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Biomedical subjects

J F Zilva

Publications and source records attributed to J F Zilva.

At least 19 recordsLinked to original sources
PubMed1978

The origin of the acidosis in hyperlactataemia.

Anaerobic glycolysis produces lactate, ATP, and water but there is no net change in the number of hydrogen ions: it does not produce lactic acid. The acidosis usually associated with hyperlactataemia is caused by hydrolysis of the ATP, with release of hydrogen ions. By contrast, ATP turnover by aerobic mechanisms is not acidifying because the released hydrogen ion is reutilised as more ATP is formed. Gluconeogenesis from lactate does not utilise hydrogen ions directly--in fact, it produces them. The associated net H+ utilisation is caused by the aerobic generation of the ATP and GTP required to drive glycolysis in reverse. It is suggested that only by understanding these important biochemical facts can the clinician found his diagnosis and treatment on a firm, rational basis.

Acidosis↗
PubMed1977

The anion gap.

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Acid-Base Imbalance↗
PubMed1977

The anion gap.

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Acidosis↗
PubMed1975

SI units: how systematic and how international are they?

Despite the fact that the use of SI units should standardize the reporting of results in chemical pathology, there is still considerable confusion in some areas about the accepted conventions. This confusion is particularly rife in reporting results of thyroxine, and, to a lesser extent, of lipid assays.

Blood Chemical Analysis↗
PubMed1968

Determination of uric acid levels in uraemia by enzymatic and colorimetric techniques.

Serum uric acid levels were determined by specific and non-specific methods in uraemia in order to investigate the correlation between non-specific chromogen and serum urea level. The correlation was moderate and the magnitude of the non-specific chromogen was smaller than had been reported previously. The ratio [Formula: see text] urate was found to be 0.85 in both acute and chronic renal failure, a ratio very similar to that previously reported for normal and gouty subjects. In chronic renal failure the true uric acid level is correlated with urea level and there is a suggestion that serum uric acid levels in chronic renal failure are lower for a given urea value than in acute renal failure.

Acute Kidney Injury↗