Are laws prohibiting ownership of pit bull-type dogs legally enforceable?
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Animals↗
Biomedical subjects
J F Wilson
Publications and source records attributed to J F Wilson.
Channel-consistency following unilateral stroke: an examination of patient communications across verbal and nonverbal domains.
One way in which the dyadic communicative process can go awry is for one or both parties to send channel-inconsistent communications - communications in which the verbal and nonverbal elements are not matched in emotional valence (e.g., uttering positive words with a frown). We hypothesized that unilateral stroke patients would be likely to send such messages. Given the verbal impairments typically associated with left hemisphere damage (LHD), e.g., agrammatism, and the nonverbal impairments typically associated with right hemisphere damage (RHD), we expected LHD and RHD patients to send messages in which the impaired channel was perceived as inconsistent with the unimpaired channel. Ten LHD, 11 RHD and six normal control patients were videotaped while engaging in social interaction. Observers made judgments about the valence of the patients' (1) words (based on transcripts of the interactions), and (2) facial expressions (based on soundless videos of the interactions). Analysis of word-face difference scores revealed a significant linear trend, with messages of LHD patients judged more positive in facial expression than in verbal content, messages of RHD patients judged more positive in verbal content than in facial expression, and messages of control patients judged channel-consistent (similar in valence across facial and verbal channels).
Communication↗
Y chromosomes traveling south: the cohen modal haplotype and the origins of the Lemba--the "Black Jews of Southern Africa".
The Lemba are a traditionally endogamous group speaking a variety of Bantu languages who live in a number of locations in southern Africa. They claim descent from Jews who came to Africa from "Sena." "Sena" is variously identified by them as Sanaa in Yemen, Judea, Egypt, or Ethiopia. A previous study using Y-chromosome markers suggested both a Bantu and a Semitic contribution to the Lemba gene pool, a suggestion that is not inconsistent with Lemba oral tradition. To provide a more detailed picture of the Lemba paternal genetic heritage, we analyzed 399 Y chromosomes for six microsatellites and six biallelic markers in six populations (Lemba, Bantu, Yemeni-Hadramaut, Yemeni-Sena, Sephardic Jews, and Ashkenazic Jews). The high resolution afforded by the markers shows that Lemba Y chromosomes are clearly divided into Semitic and Bantu clades. Interestingly, one of the Lemba clans carries, at a very high frequency, a particular Y-chromosome type termed the "Cohen modal haplotype," which is known to be characteristic of the paternally inherited Jewish priesthood and is thought, more generally, to be a potential signature haplotype of Judaic origin. The Bantu Y-chromosome samples are predominantly (>80%) YAP+ and include a modal haplotype at high frequency. Assuming a rapid expansion of the eastern Bantu, we used variation in microsatellite alleles in YAP+ sY81-G Bantu Y chromosomes to calculate a rough date, 3,000-5,000 years before the present, for the start of their expansion.
Africa, Southern↗
Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans.
We sequenced the genomic region containing the human Y-linked zinc finger gene (ZFY). Comparison of ZFY to the related region on the X chromosome (ZFX) and to autosomal sequences reveals a significant accumulation of transposable elements on the sex chromosomes. In addition, five times as many retroviruslike elements (RLEs) are present in the ZFY region as in the ZFX region. Thus, transposable elements accumulate more rapidly on the sex chromosomes, and the insertion of RLEs may occur more frequently in the male than in the female germ line. When the accumulation of substitutions in Alu elements was analyzed, it was found that the Alu elements at the Y-chromosomal locus diverged significantly faster than those at the X-chromosomal locus, whereas the divergence of autosomal Alu elements was intermediate. The male-to-female mutation rate ratio was estimated to be 2.5.
Alu Elements↗
Specialty choices of students who actually have choices: the influence of excellent clinical teachers.
PURPOSE: To determine the influence of the quality of attending physicians and residents on the specialty choices of excellent medical students, who actually have a broad choice of specialties. METHOD: In 1993-94 and 1994-95, 169 third-year students at the University of Kentucky College of Medicine were randomly assigned to two one-month rotations on general medicine inpatient wards. At the end of each rotation, the students confidentially evaluated the attending physician and the supervising resident (different for each rotation) with whom they had worked. Data were collected for 62 attending physicians and 89 residents. The authors analyzed the influences of the "best" and "worst" clinical instructors (those rated in the top and the bottom 20% by all students with whom they had worked over the two years) on "excellent" medical students (the 52 students whose USMLE I scores were in the top 30% of their class). RESULTS: Using regression approaches from the general linear model, the authors found that independent predictors of internal medicine residency choice for excellent medical students were exposure to highly rated internal medicine attendings (p = .02) and residents (p = .03). Nine of 29 (30%) of the excellent students who worked with a "best" medicine clinical instructor chose an internal medicine residency, while none of the 23 excellent medical students who did not work with a "best" medicine clinical instructor did so. The authors found no correlation in students' ratings of their pairs of attendings and residents, suggesting that rater bias did not explain the results. CONCLUSION: Better medical students who work with the best internal medicine attending physicians and residents in their internal medicine clerkship are more likely to choose an internal medicine residency.
Career Choice↗
Six-year documentation of the association between excellent clinical teaching and improved students' examination performances.
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Achievement↗
Landmarks in route learning by girls and boys.
Previous research on route learning has shown that men learn routes faster and with fewer errors than women. The same patterns have also been found for girls and boys. In this study, 19 children of ages 5 to 6 years, 26 children of ages 7 to 9 years, and 22 children of ages 10 to 12 years were presented a route learning task. The children were randomly assigned to either the Landmark group in which they were required to learn a route on a map that included landmarks or the No-landmark group in which they learned a route on a map without landmarks. Significant main effects were found for age and sex. Older children learned the route faster and with fewer errors than younger children. Boys made significantly fewer errors and took less time and fewer trials to reach criterion in learning the route regardless of whether landmarks were present or not. The role of landmarks in route learning needs to be further clarified.
Attention↗
Effects of low doses of caffeine on aggressive behavior of male rats.
To date, the effect of low doses of caffeine on aggression has not been systematically examined. Doses of caffeine greater than 30 mg/kg appear to reduce social interaction and aggression in all species studied. In a double blind study of the effects of low doses of caffeine on aggression, rats were housed four per cage, and aggressive behavior against an intruder was recorded during baseline and following administration of 2.5, 5, 10, and 20 mg/kg caffeine. Aggressive behavior was significantly increased following administration of the higher doses of caffeine. Doses of 5, 10, and 20 mg/kg caffeine all were effective in increasing pushing behavior, whereas doses of 5 and 10 mg/kg were most effective in increasing boxing behavior, and a dose of 10 mg/kg was significantly more effective than other doses in increasing chasing and roll-tumble-bite behaviors. Based on these results and other published reports, the inverted-U shaped dose-dependent effect of caffeine on aggression appears to apply, with aggressive behavior being most elevated following doses of 5-20 mg/kg caffeine, less elevated following 2.5 mg/kg or 30 mg/kg, and significantly reduced with doses above 40 mg/kg and at doses below 2.5 mg/kg.
Aggression↗
Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation.
BACKGROUND: The cardiovascular complications of Marfan syndrome arise due to alterations in the structural and functional properties of fibrillin, a constituent of vascular connective tissues. Fibrillin-containing microfibrils are closely associated with arterial endothelial cells, indicating a possible functional role for fibrillin in the endothelium. Plasma concentrations of endothelial cell products are elevated in Marfan subjects, which indirectly indicates endothelial dysfunction. This study directly assessed flow- and agonist-mediated endothelium-dependent brachial artery reactivity in Marfan subjects. METHODS AND RESULTS: In 20 Marfan and 20 control subjects, brachial artery diameter, blood flow, and blood pressure were measured by ultrasonic wall tracking, Doppler ultrasound, and photoplethysmography, respectively. Measurements were taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the upstream brachial artery) and after sublingual administration of the endothelium-independent vasodilator nitroglycerin. In 9 Marfan and 6 control subjects, the above parameters were also assessed during intra-arterial infusions of acetylcholine and bradykinin (agonists that stimulate NO production) and NG-monomethyl-L-arginine (L-NMMA, an inhibitor of NO production). Flow-mediated responses differed markedly between Marfan and control subjects (-1.6+/-3.5% versus 6. 50+/-4.1%, respectively; P<0.0001), whereas nitroglycerin produced similar vasodilation (14.2+/-5.7% versus 15.2+/-7.8%; P=NS). Agonist-induced vasodilation to incremental intra-arterial infusions of acetylcholine and bradykinin were not significantly different between Marfan and control subjects, and intra-arterial L-NMMA produced similar reductions in brachial artery diameter in both groups. CONCLUSIONS: These data demonstrate impaired flow-mediated but preserved agonist-mediated endothelium-dependent vasodilation in Marfan subjects and suggest preservation of basal NO release. Selective loss of flow-mediated dilation suggests a role for fibrillin in endothelial cell mechanotransduction.
Acetylcholine↗
Preschoolers' mid-afternoon snack intake is not affected by lunchtime food consumption.
The purpose of this study was two-fold: to determine the contribution of mid-afternoon snack intake to total daily energy intake and to examine the effect of lunchtime eating on subsequent snack intake in preschool children. Lunch energy intake was manipulated by varying the energy content of the milk beverage served at lunch. Mid-afternoon snack consumption in 135 children, aged 18-66 months, offered chocolate-flavored or plain milk at lunch. Nutritious mid-morning snacks, lunches and mid-afternoon snacks were served on a rotating schedule 2 days per week for 12 weeks. The children were allowed to consume as much as they wanted of any food items served at lunch or snacktime, including the beverages. Although the children consumed significantly more energy during lunchtime meals at which sucrose-sweetened chocolate milk was served, their intake of the mid-afternoon snack was not affected by the type of milk beverage served or the energy consumed at lunch. All children consumed between 20 and 25% of their daily energy requirement at lunch and between 8 and 22% of their daily energy requirement during the mid-afternoon snack. Snacks are an important source of energy for young children, especially those under three years of age.
Appetite↗
Patterns of child abuse and neglect associated with chronological age of children living in a midwestern county.
OBJECTIVE: The main objective of the study was to investigate the relationship between age of the very young victim and the type of abuse perpetrated against that victim. A secondary objective was to examine gender and racial differences in child abuse and neglect in children between the ages of birth and 7 years. METHOD: Archived data for all cases of substantiated abuse of children for the years of 1990-1996 inclusive were retrieved from a data bank at a county children services department (N = 876). Chi-square analyses were used to determine age, gender, and racial differences in child abuse and neglect in children 0 to 7 years of age. RESULTS: Neglect was the most common form of primary substantiated abuse recorded for this population of children under the age of 7 years, although the incidence of neglect decreased as chronological age of the child increased. Sexual abuse increased in occurrence as the children got older. Girls were more likely to be victims of sexual abuse than boys. No significant age differences were observed for physical abuse or for emotional abuse, and no racial differences were detected for any of the four types of abuse examined. CONCLUSIONS: Although the findings of this study are in agreement with those of previously published reports, there is some question as to whether archived data are an accurate reflection of actual patterns of maltreatment occurring in very young children or whether they represent the types of abuse that are subjectively identified and reported by authorities.
Age Factors↗
Management of axillary lymph nodes in breast cancer: a national patterns of care study of 17,151 patients.
OBJECTIVE: To determine the rates of axillary lymph node dissection (ALND) and axillary irradiation (AI) in patients with breast cancer and to identify the factors influencing them. SUMMARY BACKGROUND DATA: Routine performance of ALND in the treatment of breast cancer has become controversial. AI has been proposed as an alternative to ALND, and it has been suggested that AI in addition to ALND may decrease local failure in high-risk patients. METHODS: A joint study was conducted by the Commission on Cancer of the American College of Surgeons and the American College of Radiology. A total of 17,151 patients with stage I and II breast cancer treated at 819 institutions in 1994 were studied. RESULTS: A total of 15,992 patients underwent ALND (93%). The mean ages of patients who did and did not undergo ALND were 60.4 and 73.0 years. Univariate analysis demonstrated significantly decreased rates of ALND for women age 70 or older (86% vs. 97%), patients with clinical T1 a tumors (81% vs. 93%), grade I histology (90% vs. 95%), and patients with favorable tumor types (88% vs. 94%). The ALND rate did not vary between palpable and nonpalpable tumors. Multivariate analysis of variables affecting the rate of ALND identified type of surgery, age, tumor size, histology, and payer status as significant. A total of 889 patients received AI. Patients not undergoing ALND were more likely to receive AI (10% vs. 5%). A total of 1.6% of patients with no lymph node metastasis underwent AI, 8.9% of those with one to three positive nodes underwent AI, 24.0% of those with four to nine positive lymph nodes underwent AI, and 29.9% of those with > or = 10 positive lymph nodes underwent AI. Multivariate analysis of variables affecting the proportion of patients who received AI and had undergone ALND identified nodal status and type of surgery as significant. CONCLUSIONS: Axillary lymph node dissection continues to be routinely applied in the treatment of breast cancer, and AI remains underused in patients at high risk for local regional relapse.
Adult↗
A retrospective review of medical school admission files of academically at-risk matriculants.
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Adult↗
Academic and noncognitive factors affecting placement of medical school applicants on an alternate list.
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Decision Making↗
Housestaff workload and procedure frequency in the neonatal intensive care unit.
OBJECTIVE: To investigate the association of clinical workload and the decision to perform procedures on infants in the neonatal intensive care unit (NICU). DESIGN: Prospective cohort study over one academic year, observing infants exposed to housestaff working under various levels of clinical workload. SUBJECTS: All 31 housestaff rotating on the NICU service during the academic year 1993 to 1994 were observed. A total of 785 infants were admitted to these housestaff. SETTING: One academic Level III intensive care nursery. MEASUREMENTS AND MAIN RESULTS: Clinical workload was operationalized as number of NICU infants cared for by the individual houseofficer on-call each night. The procedures of interest were number of umbilical artery catheters (UACs), intubations, lumbar punctures (LPs), and peripheral phlebotomy performed by the houseofficer on-call. Using multiple linear regression approaches, controlling for the average severity-of-illness of each of the NICU infants, the experience and residency program of the houseofficer on-call, and the individual attending, we found that increased clinical workload (number of NICU infants) resulted in a significantly greater probability that an admitted infant received an umbilical artery catheter (p = .02), but resulted in less probability that any NICU infant received a lumbar puncture (p = .0001) or peripheral phlebotomy (p = .0002). The decision to intubate an infant was not affected by the workload in the NICU. CONCLUSIONS: The clinical workload of housestaff in the NICU can affect decisions to perform procedures on infants in the NICU. For equivalently severely ill infants, there is a greater chance of receiving a UAC and less chance of being phlebotomized or receiving an LP when workload is high. Attending neonatologists need to be sensitive to possible effects of workload on patient care in the NICU.
Analysis of Variance↗
Precision and accuracy of the measurement of antiepileptic drugs in South Africa.
The accuracy and the precision with which a drug concentration is quantified in the blood has a significant impact on the therapeutic drug monitoring (TDM) of the drug. In the absence of a system of accreditation of laboratories in South Africa, this study was designed to compare the accuracy and the precision of the measurement of antiepileptic drugs by 24 South African laboratories with those of non-South African laboratories that participate in the United Kingdom National External Quality Assessment Scheme (UKNEQAS). Three test samples, containing a range of concentrations of phenytoin, valproate, carbamazepine, and phenobarbitone spiked into newborn calf serum were distributed to participating laboratories, which were asked to measure the serum concentrations using their routine assay method. Coefficients of variation were used to assess precision of measurements, and the percentage difference of the consensus mean from the spike value was used as an assessment of accuracy. There was comparable precision in the measurements for both the South African and the non-South African groups. However, there appeared to be a difference in the accuracy of measurement between the two groups. It was noted that the majority (77%) of the South African laboratories used the Abbott fluorescence polarization immunoassay (FPIA) with TDx analyzers (Abbott Laboratories, Abbott Park, IL, USA). Further analysis of the results of the South African and UKNEQAS subgroups using the FPIA technique showed a reduction in statistic bias, suggesting that part of the explanation for the statistic difference in the accuracy may be an intertechnique bias related to the use of a nonhuman matrix for sample preparation. Additional studies are required to determine other causes for the statistic differences in accuracy. However, the differences in accuracy are unlikely to be of clinical significance.
Animals↗
Evaluation of detection techniques and laboratory proficiency in testing for drugs of abuse in urine: an external quality assessment scheme using clinically realistic urine samples. Steering Committee for the United Kingdom National External Quality Assessment Scheme for Drugs of Abuse in Urine.
Techniques for the detection of drugs of abuse were compared using data from 43 urine samples distributed by the United Kingdom National External Quality Assessment Scheme. Drug mixtures simulated clinical specimens and contained drugs at the following median concentrations: amphetamine 1.6 mg/L (six samples), barbiturates 1.7 mg/L (six samples), benzoylecgonine 0.6 mg/L (eight samples), benzodiazepines 1.6 mg/L (four samples), cannabinoids 59 micrograms/L (four samples), methadone 1.7 mg/L (11 samples) and morphine 1.7 mg/L (seven samples). Significant lack of sensitivity was demonstrated for one or more analytes by all chromatographic techniques, including gas chromatography with mass spectrometry. Commercial immunoassay kits exhibited higher sensitivity, though some assays performed significantly less well than others. Significant non-specificity was also a greater problem for chromatographic techniques compared with immunoassays in samples containing therapeutic agents not structurally related to abused compounds. In the presence of therapeutic interferents structurally related to the test compounds, false positive reports for illicit materials increased from < 1% to > 6%. Use of confirmatory tests significantly reduced the incidence of both false negative and false positive reports.
Evaluation Studies as Topic↗
Sex differences in route learning by children.
Differences between men and women have been reported with respect to route-learning, but sex differences in children on these and related tasks have not been found. In this study, 51 children ages 5 to 12 years were required to learn a route on a map to criterion and then asked to recall landmarks on that route. Boys made significantly fewer errors and took less time and fewer trials to reach criterion in learning the route, and girls recalled more landmarks than boys. Significant main effects for age were also noted on all measures of route learning and landmark recall. These results suggest that the patterns of route learning that have been ascribed to women and men are present in girls and boys.
Age Factors↗