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Biomedical subjects

J Feingold

Publications and source records attributed to J Feingold.

At least 199 records · Page 11Linked to original sources
PubMed1980

[Causes of death of children at the Hôpital des Enfants-Malades. Statistical study of 1 098 pathologic and clinical records collected from 1966 to 1975 (author's transl)].

The clinical and histopathologic records of 1 098 children under 15 years of age, deceased at the hôpital des Enfants-Malades from 1966 to 1975 were studied. This material represents 44% of the total deaths of the same period. This study uses both the international classification of diseases and W.H.O.'s criteria, for distinguishing in causes of death between the principal cause, the immediate cause and associated causes. A higher mortality rate was observed in boys (58%), during the first year of life (80%), during the first 12 hours following admission (13%) and during the night. Causes of death are rarely isolated (10%), more often multiple: double (50%), or even triple or more (40%). Malformations represent 40% of the main causes of death, infections 14%, perinatal mortality 11%. Among immediate causes, infectious diseases are responsible for 23% of the deaths, respiratory disorders for 15%. Among associated causes are seen, in decreasing order of frequency: surgical procedures, prematurity, known or unrecognized associated malformations. Infections occurring during hospitalization represent the principal iatrogenic disorders. Anatomico-clinical examination failed to find an immediate cause of death in 25% of the cases and a principal cause in 7%.

Adolescent↗
PubMed1979

[Incidence of cystic fibrosis in Brittany (author's transl)].

Incidence of cystic fibrosis has been estimated in three adjacent geographic areas of Brittany: North Finistere, South Finistere and Morbihan. This incidence is respectively 6.0 x 10(-4), 4.8 x 10(-4), 2.9 x 10(-4) in these three areas. A significant difference between North Finistere and Morbihan was found. Without proofs in favor of natural selection, genetic drift seems to be a possible explanation of this variation. Moreover, as in other studies, a genetic heterogeneity of the disease was not shown.

Cystic Fibrosis↗
PubMed1979

Congenital glaucoma: genetic models.

Modes of inheritance of congenital glaucoma have been studied. Two methods of analysis, complex segregation analysis and frequency of congenital glaucoma in second- and third-degree relatives, did not permit one to retain a unitary mode of inheritance ofthis malformation. Genetic heterogeneity of congenital glaucoma is proposed. Recurrence risks and guidelines for genetic counseling in specified situations are given.

Adult↗
PubMed1979

HLA in populations: an approach for genetical susceptibility to cancer.

The geographical correlations between the incidence of various cancers and the HLA and ABO antigen frequencies are studied. There is, for example, a positive correlation between breast and colorectal carcinoma and AI, B8 and B12 antigens, and a negative one between prostate carcinoma and B12. The role of the HLA system itself or other genes involved in these associations is discussed. This study gives some evidence of a possible genetic background of susceptibility or resistance to cancer.

ABO Blood-Group System↗
PubMed1979

Seroepidemiology of cytomegalovirus infections during the first years of life in urban communities.

Using indirect haemagglutination assay, combined with a collection of blood samples on blotting cards, seroepidemiological surveys of cytomegalovirus infections during early infancy have been done in different populations (French and immigrant) in urban areas. The comparison of CMV antibody status of mothers and their children at 10 months and at 2 years of age enables possible factors of viral transmission to be defined. During the first year of life, seropositive mothers were the only source of infection and they remained the main source during the second year. Socioeconomic class and educational level are determinant factors in the incidence of viral transmission.

Child, Preschool↗
PubMed1979

[Genetic counseling in consanguinous marriages].

The authors report their own experience as regard to the genetic counseling for consanguineous marriages. They observe that outpatients still marry and procreate despite the medical advices.

Consanguinity↗
PubMed1978

Cluster of cystic fibrosis cases in a limited area of Brittany (France).

Cystic fibrosis in the northern sector of the French "département" of Finistère is 1:1787 live births. Within this sector a concentration of the disease was found in a small area. The minimal frequency in this area, from 1946 to 1972, was calculated as 1 per 377 live births, the gene frequency being 0.0515. Genealogic analysis, going back to the beginning of the 18th century, showed a relationship between 8 of the 10 families to which the patients belonged. The origin of the deleterious genes may be explained by a least five primary ancestral couples living in the 18th century. Random drift is the most probable explanation for the concentration of cystic fibrosis in this region.

Cystic Fibrosis↗
PubMed1978

Consanguinity in multifactorial inheritance. Application to data on congenital glaucoma.

The increase of parental consanguinity in multifactorial inheritance is evaluated by calculating the expected incidence of affected children whose parents are first cousins, using several values, namely for condition frequency and heritability of liability. This increase is compared to the expected increase in recessive inheritance, when one or more loci are involved. The method is illustrated by examples of recessive and multifactorial conditions and applied, as a test of discrimination between different modes of inheritance, to data on congenital glaucoma.

Consanguinity↗
PubMed1978

[Genetics and human cancers: methods of study (author's transl)].

The role of hereditary factors in the etiology of cancer is difficult to prove. However, one may precise a hereditary relationship in those cancers which are either transmitted as a monofactorial trait, or secondary to a hereditary disease, or linked to a genetic marker. Most often, it is necessary to fall back on familial investigations, which may sometimes indicate an excess of familial cases. However, a familial concentration of certain cancers may also be due to hereditary factors, as well as to a common environment.

Chromosome Aberrations↗