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J F Roche

Publications and source records attributed to J F Roche.

154 records · Page 9Linked to original sources
PubMedDate not supplied

[Familial hypobetalipoproteinemia. Familial study of 4 cases].

A familial study of four cases with hypobetalipoproteinemia is reported. Three members are heterozygous and one is homozygous. This congenital fat malabsorption in homozygous state is commonly associated with an absence of serum apoprotein B and LDL. Neuromuscular and ophthalmological signs are absent in this case. The major role of upper digestive endoscopy in the diagnostic procedure is emphasized. Histochemical and immunoenzymatic stains of enterocytes and intestinal organ culture show defective synthesis apo B in the homozygous patient. Studies of DNA polymorphism in the homozygous patient have shown that the apo B gene doesn't certain major insertions or deletions. These results are discussed.

Adult↗
PubMedDate not supplied

[Amiodarone-induced hepatitis: biological, histological diagnosis, development and role of associated factors. Review of the literature. Report of 2 cases].

Two cases of pseudo-alcoholic amiodarone-induced hepatitis are reported. The authors mention the different clinical forms of the disease and describe its clinical, biochemical and histological features. They stress the unpredictable and discordant character of its course and the influence of associated pathological factors. The role played by Ito's cells in the genesis of the liver fibrosis observed in amiodarone toxicity is discussed.

Amiodarone↗