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Biomedical subjects

J F Stara

Publications and source records attributed to J F Stara.

At least 37 records · Page 2Linked to original sources
PubMed1975

Dermal irritancy of metal compounds. Studies with palladium, platinum, lead, and manganese compounds.

Dermal irritancy of 14 materials, including several compounds of palladium, platinum and lead, and methylcyclopentadienyl manganese tricarbonyl, plus deionized water (negative control) and glacial acetic acid (positive control), was tested on male albino rabbits weighing 2 to 3 kg. Procedures and evaluation criteria were adopted from those in use by the National Institute for Occupational Safety and Health. Five materials were evaluated as unsafe for intact or abraded skin contact as judged by severity of responses: glacial acetic acid (C3H5PDCl)2, (NH4)2PdCl4, (NH4)2PdCl6, and PtCl4; one as safe for intact, but not for abraded, skin: K2PdCl6; and two as safe for intact skin but not for abraded skin unless protected: K2PdCl4 and PdCl2. The remainder were evaluated as safe for intact or abraded skin contact (irritancy grade less than 1 on a scale of 4): H2O, Pd(NH3)2Cl2, PdO, PtO2, PtCl2, PbCl2, PbO, MMT.

Acetates↗
PubMed1975

Inhalation toxicology of automotive emissions as affected by an oxidation exhaust catalyst.

Preliminary data are given on the acute inhalation toxicology of automotive emissions as affected by an oxidation exhaust catalyst. The catalyst effectively reduced CO and HC in the exhause which apparently had an effect (at least in a closed exposure system) on oxidant and NO2 levels by altering the HC/NOx ratio. There was a resultant reduction in biological effects due to the exposure. The catalyst altered the type of particulate to one which probably contained sulfuric acid as a major component. No evidence was present in these acute exposures to suggest a toxic response due to the higher sulfate emissions or possible catalyst attrition products. The effects of long-term exposure have not yet been investigated.

Air Pollution↗
PubMed1975

Whole body retention in rats of different 191Pt compounds following inhalation exposure.

The whole body retention, excretion, lung clearance, distribution, and concentration of 191Pt in other tissues was determined in rats following a single inhalation exposure to different chemical forms of 191Pt. The chemical forms of 191Pt used in study were 191PtCl4, 191Pt(SO4)2, 191PtO, and 191Pt metal. Immediately after exposure most of the 191Pt was found in the gastrointestinal and respiratory tract. Movement of the 191Pt through the gastrointestinal tract was rapid, most of the 191Pt being eliminated within 24 hr after exposure. Lung clearance was much slower, with a clearance half-time of about 8 days. In addition to the lungs, kidney and bone contained the highest concentrations of 191Pt.

Aerosols↗
PubMed1973

Cytologic changes in dogs lungs induced by chronic exposure to ozone.

Beagle dogs exposed for 8 hours a day to 3 ppm O(3) for 18 months showed cytologic changes that indicate metabolic alterations. The endoplasmic reticulum of the type 2 alveolar epithelial cells in the proximal alveoli were frequently dilated and contained a moderately electron-dense substance having a periodicity of approximately 754 A. This condition was accompanied by a substantial reduction in the lamellar membranes in the characteristic lamellar bodies of the type 2 cells, suggesting a sequestering of protein in the endoplasmic reticulum. In addition, endothelial cells contained paracrystalline arrays of cytoplasmic membranes not observed in control animals.

Animals↗