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Biomedical subjects

J F Riley

Publications and source records attributed to J F Riley.

11 recordsLinked to original sources
PubMed1988

Chronic pain and functional impairment: assessing beliefs about their relationship.

Many chronic pain patients believe that they cannot function normally because of their pain. The Pain and Impairment Relationship Scale (PAIRS) was developed to assess the extent to which chronic pain patients endorse this belief, and the relationship of this belief to functional impairment, measured both subjectively and objectively. The PAIRS was administered to 56 patients in a chronic pain treatment program. The PAIRS demonstrated adequate internal consistency and it correlated significantly with another measure of the cognitive component of chronic pain syndrome, the Cognitive Errors Questionnaire--Low Back Scale. The PAIRS accounted for a significant proportion of variance in several measures of impairment (including the Sickness Impact Profile, restrictions in range of motion, and statements of limitation during a standardized exercise routine) beyond that accounted for solely by subjective pain estimate in multiple regression analyses. It appears that the belief that pain necessarily implies disability is associated with actual impairment, independent of the actual contribution of reported pain.

Adult↗
PubMed1977

The mast cell/heparin paradox.

Purified heparin extracted from tissues rich in mast cells remains the ideal rapid anticoagulant in clinical practice. Nevertheless, there are grounds for doubting that an injection of commercial heparin corresponds to the release of heparin-containing granules from the mast cells. The metachromatic granule contains much more than heparin--chondroitins, heparitins, histamine (in some species 5-hydroxytryptamine also), and a variety of enzymes. Shed granules, released by trauma of any kind, are ingested by connective-tissue phagocytes and are digested. Commercial heparin, on the other hand, is taken up by cells of the reticuloendothelial system and is stored there. This apparent paradox can be resolved by conceding that the mast cell is primarily concerned with the connective tissue, as Ehrlich saw it a century ago, and that, within these broad limits, it can express itself in a variety of ways.

Animals↗
PubMed1976

Mast-cell reaction in precancerous mouse skin: an immunological response?

The promotion phase of carcinogenesis in mouse skin is accompanied by a mast-cell reaction in the upper dermis. Evidence is presented which suggests that this may be an immunological response, whereby distant lymphocytes migrate to the area and, in the presence of young fibroblasts, become transformed into tissue mast cells.

Animals↗
PubMed1976

Mast cells in the skin of normal, hairless and athymic mice.

The skin of congenitally athymic nu/nu mice is rich in mast cells which stain metachromatically, contain histamine and 5-hydroxytryptamine, and participate in the PCA reaction. Mast cells of athymic mice have thus the attributes of normal mast cells.

9,10-Dimethyl-1,2-benzanthracene↗