there does not seem to be a relation between cystic fibrosis and the Pi alleles system.

Adolescent↗
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[Collection of familial data in pharmacogenetics. Methodological problems].

The purpose of this paper is to show the problems with family data collection in a pharmacogenetic study, the aim of which was to study the genetic polymorphism of inducibility of cytochromes P4501A by polycyclic aromatic hydrocarbon (PAH). Data were collected from 76 smoker nuclear families (315 volunteers). A caffeine test, a blood sample and answers to a questionnaire were obtained from each healthy volunteer. It was a crucial problem to recruit nuclear families with healthy smoker father and/or mother and 2 smoker children. On 127 answers, 22 families were not eligible, 27 refused and 10 had a single child, that meant secondary refusals. Problems differed with origin of the recruitment. Included were 40 families obtained from 3 antismoking outpatient departments, 29 from general practitioners but 6 only from students. The family rates with 2 parents/2 children were significantly higher with general practitioners (p < 0.01). This emphasized their part in epidemiologic studies. Problems with the use of methodology were bound to acceptability of the tests which were better in females (p < 0.05), and a change in caffeine form could improve this acceptability. Lastly, difficulties with laboratories constraints required a very good coordination between families, nurses and laboratories.

Cytochrome P-450 Enzyme System↗