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Biomedical subjects

J Faivre

Publications and source records attributed to J Faivre.

At least 271 records · Page 15Linked to original sources
PubMed1984

[Chronic urticarial eruption with arthritis, papillary edema, and meningoencephalitis of childhood onset].

The authors report on a case of chronic urticarial eruption since infancy in a man who is now 27-year-old; the association of numerous chronic symptoms, principally meningo-encephalitis, polyarthritis, hepato-spleno-adenomegaly allows the authors to compare this case to those described by Prieur and Griscelli in 1981 and 16 others cases found in literature. It appears as a "systemic disease" without biological or immunological markers; it might belong to the group of chronic normocomplementemic vasculitis.

Adult↗
PubMed1984

[Colorectal cancer in the Department of Côte-d'Or].

The present study is based on the data of the digestive tract cancer registry set up for the French department of Cote d'Or (population 455,727). During 1976-1980, 581 colon cancers and 489 rectal cancers were diagnosed. They represent 47 per cent of all recorded gastro intestinal cancers. The annual adjusted incidence rates for colon cancers, adjusted to the world population were 17.5 for males, 13.3 for females. The corresponding rates for rectal cancers were 18.2 for males, 9.7 for females. These rates rank among the high rates found in North America and Western Europe. They are particularly high for rectal cancers. There was an urban predominance for colon cancer in males. Among colorectal cancers, 75 per cent were located in the rectum or sigmoid. Sixty-one per cent of the cases of large bowel cancer underwent curative surgery. The overall 5-year survival rate was 30.0 per cent for colon cancer, 27.4 per cent for rectal cancer. After curative surgery the 5 year survival rates were respectively 53.7 per cent and 47.8 per cent. The most important determinant of survival was the pathological stage of the tumour. These results underline the fact that by its frequency and its severity, colorectal cancer represents a major cancer problem.

Adult↗
PubMed1983

Cancer registries: their interest and practical problems.

Cancer registries record all new cases of cancer within the population they survey. Thus they provide accurate regional measurements of cancer morbidity and mortality and their geographical distribution. This form of epidemiology allows the study of regional variations and alterations with the passage of time. It also allows the study of environmental factors that might cause cancer. The work of the French regional cancer registries is described to illustrate these points. The problems of running a cancer registry are also set out and suggestions are made for future organization. The statistics gathered by such registries indicate possible methods for the early detection and treatment of some cancers and provide evidence of the long-term effects of all kinds of therapy. The socio-economic aspects of cancer can also be measured by the registry, thus providing valuable data for use in the planning of health care in any community.

Epidemiologic Methods↗
PubMed1983

Somatostatin in peptic ulcer bleeding--results of a double-blind controlled trial.

The aim of this work was to assess the usefulness of somatostatin in acute peptic ulcer bleeding. Sixty-four patients with endoscopic evidence of duodenal ulcer bleeding completed a double-blind trial to compare the effectiveness of somatostain (6 mg i.v. per day) with that of placebo; incidence of treatment failure (i.e., rebleeding or persistent haemorrhage) was not different in the somatostatin and in the placebo groups (respectively 24% and 23%). Because the efficacy of cimetidine had previously been demonstrated in gastric ulcer bleeding, somatostatin was tested against cimetidine (1.6 g per day) in 50 patients with gastric ulcer haemorrhage. The treatment failed to control bleeding in 15% of somatostatin and in 17% of cimetidine treated subjects (n.s.). Both treatments were well tolerated and blood requirements were not different in the trial groups. These results show that the efficacy of somatostain in peptic ulcer bleeding is not different from placebo in duodenal ulcers and not different from cimetidine in gastric ulcers.

Age Factors↗
PubMed1983

[Case of early hydrocephalus in mucopolysaccharidosis type 1].

One mucopolysaccharidosis I-H (Hurler's Syndrome) found in 3 months infant, was complicated with an hydrocephalus at the age of 5 months. If macrocephaly is known in several genetic inborn errors of metabolism, specially in the different mucopolysaccharidosis, hydrocephalus is quite more rare. It is probably communicating and due to accumulation of storage material in the piaarachnoid causing an impairment in CSF absorption. It occurs in the evolution of the disease and the reported cases concern only older children; our case is special by the early beginning of hydrocephalus.

Humans↗
PubMed1983

[Postoperative radiotherapy of rectal cancer. A retrospective study within the population of the Department of Côte-d'Or].

The registry of digestive cancer set up for French department of Cote d'Or (455,727) collects all newly diagnosed cases of rectal cancers occurring among residents. It allows to study the place and the results of postoperative radiotherapy among Dukes' B and C patients. From 1976 to 1980 postoperative radiotherapy was theorically indicated in 177 patients. Ten of the 95 Dukes' B patients (10.5 p. 100) and 26 of the 82 Dukes' C patients (31.7 p. 100) were actually irradiated postoperatively (P less than 0.001). All of the studied variables (i.e. age, sex, operative procedure, number of lymph nodes containing metastases) were not statistically different between the two groups of patients. The mean size of the tumor was slightly larger in the group treated with radiotherapy. Minor reactions after radiotherapy were frequent. There were two major complications: a small bowel obstruction and a perineal abscess with chronic fistula. The probability of local recurrence was correlated with the stage of disease and the mode of treatment. Dukes' C patients showed a 5-year local recurrence rate of 30 p. 100 after surgery alone and of 0 p. 100 after surgery and postoperative radiotherapy (P less than 0.001). The corresponding 5-year local recurrence rates for Dukes' C patients were 75 p. 100 and 26 p. 100 (P less than 0.01). The risk of local recurrence increased regularly during the 4 years following surgery. The modes of treatment did not influence the risk of developing distant metastases. Survival curves were the same for patients treated with surgery only and patients treated with combined therapy. The only difference was the 5-year survival rate of Dukes' C patients: 25 p. 100 after surgery and postoperative radiotherapy and 12 p. 100 after surgery alone but the difference was not statistically significant.

Female↗
PubMed1982

[Factors of early prognosis in medically treated haemorrhages of upper gastrointestinal tract in cirrhotic patients. Statistical study (author's transl)].

In order to define immediate criteria of prognosis for patients with cirrhosis, hospitalized in emergency for upper gastrointestinal tract haemorrhage, 164 cases of haemorrhages medically treated were reviewed. A prognostic study of each variant points to the clinical, endoscopic and biological data connected with death. That study illustrates the prognostic value of traditional data. Patients who died within the first 30 days had a significantly higher incidence of hepatic encephalopathy, hematemesis, ascites, low blood pressure, bleeding oesophageal varices during endoscopy, hypoprothrombinemia, hyperbilirubinemia. Those who survived had a significantly higher incidence of aspirin intake, numerous haemorrhages, good state of health, non bleeding peptic ulcer. Several series of multivariant analysis: multiple regression and linear discrimination, differing from one another in variates were done. They have allowed identification of 11 variables used in establishing a prognostic index. In the series studied, it gives an 87% probability of correct differentiation. Such an index allows an objective estimate of the value and limits of a group of patients in which the efficiency of other treatments could be tested in controlled trials.

Adult↗
PubMed1981

Cancer of the esophagus. An incidence study of Côte d'Or (Burgundy).

The registry of digestive cancer set up for the French department of Côte d'Or (455, 727) enables a morbidity study about esophageal cancer to be made among residents. The crude animal incidence rate was 16.7/100,000 for males and 1.2/100,000 for females. Corresponding age-standardized rates were 13.2 and 0.5. The sex ratio is extremely high. Among other cancer registries Côte d'Or is in the intermediate range for males, and in the low range for females. 40% of tumors were in the middle third, 37% in the lower third, and 23% in the upper third. Most cancers were squamous cell carcinomas (94%). The risk of an associated aerodigestive tract tumor is important (16%). 10% of patients were operated upon for cure, 53% had radiotherapy. The 1 year crude survival rate was 25%.

Adenocarcinoma↗
PubMed1981

[Factors of early prognosis in medically treated haemorrhages of upper gastrointestinal tract in cirrhotic patients. Statistical study (author's transl)].

In order to define immediate criteria of prognosis for patients with cirrhosis, hospitalized in emergency for upper gastrointestinal tract haemorrhage, 164 cases of haemorrhages medically treated were reviewed. A prognostic study of each variant points to the clinical endoscopic and biological data connected with death. That study illustrates the prognostic value of traditional data. Patients who died within the first 30 days had a significantly higher incidence of hepatic encephalopathy, hematemesis, ascites, low blood pressure, bleeding oesophageal varices during endoscopy,. hypoprothrombinemia, hyperbilirubinemia. Those who survived had a significantly higher incidence of aspirin intake, numerous haemorrhages, good state of health, non bleeding peptic ulcer. Several series of multivariant analysis : multiple regression and linear discrimination, differing from one another in variates were done. They have allowed identification of 11 variables used in establishing a prognostic index. In the series, it gives an 87% probability of correct differentiation. Such an index allows an objective estimate of the value and limits of a group of patients in which the efficiency of other treatments could be tested in controlled trials.

Adult↗
PubMed1980

Incidence of digestive tract cancers in a well defined population in France.

A systematic registration of mortality and morbidity from digestive tract cancers was started in January 1976 in the French department of Cote d'Or (population 455,727). In the course of 3 years 1356 newly diagnosed cases were recorded. In males cancer of the rectum is the most common digestive tract cancer, coming before cancer of the stomach and cancer of the colon. In females cancer of the colon prevails over cancer of the rectum and cancer of the stomach. The survey allows comparison with the incidence rate of digestive cancers in other countries. Results of treatment underline the lateness of diagnosis.

Colonic Neoplasms↗