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Biomedical subjects

J F Williamson

Publications and source records attributed to J F Williamson.

At least 19 recordsLinked to original sources
PubMed1995

A secondary air kerma strength standard for Yb-169 interstitial brachytherapy sources.

Ytterbium-169 (169Yb) is a promising new intermediate low-energy isotope for interstitial implantation. To date, no air kerma strength (SK) standard for this source exists that can serve as a sound foundation for comparing various dose measurements and theoretical calculations. We have solved this problem by adapting the free air measurement technique of Goetsch et al, originally developed for 192Ir. Using a 100 cm3 spherical ion chamber with NIST traceable external beam calibrations in a free air geometry, we have measured the air kerma strength of six different source batches (two type 6 batches, three type 8 batches, and one experimental high-intensity source). Room scatter corrections, derived from an empirical fit to the data (following Goetsch et al) and/or directly by Monte Carlo simulation, yielded identical results with a reproducibility of 1%. The ratio [SK/Avendor] of measured SK to the vendor's contained activity assay averaged 1.554 cGy cm2 mCi-1 h-1 (0.0420 microGy m2 MBq-1 h-1), in conflict with the expected value of 1.34 (0.0362), derived from Monte Carlo calculations. The measured [SK/Avendor] for the type 8 seeds varies by as much as 10% whereas the SK/dose calibrator reading ratio varies by no more than 0.3%, suggesting that the reproducibility of Avendor is relatively poor. These discrepancies may help explain the variation (as large as 28%) in published dose rate constants for 169Yb.

Air↗
PubMed1995

Monte Carlo aided dosimetry of the microselectron pulsed and high dose-rate 192Ir sources.

Despite the large number of single-stepping source pulsed and high dose-rate (HDR) remote after-loading devices in clinical use, the published literature contain little data characterizing dose-rate distributions around the high-intensity (4 x 10(3)-4 x 10(4) microGy m2h-1) 192Ir sources currently used in these devices. We have used the Monte Carlo method to calculate complete two-dimensional dose-rate distributions about the most widely used high dose-rate source design, as well as the Nucletron pulsed dose-rate (PDR) 192Ir source. A Monte Carlo photon transport code, incorporating the detailed internal geometry of the source, was used to calculate the dose rate per unit air-kerma strength in water medium on the transverse bisecting axis over the 0.15-12 cm distance range. In addition, polar dose profiles were calculated at distances ranging from 0.25 to 5 cm. The PDR and HDR dose-rate distributions are tabulated using the formalism endorsed by the Interstitial Collaborative Working Group and the AAPM Task Group 43, and includes dose-rate constant, radial dose function, anisotropy function, geometry function, and anisotropy factors. The dose-rate constants, lambda, of the MicroSelectron/HDR and PDR sources were found to be 1.115 and 1.128 cGy h-1 per unit air-kerma strength, respectively, in good agreement with previously published data for low dose-rate interstitial 192Ir sources. Oblique filtration by the high-density iridium metal core resulted in deviations from anisotropy as large as 35%-55% near the longitudinal axis of the source. Dose-rate distributions are also presented in Cartesian ("away" and "along") coordinates.

Brachytherapy↗
PubMed1995

Experimental validation of Monte Carlo dose calculations about a high-intensity Ir-192 source for pulsed dose-rate brachytherapy.

Despite widespread use of high-intensity Ir-192 remotely afterloaded sources, no published measured or calculated dose-rate tables for currently used source designs are available. For a pulsed dose-rate Ir-192 source, both transverse axis (0.5-10 cm) and two-dimensional polar dose-rate profiles (1.5, 3, and 5 cm) were measured with thermoluminescent dosimetry in a solid water phantom. Dose rates were normalized to measured air-kerma strength, and the source geometry was verified by pinhole autoradiography and transmission radiography. At each measurement point, dose rates were calculated by a Monte Carlo photon transport (MCPT) code, which realistically modeled the experimental phantom, source, and detector geometry. Agreement between MCPT absolute dose-rate calculations and measurements averaged 3% and was less than 5%, demonstrating that Monte Carlo simulation is an accurate and powerful tool for two-dimensional dosimetric characterization of high activity Ir-192 sources.

Brachytherapy↗
PubMed1994

A comparative study of dosimetric properties of Plastic Water and Solid Water in brachytherapy applications.

In this study the dosimetric properties of Plastic Water and Solid Water phantom materials are evaluated using Monte Carlo photon transport simulations. In particular, their water-equivalence with respect to absorption and attenuation of photons in the brachytherapy energy range are examined. For the given chemical compositions of the materials, the linear attenuation coefficients were calculated for photons of 1 keV-2 MeV. Moreover, absorbed doses to water in each phantom material were calculated at distances of 0.5-12.0 cm from point sources of 20 keV to 60Co gamma rays. These results show that at low photon energies (below 100 keV), there are substantial differences (up to a factor of 5) between the absorbed dose in Plastic Water and that in liquid water. The differences decrease as photon energy increases, and they become insignificant at 60Co gamma rays, as claimed by the manufacturer. In contrast, calculations show that the difference in absorbed dose in Solid Water from that in liquid water, over the entire range of photon energies employed in this study, is less than 25%. The results of this study demonstrate the necessity of careful dosimetric evaluation of a new phantom material, before its clinical application, particularly in energy ranges outside those referred to by the manufacturer.

Biophysical Phenomena↗
PubMed1992

Source configuration and dose rates for the Selectron afterloading equipment for gynecologic applicators.

This paper describes source train configurations of the Selectron LDR-6 that can be used to duplicate commonly used manually afterloadable source configurations for gynecological intracavitary brachytherapy. We demonstrate that the recommended source configuration using 2.5 mm 137Cs spheres is dosimetrically equivalent to its manually afterloaded counterparts using 3M 137Cs sources (20 mm overall length, 14 mm active length). Isodose distributions are in agreement to within 5% for the Fletcher-Suit-Delclos family of tandems, colpostats, and vaginal cylinders. Our data also demonstrate that the isotropic point source model used by most computerized treatment planning systems is a good approximation to source trains of filtered, spherical sources interspersed with solid steel spacers. We conclude that the use of 2.5 mm 137Cs sources in the Selectron remote afterloading system can accurately reproduce the isodose distribution achieved with linear 137Cs manually afterloaded sources.

Brachytherapy↗
PubMed1992

Dosimetry and dose specification for a new gynecological brachytherapy applicator.

A new afterloadable gynecological intracavitary applicator has been designed and is now in use for the treatment of a wide range of vaginal, cervical, and endometrial cancers in a single application, with a dose distribution that more closely matches the prescribed treatment than previous methods. The plexiglass applicator consists of a bulbous section that is inserted up to the vaginal apex and loaded with right and left ovoid sources. The distal portion is cylindrical with a central channel for tandem sources. A straight tandem is used when the target volume extends to the vaginal apex, but an intrauterine tandem can also be used. Extensive dosimetric and radiographic evaluations were performed to guide design refinements and to validate the surface dose predictions of the brachytherapy treatment planning system. The final applicator design delivers 110-120 cGy/hr to the vaginal apex surface and 95-100 cGy/hr to the distal vaginal surfaces when loaded with a 144.6 U (20 mgRaEq) cesium tube in each ovoid channel and 72.3, 72.3, and 144.6 U (10, 10, and 20 mgRaEq) cesium tubes in the vaginal cylinder channel. A system for treatment dose specification has been established that includes dose tables for manually calculating surface doses to reference points. A dose distribution comparison with a sequential colpostat-vaginal cylinder treatment demonstrates that dose delivery is more precise and uniform with this new applicator.

Brachytherapy↗
PubMed1992

Rapid two-dimensional dose measurement in brachytherapy using plastic scintillator sheet: linearity, signal-to-noise ratio, and energy response characteristics.

Because of the large dose gradients encountered near brachytherapy sources, an efficient, accurate, low-atomic number areal detector, which can record dose at many points simultaneously, is highly desirable. We have developed a prototype of such a system using thin plates of plastic scintillator as detectors. A micro-channel plate (MCP) image intensifier was used to amplify the optical scintillation images produced by radioactive 125I and 137Cs sources in water placed 0.5-5.7 cm distance from the detector. A charge-coupled device (CCD) digital camera was used to acquire 2-D light-intensity distributions from the image intensifier output window. For both isotopes, a small area (2 x 3 mm2) PVT detector yields a CCD net count rate that is linear with respect to absorbed dose rate within +/- 3% out to 5.7 cm distance. Acquisition times range from 1.5-400 sec with a reproducibility of 0.5-5.5%. If a large-area (6 x 20 cm2) PVT detector is used, a four-fold increase in count rate and large deviations from linearity are observed, indicating that neighboring pixels contribute light to the signal through diffusion and scattering in PVT and water. A detailed noise analysis demonstrates that the image intensifier reduces acquisition time 10000-fold, reduces noise relative to signal 200-fold, and reduces amplifier gain noise as well.

Brachytherapy↗
PubMed1990

Dose calculations about shielded gynecological colpostats.

Although shielded gynecological colpostats have been shown experimentally to reduce doses to bladder and rectal tissue by as much as 50%, nearly all previously described dose computation algorithms ignore applicator heterogeneities. We describe the use of realistic Monte Carlo calculations to study the dosimetric effects of applicator structure. Use of sophisticated solid modeling techniques allows the complex internal structure of two commercially-available Fletcher-Suit colpostats, as well as that of 226Ra or 137Cs tubes, to be accurately simulated. Our results show significant differences among these source-applicator combinations. In addition, a novel dose computation algorithm for efficiently estimating absorbed dose near shielded applicators is described. Our approach is based upon empirical separation of primary- and scatter-dose components. The algorithm requires a small base of Monte Carlo-generated data, reproduces the Monte Carlo dose estimates within 3%, and is faster than Monte Carlo by a factor of 15,000. The scatter-separation method has the potential to make accurate dose estimates to bladder, rectum, tumor, and vagina available for clinical treatment planning and for extraction of more meaningful dose-response curves from clinical data.

Brachytherapy↗
PubMed1988

Monte Carlo and analytic calculation of absorbed dose near 137Cs intracavitary sources.

This paper presents dose-rate tables and treatment planning data needed to accurately implement the Sievert line-source integral, found on most commercial computer-aided treatment planning systems, for two recently introduced 137Cs intracavitary sources. One source uses a high-density active core designed to reproduce the non-elliptical isodose curves characteristic of the traditional radium tube. The other source consists of two or three discrete 137Cs seeds encapsulated in stainless steel. Using Monte Carlo dose-rate calculations as the standard of accuracy, we show that the Sievert model, using conventionally defined filtration corrections, overestimates kerma-rate in free space by as much as 20%. In addition, tissue attenuation and scatter build-up factors, derived from an isotropic point source, do not accurately characterize the distribution of scatter dose about heavily filtered sources. By varying the input parameters of the Sievert line-source integral so as to optimize its agreement with the more rigorous Monte Carlo data, accuracy of 3% can be achieved.

Brachytherapy↗
PubMed1987

Random selection of points distributed on curved surfaces.

Monte Carlo simulation is widely used in medical physics to obtain realistic solutions to radiation transport problems involving complex geometries. An important step is the random selection of the initial point in space from which the primary photon or charged particle originates. In many practical cases, the primary-particle sites are distributed over curved surfaces. We describe general sampling techniques that can be used to randomly choose the trajectory origin for sources distributed over any smooth surface that can be parametrically represented as a function of two variables. The source distribution need not be uniform. Implementation of these methods is particularly straight-forward for surfaces enclosing simple convex volumes such as spheres and ellipsoids.

Humans↗
PubMed1987

Ionizing radiation enhances malignant progression of mouse skin tumors.

Chemical carcinogenesis in mouse skin has been divided into the process of initiation, promotion and progression. Recently we have shown that ionizing radiation acts as an initiator in this model system. In this paper we describe a three-stage experiment using ionizing radiation in the third stage of mouse skin carcinogenesis. CD-1 mice were initiated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) followed by biweekly promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). After 20 weeks of promotion, the animals were treated with either acetone, TPA (twice a week for 2 weeks) or eight fractions of 1 MeV electrons (1 Gy/fraction over a period of 10 days). The conversion of papillomas to squamous cell carcinomas was 80% for animals treated with ionizing radiation compared with 25% for tumor-bearing animals treated with TPA. Ionizing radiation increased the number of cumulative carcinomas per group. The lack of an increase in the number of cumulative papillomas per group due to ionizing radiation suggests that the dose and fractionation protocol used in this study enhanced the progression of pre-existing papillomas.

Acetone↗
PubMed1987

Template-guided interstitial implants: Cs-137 reusable sources as a substitute for Ir-192.

Template-guided implantation of rigid steel or plastic guide needles for afterloading of radioactive sources is widely used in the treatment of gynecologic, rectal, and urologic malignant neoplasms. Iridium-192 is used almost universally, despite the high cost per implant, due to its short half-life and limited need for a flexible, trimmable source. A reusable afterloading system containing cesium-137 was developed. Each source has an effective active length of 6.8 cm and is encapsulated at the distal end of a 21-cm-long stainless steel tube. The sources can be afterloaded into the same plastic guide needles normally used for Ir-192 ribbons. Physical and dosimetric aspects of these sources are compared with those of Ir-192, and radiation protection and cost effectiveness are also discussed.

Brachytherapy↗
PubMed1986

The accuracy of the line and point source approximations in Ir-192 dosimetry.

The dosimetric approximations used in computer-aided treatment planning of Ir-192 seed implants generally ignore individual seed dimensions and internal structure. Most commonly, each seed is approximated by an isotropic point source. Alternately, each ribbon assembly consisting of uniformly spaced seeds is replaced by an unfiltered line source. Using filtration corrections applicable to platinum- and steel-encapsulated seeds calculated by the Monte Carlo method, the dosimetric errors introduced by these models into two-and-three-dimensional dose distributions arising from multiple plane implants are analyzed. Our results demonstrate that when anisotropy correction factors of 0.96 and 0.99 are used for platinum- and steel-filtered seeds, respectively, the point source model is accurate within 2%. The accuracy of the line source approximation depends significantly upon the details of its implementation. If the linear density of the line is set equal to individual seed strength for an inter-seed spacing of 1 cm, and filtration correction factors of 0.94 and 0.97 are used for platinum- and steel-clad seeds, respectively, the accuracy of the line source model is 1.5% near the implant center. The method of dose-volume histograms is used to compare the predictions of the different models.

Brachytherapy↗
PubMed1984

Serial thyroid function measurements in children with Hodgkin disease.

Thyroid function was measured serially in 28 children with Hodgkin disease diagnosed from 1971 to 1978. The patients' ages ranged from 4 to 16 years at diagnosis, and treatment consisted of chemotherapy only (four patients), radiation alone (15), or radiation plus chemotherapy (nine). None of the four children given chemotherapy only developed thyroid hypofunction, in contrast to 21 (88%) of the 24 children given high doses of radiation (P less than 0.001). Thyroid function in three patients with compensated hypothyroidism and in one child with primary hypothyroidism reverted to normal without thyroid replacement. One child given chemotherapy only and one child given radiation only became transiently hyperthyroid. These results indicate that patients given combined modality therapy for Hodgkin disease are at high risk for thyroid abnormalities. The results of long-term follow-up of thyroid function demonstrate, however, that all such thyroid abnormalities may not necessarily be permanent.

Adolescent↗
PubMed1984

The significance of electron binding corrections in Monte Carlo photon transport calculations.

Many Monte Carlo simulations ignore coherent scattering events and utilise the Klein-Nishina free electron distribution, rather than the incoherent differential cross-section, for choosing the trajectories of incoherently scattered photons. We assess the accuracy of this model by comparing its results with those of the complete bound electron model (form factor approach), which simulates coherent scattering events, and uses the appropriate bound electron angular scattering distributions. Both analytic and Monte Carlo calculations demonstrate that use of the free electron scattering distributions significantly underestimates the angular distribution of scattered photon energy resulting from low and medium energy photons incident upon carbon, iron, and platinum barriers. In using the free electron approximations to calculate barrier transmission, significant errors occur only for primary photon energies below 100 keV. Implementation of the complete bound electron model reduces the computational efficiency of our Monte Carlo code by only 10-25%.

Electrons↗
PubMed1983

Ovarian function after successful bone marrow transplantation in postmenarcheal females.

Ovarian function was followed serially in a group of six postmenarcheal females after successful bone marrow transplantation (BMT). The patients were between 13 9/12 and 22 6/12 (median 16 5/12) years of age at the time of BMT and were followed a median of 20 months (range 17-45 months) posttransplantation. Two subjects received short-term high-dose cyclophosphamide combined with single-dose total lymphoid irradiation (Group I), whereas the remaining four were treated with short-term, high-dose chemotherapy plus single-dose total body irradiation (Group II). Group II subjects also received combination chemotherapy prior to BMT. One subject from Group I continues to have regular menses and normal gonadotropin levels, 36 months post-BMT. The remaining five patients have demonstrated persistently elevated plasma concentrations of LH and FSH over a 17- to 45-month period of time. None of the four patients in Group II has menstruated since undergoing BMT. We conclude that single-dose radiation combined with short-term, high-dose chemotherapy results in profound ovarian damage in the majority of young women undergoing BMT.

Adolescent↗
PubMed1983

Monte Carlo evaluation of the Sievert integral for brachytherapy dosimetry.

The Sievert integral, widely used to compute dose distributions about filtered line sources, assumes that the emitted energy fluence is exponentially attenuated by the filter thickness traversed by the primary photons. To evaluate this approximation, a Monte Carlo simulation was performed realistically modelling the diffusion and energy degradation of primary photons due to coherent, incoherent and photoelectric interactions in the source filter. Estimates of the exposure rate at points near the source were obtained using analytical averaging. Comparison of the two models shows that for 226Ra and 192Ir sources, the Sievert algorithm consistently overestimates the exposure rate per unit activity. However, such errors may be significantly reduced if source intensity is expressed in terms of exposure rate. Computed exposure rate distributions based on exposure rate calibrations are also less sensitive to uncertainties in available spectroscopic data.

Brachytherapy↗