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Biomedical subjects

J Farrell

Publications and source records attributed to J Farrell.

At least 19 recordsLinked to original sources

A classification for dry eyes following comparison of tear thinning time with Schirmer tear test.

In a double-blind study a non-invasive method of examining the stability of the precorneal tear film was used to record tear thinning time on a population of 34 independently diagnosed dry eye patients. The results were compared with those for tear output, as inferred from the standard Schirmer tear test, and a correlation coefficient of 0.20 determined. The mean tear thinning time and Schirmer results for the population sample were 6.87 +/- 2.97 sec, and 5.62 +/- 5.69 mm wetting in 5 min, respectively. From a plot of tear thinning time against Schirmer a simple classification for dry eyes can be made. A Type A with normal tear stability and low output accounting for 14.70% of the dry eyes. A Type B with low tear stability and normal output, also accounting for 14.70% of the dry eyes. A Type C with low stability (less than 9.84 sec), and low output (less than 11.31 mm wetting in 5 min) accounting for 70.60% of the dry eyes.

Adult

Outbreak of adenoviral infections in a long-term paediatric facility, New Jersey, 1986/87.

During an 8-week period in the winter of 1986-87, there were 11 deaths from an adenovirus infection (case fatality rate = 39%, 11/28) in a long-term care paediatric facility in southern New Jersey. Among the 61 resident children, all with severe congenital and/or acquired disabilities, 28 developed a febrile respiratory illness compatible with adenovirus infection [attack rate (AR) = 46%]. Patients with tracheostomies were three times as likely to become ill [relative risk (RR) = 3.2, 95% confidence intervals (CI) = 1.8-5.6]. Twenty-three members of the staff had a similar febrile illness (AR = 22%, 23/106); nurses were more likely to be ill than other staff (RR = 3.0, 95% CI = 1.1-11.4). Adenovirus 7 was isolated from four of the case patients and adenovirus 1 from one. The findings suggest prolonged transmission between patients and nursing staff with lack of cohorting of ill patients probably contributing to the prolongation of the outbreak. This investigation indicates that adenoviral outbreaks, although rare, can have a high mortality in severely disabled children, and that future outbreak investigations should examine the use of vaccines or antiviral agents to reduce mortality and for outbreak control.

Adenovirus Infections, Human

Granulomatous orchitis. Review of 15 cases.

Granulomatous orchitis is a rare lesion of the testis which can clinically simulate malignancy. The clinical, radiological and pathological features of 15 patients are presented and discussed.

Adult

An unusual case of adrenal cortical carcinoma.

We describe a case of non-functioning adrenal cortical carcinoma, which recurred 16 years after surgical adrenalectomy. In addition, the patient was successfully treated for two anatomically separate and histologically different, primary malignant tumours. This case highlights the importance of lifelong follow-up after apparently curative surgical excision of an adrenal tumour.

Adrenal Cortex Neoplasms

Measurement of diffusing capacity in pulmonary embolism.

Pulmonary function tests were carried out in 20 consecutive patients with pulmonary embolism (PE), diagnosed on the basis of a positive ventilation-perfusion lung scan carried out within 72 h of admission. Changes in forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and arterial blood gas tensions were too variable to be helpful diagnostically. In contrast, transfer factor (diffusing capacity) of the lung (TLCO) was significantly reduced in all cases and, in spite of a period of anticoagulation, tended to remain subnormal during a follow-up period of up to 3 years. Lung scans, however, tended to return to normal within 3 months of the incident. Thus, a reduction of TLCO to below 75% of the predicted normal was found in all cases with abnormal lung scans and such measurements provide a useful and simple screening test for PE; a normal TLCO would effectively exclude such a diagnosis. The failure of TLCO to return to normal in the majority of cases suggests persistence of the underlying physiological defect, in spite of normalization of symptoms and lung scans following anticoagulation.

Adult

An innovative method of processing short-term inpatient groups.

Inexperienced group leaders can benefit from using a system to process groups. A system or model can help to reduce anxiety. It can help group leaders make connections between group behavior and theoretical concepts, and move the group toward its goal. The author presents such a system. This one provides a specific recording format and step-by-step guidelines for organizing and interpreting the collected data.

Group Processes

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Dentistry