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Biomedical subjects

J Farber

Publications and source records attributed to J Farber.

43 records · Page 3Linked to original sources
PubMed1969

Bullfrog (Rana catesbeiana) ventilation: how does the frog breathe?

Two short-term cyclic events, buccal oscillations and ventilatory cycles, occur in the bullfrog's respiration. Dutring ventilation the frog fills the buccal cavity with air, then blows the pulmonary contents through the buccal cavity, and finally closes the nostrils while pumnping the buccal contents into the lungs. The pulmonary efflux streams by the buccal contents with minimal mixing, and relatively pure air is pumped into the lungs. Buccal oscillations serve mainly to flush out the buccal cavity between ventilatory cycles.

Air↗
PubMedDate not supplied

A three-part study to investigate the incidence and potential etiologies of tadalafil-associated back pain or myalgia.

The potential mechanisms underlying back pain and/or myalgia experienced by men taking tadalafil were investigated. An integrated analysis of 10 placebo-controlled tadalafil clinical trials (N=1846) showed that the incidence of back pain and/or myalgia was 9.4% in patients receiving tadalafil 10 mg (N=394), 8.3% in patients receiving tadalafil 20 mg (N=883) and 3.7% in placebo-treated patients (N=569). One (0.3%) patient receiving tadalafil 10 mg, six (0.7%) patients receiving tadalafil 20 mg, and no patients receiving placebo discontinued treatment due to back pain and/or myalgia. In a prospective study in healthy volunteers, no substantial changes were observed in laboratory markers indicative of inflammation or muscle damage, and tadalafil did not affect renal plasma flow nor produce lumbar or gluteal myositis by positron emission tomography scan or magnetic resonance imaging. Although the mechanism of back pain and/or myalgia remains unknown, these events appear to be self-limiting and a general effect of phosphodiesterase 5 inhibition.

Adolescent↗
PubMedDate not supplied

Long-term follow-up of hip subluxation in cerebral palsy patients.

Spastic subluxation of 64 hips in 45 patients with cerebral palsy (CP) was reviewed in a 19-year follow-up. Varus osteotomy prevented dislocation in all patients. All nine hips that later dislocated were in quadriplegic patients who had not received treatment or who had had muscle releases. Dislocated hips had the most degenerative arthritis, pain, and the least movement. Subluxated hips also had more degenerative arthritis but approximately the same level of pain as reduced hips.

Adolescent↗