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Biomedical subjects

J Feingold

Publications and source records attributed to J Feingold.

At least 235 records · Page 13Linked to original sources
PubMed1975

Associated congenital malformations in retinoblastoma.

A complete family investigation was made for 598 cases of retinoblastoma and details of any associated congenital malformations were recorded. Associated malformations were found in seven cases, four of which were cleft palate. There was a highly significant difference between the frequency of cleft palate in our cases with retinoblastoma and the frequency in the general population. This result supports the hypothesis that cases of retinoblastoma with associated congenital malformations are caused by germinal mutations.

Child↗
PubMed1975

Congenital urinary tract malformations: epidemiologic and genetic aspects.

436 index patients with major congenital urinary tract malformations, 385 with upper and 51 with lower urinary tract anomalies, were studied. A significant male sex predominance was noted in each group. No apparent correlation was found between parental age, birth order, birth weight and incidence of these malformations. The association with abnormalities outside the urinary tract was more frequent in the upper urinary tract group. In this group, the mean consanguinity index was 283-10(-5) and, among those patients where a family study was made, 16.6% had positive family histories. The incidence of urinary tract malformations was 4.0% for the first degree relatives, and 1.1% for second degree relatives (grandparents only). In this group, the concordance rate was 50% in four monozygotic, and 0% (nil) in three dizygotic, twin pairs. The findings, in agreement with studies of other congenital malformations, suggest at least in part, a multifactorial etiology, particularly in the case of upper urinary tract malformations, depending upon genetic predisposition and environmental factors.

Abnormalities, Multiple↗
PubMed1975

[Prevalence of etinoblastoma in the Midi-Pyrenées area].

The frequency of retinoblastoma was estimated in southwest France (Midi-Pyrénées) during the 1950-1969 period. Twenty-three cases were detected among 507 157 liveborns. After correcting for the probability of ascertainment of patient, the estimated frequency is 1 per 15 849 births. The proportion of unilateral cases is estimated 91 percent after correcting for the higher probability of ascertaining bilateral cases.

Eye Neoplasms↗
PubMed1975

[Frequency of birth defects. Study of a maternity hospital in Paris].

A retrospective study of 20,591 live born babies and still birth was made in order to estimate the incidence of congenital malformations total and by type diagnosed at birth. The total incidence is 1,74 p. 100. The sex ratio, the mean birth rank and parental ages were computed for the different types of malformation and in the control group. The birth weight was low in case of severe malformation. It was found that malformations were associated with significantly raised abortions and still birth rates among previous pregnancies.

Abortion, Spontaneous↗
PubMed1975

Statistical study on double paraproteinemias. Evidence for a common cellular origin of both myeloma globulins.

Double paraproteinemias (DPP) are usually considered as resulting from a proliferation of two independent clones of cells. The present study describes a statistical analysis based on 141 published cases of DPP. The incidence of the heavy chain classes as well as of light chain types association has been compared with the frequency of occurence of the same H and L chains in simple paraproteinemias. Computation of the frequency of associations showed that different heavy chains are randomly associated in DPP. However, light chains are more frequently of the same type in both immunoglobulins more so than could be expected on the basis of a biclonal hypothesis (p less than 0.005). This preferential occurence of identical light chains suggests a linkage in the synthesis of two proteins and it favours a monoclonal origin of myeloma cells in DPP.

Humans↗