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Biomedical subjects

J F White

Publications and source records attributed to J F White.

At least 109 records · Page 6Linked to original sources
PubMed1976

The influence of ethyl alcohol on cerebro-spinal fluid pressure.

The effect of ethanol on the cerebro-spinal fluid pressure of six baboons is described. A biphasic response is shown to the intravenous infusion with a mean pressure fall of 3.1 mmHg. It is suggested that both the diuretic effect and the effect of alcohol on cerebral blood flow may be factors involved in the pressure fall.

Animals↗
PubMed1976

Intracellular potassium activities in Amphiuma small intestine.

Intracellular potassium activity (aKi) has been determined in absorptive cells lining the villi of isolated, stripped proximal segments of Amphiuma small intestine. With single-barreled liquid ion-exchanger microelectrodes aKi = 41.6 +/- 1.5 mM in normal chloride buffer; with double-barreled microelectrodes constructed by a new method aKi = 38.5 +/- 2.4 mM. Also, by the latter approach aKi = 41.1 +/- 2.1 mM in buffer in which potassium was elevated to 5 meq/liter and aKi = 44.2 +/- 1.3 mM in sulfate buffer with the same bath potassium concentration. Since the calculated potassium equilibrium potential exceeds the membrane potential this ion is accumulated by the intestinal absorptive cell. A major portion of cellular potassium is bound or compartmentalized since the intracellular potassium activity coefficient is very low. A layer exists near the villi in which the potassium activity exceeds that in the bath buffer solution.

Amphibians↗
PubMedDate not supplied

Strategic planning for international nursing education.

International educational program planning is a complex process that benefits from the use of a strategic planning framework. The NANC project is presented as a demonstration model, utilizing the concepts and principles of strategic planning as outlined in the Regis Model. Developing and following a strategic plan in international nursing education is a necessity, rather than a luxury, in order to provide the necessary direction for your future providing a suggested "Blueprint for Action." Employing an effective strategic plan as your individualized "Blueprint for Action" can mean the difference between success and failure in your international "bridge-building efforts." The extensive assessment, planning, and review process identified through the utilization of the Regis Model that preceded the implementation of the NANC project was the key factor to project success. It is hoped that utilization of a strategic planning model such as the Regis Model, used in this project, will provide a general "Blueprint for Success" for those who are committed to quality international nursing education.

Education, Nursing↗
PubMedDate not supplied

Epinephrine-induced cardiac arrhythmias in rabbits exposed to trichloroethylene: potentiation by caffeine.

Approximately 200 000 industrial workers are exposed to trichloroethylene in the United States. Individuals intoxicated with trichloroethylene are known to develop cardiac arrhythmias. Caffeine is known to be a cardiac stimulant and is one of the drugs most widely used by the American population. Therefore, it was of interest to study the effect of caffeine on the arrhythmogenicity of trichloroethylene. Rabbits were treated with a vehicle control (1 mL/kg, ip) or caffeine (10 mg/kg, ip, 30 minutes prior to exposure) and exposed for one hour to 6000 ppm trichlorethylene under dynamic airflow conditions. Epinephrine was infused until arrhythmias occurred after 7.5, 15, 30, 45 and 60 minutes of exposure and also 15 and 30 minutes post-exposure. Serial blood samples were collected at these time points and analyzed for trichloroethylene and the two major metabolites, trichloroethanol and trichloroacetic acid. Rabbits treated with caffeine and exposed to trichloroethylene developed more arrhythmias in response to epinephrine than rabbits exposed to trichloroethylene alone, and the arrhythmias occurred sooner and in response to lower doses of epinephrine. Caffeine treatment had no effect on trichloroethylene blood concentration, but significantly decreased trichloroethanol blood levels after 45 and 60 minutes of exposure to trichloroethylene. Caffeine also reduced blood levels of trichloroacetic acid. The data indicate that caffeine can potentiate the arrhythmogenicity of trichloroethylene in rabbits.

Animals↗
PubMedDate not supplied

Cardiac arrest temperature: the effect of ethyl alcohol and carbon dioxide on rats, guinea-pigs and isolated rat hearts.

1. Previous clinical and experimental reports have suggested that the systemic administration of ethyl alcohol permits lower body temperatures before the onset of hypothermic cardiac arrest. 2. In the investigations described here, the effect of ethyl alcohol on the temperature at which cardiac arrest occurred in rats, guinea-pigs and isolated rat hearts was studied. Comparison was also made of the difference between pulmonary ventilation with air and with 5% carbon dioxide in oxygen. 3. The results demonstrated that both the administration of ethyl alcohol and ventilation with 5% carbogen reduced the cardiac arrest temperature of rats. Ethyl alcohol did not influence the cardiac arrest temperature of guinea-pigs nor of isolated rat hearts.

Animals↗
PubMedDate not supplied

A study of the thermogenic effect of ethanol in the hypothermic rat.

1. The hypothesis that ethanol may exert a thermogenic effect in cold environments was studied by infusing ethanol, dextrose or saline into hypothermic rats and observing the rate of rewarming in each group. 2. No difference was found in the rate of heat gain in any of the three groups.

Animals↗