Suppressor-cell function and autoimmunity.
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Animals↗
Biomedical subjects
J F Scavulli
Publications and source records attributed to J F Scavulli.
Independent analysis of T helper and T killer cell function in young and old NZB mice.
With age, NZB mice lose their ability to develop a cytotoxic response after alloimmunization in vitro. This decline is shown to coincide with a diminution of T-helper cell activity as assessed by proliferation in mixed lymphocyte culture or in response to PHA. When cytotoxic T cell precursors are activated with the polyclonal activator Con A, there is no reduction in the number of cytotoxic effector T cells that develop. No autoreactive cytotoxic cells are seen in Con A-activated cultures. These findings are related to previous work on cell-mediated immunity in NZB and B/W mice.
Aging↗
Intra-articular calcification in scleroderma.
Two patients with scleroderma demonstrated intra-articular calcification, which is rarely observed in this disease. The authors suggest that intra-articular calcification and erosion of adjacent cartilage and bone are related.
Adult↗